diethyl 9,10,11,11a-tetrahydro-8H-pyrido[2,1-a][2,7]naphthyridine-5,6-dicarboxylate | 811442-58-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: diethyl 9,10,11,11a-tetrahydro-8H-pyrido[2,1-a][2,7]naphthyridine-5,6-dicarboxylate
• CAS: 811442-58-7
• 化学式: C₁₈H₂₂N₂O₄
• 分子量: 330.384
• InChiKey: YSZZHLQXMJYPEN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  68.7
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  diethyl 9,10,11,11a-tetrahydro-8H-pyrido[2,1-a][2,7]naphthyridine-5,6-dicarboxylate 以12%的产率得到ethyl 9,10,11,11a-tetrahydro-8H-pyrido[2,1-a][2,7]naphthyridine-5-carboxylate
  参考文献：
  名称：

  Microwave-mediated reactions of 3-aminomethylpyridines with acetylenedicarboxylates. A novel synthetic route to dihydronaphthyridines and naphthyridine-1-ones

  摘要：

  Reaction of 3-(1-alkylamino)pyridines with electron deficient acetylenes in the presence of acids yields 1,2-dihydro-[2,7]naphthyridine-3,4-dialkyldicarboxylates 4 in 35-72% yield. Compounds 4 unsubstituted in position 1 can be easily oxidized with potassium permanganate into the respective naphthyridine-1-ones derivatives 5 in good yields. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.04.053
• 作为产物：
  描述：

  +-八角枫碱 在 三氟乙酸 作用下， 以 乙醇 为溶剂， 反应 12.83h， 生成 diethyl 9,10,11,11a-tetrahydro-8H-pyrido[2,1-a][2,7]naphthyridine-5,6-dicarboxylate
  参考文献：
  名称：

  Microwave-mediated reactions of 3-aminomethylpyridines with acetylenedicarboxylates. A novel synthetic route to dihydronaphthyridines and naphthyridine-1-ones

  摘要：

  Reaction of 3-(1-alkylamino)pyridines with electron deficient acetylenes in the presence of acids yields 1,2-dihydro-[2,7]naphthyridine-3,4-dialkyldicarboxylates 4 in 35-72% yield. Compounds 4 unsubstituted in position 1 can be easily oxidized with potassium permanganate into the respective naphthyridine-1-ones derivatives 5 in good yields. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.04.053

文献信息

• Microwave-mediated reactions of 3-aminomethylpyridines with acetylenedicarboxylates. A novel synthetic route to dihydronaphthyridines and naphthyridine-1-ones
  作者：Vladimir Y. Vvedensky、Yury V. Ivanov、Volodymyr Kysil、Caroline Williams、Sergei Tkachenko、Alexander Kiselyov、Alexander V. Khvat、Alexandre V. Ivachtchenko

  DOI：10.1016/j.tetlet.2005.04.053

  日期：2005.6

  Reaction of 3-(1-alkylamino)pyridines with electron deficient acetylenes in the presence of acids yields 1,2-dihydro-[2,7]naphthyridine-3,4-dialkyldicarboxylates 4 in 35-72% yield. Compounds 4 unsubstituted in position 1 can be easily oxidized with potassium permanganate into the respective naphthyridine-1-ones derivatives 5 in good yields. (c) 2005 Elsevier Ltd. All rights reserved.