Cholestane-3,6-diol, 5-chloro-, diacetate, (3b,5a,6b)- | 1896-91-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Cholestane-3,6-diol, 5-chloro-, diacetate, (3b,5a,6b)-
• 英文别名: 5-chloro-5α-cholestane-3β,6β.diol diacetate；3β,6β-diacetoxy-5α-chlorocholestane；5-chloro-3β.6β-diacetoxy-5α-cholestane；(10R)-5t-Chlor-3c.6c-diacetoxy-10r.13c-dimethyl-17c-((R)-1.5-dimethyl-hexyl)-(8cH.9tH.14tH)-hexadecahydro-1H-cyclopenta[a]phenanthren；5-Chlor-3β.6β-diacetoxy-5α-cholestan；5α-Chlor-3β,6β-diacetoxy-cholestan
• CAS: 1896-91-9
• 化学式: C₃₁H₅₁ClO₄
• 分子量: 523.197
• InChiKey: MCXVQWPANZEPMI-ZJBXHLDWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.94
• 重原子数：
  36.0
• 可旋转键数：
  7.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  52.6
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  Cholestane-3,6-diol, 5-chloro-, diacetate, (3b,5a,6b)- 生成 Cholest-4-en-3β,6β-diol
  参考文献：
  名称：

  Lindgren,B.O.; Svahn,C.M., Acta Chemica Scandinavica (1947), 1970, vol. 24, p. 2699 - 2704

  摘要：

  DOI：
• 作为产物：
  描述：

  5β,6β-环氧胆甾烷-3β-OL 在 盐酸 作用下， 生成 Cholestane-3,6-diol, 5-chloro-, diacetate, (3b,5a,6b)-
  参考文献：
  名称：

  164. β -胆固醇氧化

  摘要：

  DOI：

  10.1039/jr9430000613

文献信息

• Reductions of steroidal halohydrins and their esters by tri-n.butyltin hydride; some stereospecific 1.2-migrations of acetoxy- or benzoxy-groups
  作者：Sylvestre A. Julia、Robert Lorne

  DOI：10.1016/s0040-4020(01)88052-2

  日期：1986.1

  bearing hydroxy-, acetoxy- or benzoxy-groups in the 3β and 4β or 3β and 6β positions, , , , , , and have been hydrogenolysed with the title reagent to afford the corresponding reduced derivatives. The reduction of 4α-chloro-5β-cholestane-3β, 5-diol 3-benzoate () and 3α-chloro-5α-cholestan-2β-ol acetate gave also the products of simple hydrogenolysis.

  六5α氯和一种5α溴胆甾烷衍生物轴承羟基，乙酰氧基或苯甲酰氧基的基团在3β和4β或3β和6β位置，，，，，和已被氢解，与标题试剂，得到相应的还原导数。4α-氯-5β-胆甾烷-3β，5-二醇3-苯甲酸酯（）和3α-氯-5α-胆甾烷-2β-醇乙酸酯的还原也产生了简单的氢解产物。
• Husain, Mubarak; Khan, Naseem Hasan, Synthetic Communications, 1981, vol. 11, # 3, p. 185 - 208
  作者：Husain, Mubarak、Khan, Naseem Hasan

  DOI：——

  日期：——
• Long-Term Monitoring and Analysis of Hourly Solar UV Radiation in the 290-380 <i>nm</i> Range in the Middle Region of Saudi Arabia
  作者：A.M. Al-Dhafiri、M.S. Al-Ayed、M. Bin Mahfoodh

  DOI：10.1080/10473289.2000.10464148

  日期：2000.6

  The UV and global solar radiation on a horizontal surface at ground level in Riyadh City (latitude 24 degrees 34' N, longitude 46 degrees 43' E) have been measured and analyzed. Measurements of UV radiation (295-385 nm) were recorded every 10 min for five years (January 1983-December 1987). The maximum recorded hourly mean irradiance UV radiation was 28 W/m(2) and occurred in July, while the minimum was 14 W/m(2) in December. A steady monthly value of K-vh = (UV/H) was obtained and equaled 2.9%. A similar trend was found for the monthly variation of K-t = (H/H-o) and K-v = (UV/H-o) Maximum values of 90% and 2.6% were recorded in June for K-t and K-v, respectively, while minimum values of 35% and 1%, respectively, were obtained in December. A linear correlation was obtained between K-v and K-t. These findings were discussed and connected to the meteorological events. The results were compared with the regions of Kuwait, Bahrain, Dhahran, and Makkah.
• Hattori, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1940, vol. 60, p. 334,338; engl. Ref. S. 125
  作者：Hattori

  DOI：——

  日期：——
• Kocor,M. et al., Bulletin de l'Academie Polonaise des Sciences, Serie des Sciences Chimiques, 1966, vol. 14, p. 79 - 84
  作者：Kocor,M. et al.

  DOI：——

  日期：——