1-amino-2-phenyl-pentan-2-ol | 100054-37-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-amino-2-phenyl-pentan-2-ol
• 英文别名: 1-amino-2-phenyl-2-pentanol；1-amino-2-phenylpentan-2-ol
• CAS: 100054-37-3
• 化学式: C₁₁H₁₇NO
• 分子量: 179.262
• InChiKey: CUQIXSHMVVABAI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-amino-2-phenyl-pentan-2-ol 生成 N-(2-hydroxy-2-phenyl-pentyl)-benzamide
  参考文献：
  名称：

  THE ACTION OF GRIGNARD REAGENTS ON OXIMES. IV. ALIPHATIC GRIGNARD REAGENTS AND MIXED KETOXIMES¹

  摘要：

  DOI：

  10.1021/jo01184a008
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 硫酸 作用下， 生成 1-amino-2-phenyl-pentan-2-ol
  参考文献：
  名称：

  THE ACTION OF GRIGNARD REAGENTS ON OXIMES. IV. ALIPHATIC GRIGNARD REAGENTS AND MIXED KETOXIMES¹

  摘要：

  DOI：

  10.1021/jo01184a008

文献信息

• THIAZOLYL COMPOUNDS USEFUL AS KINASE INHIBITORS
  申请人：Marinier Anne

  公开号：US20100048581A1

  公开（公告）日：2010-02-25

  The invention provides compounds of formula I [INSERT CHEMICAL STRUCTURE HERE] (I) and pharmaceutically acceptable salts thereof. The formula I thiazolyl compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents and for the treatment of Alzheimer's Disease.

  这项发明提供了化合物I的公式[插入化学结构在这里]（I）及其药学上可接受的盐。公式I的噻唑基化合物抑制酪氨酸激酶活性，因此可用作抗癌剂以及治疗阿尔茨海默病。
• 4-substituted quinoline derivatives
  申请人：Neurogen Corporation

  公开号：US20020198232A1

  公开（公告）日：2002-12-26

  Disclosed are compounds of Formula 1 where R 1 , R 2 , R 3 , R 4 , X, Y 1 , and Y 2 are defined herein. These compounds bind with high affinity to NK-3 receptors and/or GABA A receptors. Also provided are pharmaceutical compositions comprising these compounds, and methods of treating patients suffering from various central nervous system and peripheral diseases or disorders with these pharmaceutical compositions. This invention also relates to the use of such compounds in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. The compounds of this invention are also useful as probes for the localization of NK-3 receptors and GABA A receptors.

  本发明涉及公式1化合物，其中R1、R2、R3、R4、X、Y1和Y2的定义如下。这些化合物与NK-3受体和/或GABAA受体具有高亲和力。还提供了包含这些化合物的药物组合物以及使用这些药物组合物治疗患有各种中枢神经系统和外周疾病或障碍的患者的方法。本发明还涉及将这种化合物与一个或多个其他中枢神经系统药物组合使用以增强其他中枢神经系统药物的效果。本发明的化合物还可用作定位NK-3受体和GABAA受体的探针。
• 4-Substituted quinoline derivatives
  申请人：Neurogen Corporation

  公开号：US06624175B2

  公开（公告）日：2003-09-23

  Disclosed are compounds of the Formula where R1, R2, R3, R4, X, Y1, and Y2 are defined herein. These compounds bind with high affinity to NK-3 receptors and/or GABAA receptors. Also provided are pharmaceutical compositions comprising these compounds, and methods of treating patients suffering from various central nervous system and peripheral diseases or disorders with these pharmaceutical compositions. This invention also relates to the use of such compounds in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. The compounds of this invention are also useful as probes for the localization of NK-3 receptors and GABAA receptors.

  本发明涉及的化合物具有下列式中所定义的R1、R2、R3、R4、X、Y1和Y2。这些化合物与NK-3受体和/或GABAA受体结合亲和力高。本发明还提供了包含这些化合物的制药组合物以及使用这些制药组合物治疗患有各种中枢神经系统和周围疾病或疾病的患者的方法。本发明还涉及使用这种化合物与一个或多个其他中枢神经系统药物结合以增强其他中枢神经系统药物的效果。本发明所述的化合物还可用作定位NK-3受体和GABAA受体的探针。
• Thiazolyl compounds useful as kinase inhibitors
  申请人：Bristol-Myers Squibb Company

  公开号：US08148400B2

  公开（公告）日：2012-04-03

  The invention provides compounds of formula II: and pharmaceutically acceptable salts thereof. The formula II thiazolyl compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents and for the treatment of Alzheimer's Disease.

  该发明提供了II式化合物及其药学上可接受的盐。II式噻唑基化合物抑制酪氨酸激酶活性，因此可用作抗癌剂和治疗阿尔茨海默病的药物。
• 4-SUBSTITUTED QUINOLINE DERIVATIVES AS NK-3 AND/OR GABA(A) RECEPTOR LIGANDS
  申请人：NEUROGEN CORPORATION

  公开号：EP1165542A1

  公开（公告）日：2002-01-02