3-alpha-methoxyandrost-4-ene-6,17-dione | 133233-43-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3-alpha-methoxyandrost-4-ene-6,17-dione
• 英文别名: (3R,8R,9S,10R,13S,14S)-3-methoxy-10,13-dimethyl-2,3,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-6,17-dione
• CAS: 133233-43-9
• 化学式: C₂₀H₂₈O₃
• 分子量: 316.441
• InChiKey: YMUKHCWRZBKVLF-WAPOVMQPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-羟基雄甾-4-烯-6,17-二酮 在 吡啶 作用下， 反应 20.83h， 生成 3-alpha-methoxyandrost-4-ene-6,17-dione
  参考文献：
  名称：

  竞争抑制和雄激素-4-烯-3,6-二酮衍生物和3α-甲氧基雄酮-4-烯-6,17-二酮对人胎盘芳香酶的杀灭作用。

  摘要：

  制备了Androst-4-ene-3,6-dione衍生物2-4和3α-甲氧基-4-en-6-一个甾体7，并测试了它们抑制人胎盘微粒体中芳香化酶的能力。该系列的16α-溴化物2、16α-醇3和3α-甲醇盐7是有效的芳香化酶竞争性抑制剂，表观Ki分别为150 nM，1.18 microM和700 nM。在烟酰胺腺嘌呤二核苷酸磷酸（NADPH）还原的情况下，化合物2导致时间依赖性芳香酶活性双相丧失，而化合物7导致活性的时间依赖性伪一阶失活，其激酶活性为0.417和0.036分钟对于化合物2和7-1。NADPH和氧气是时间依赖性灭活所必需的，在每种情况下，基质，rost-4-ene-3,17-dione都可以防止这种情况。

  DOI：

  10.1248/cpb.38.3076

文献信息

• Methods and compositions for the treatment of estrogen-dependent hyperproliferative uterine disorders
  申请人：Wang Changjin

  公开号：US20100087402A1

  公开（公告）日：2010-04-08

  The present invention relates to the treatment of estrogen-dependent hyperproliferative uterine disorders including endometriosis, uterine fibroids, endometrial hyperplasia, uterine cancer, and their related symptoms by intravaginally administering at least two active agents selected from an aromatase inhibitor, an antiinflammatory agent, and a uterine-selective estrogen receptor antagonist. This combination therapy reduces local estrogen production, blocks local estrogen action, and suppresses inflammation locally, resulting in starvation of the estrogen-dependent diseased tissues, relief of related symptoms, and retardation of disease progression. Intravaginal delivery maximizes local inhibition of estrogen production without significantly affecting systemic circulating estrogen levels. This results in enhanced clinical efficacy and reduced side effects.

  本发明涉及治疗依赖雌激素的子宫过度增生性疾病，包括子宫内膜异位症、子宫肌瘤、子宫内膜增生、子宫癌及其相关症状，通过阴道给药至少两种活性药物，所选药物包括芳香化酶抑制剂、抗炎药和子宫选择性雌激素受体拮抗剂。这种联合疗法降低了局部雌激素产生，阻断了局部雌激素作用，并在局部抑制了炎症，导致对依赖雌激素的疾病组织的饥饿，缓解相关症状，延缓疾病进展。阴道给药最大限度地抑制了局部雌激素产生，而不显著影响全身循环雌激素水平。这导致增强的临床疗效和减少的副作用。
• composition and uses for influencing hair growth
  申请人：Schmidt Alfred

  公开号：US20110117218A1

  公开（公告）日：2011-05-19

  The invention describes a combination of at least one aromatase inhibitor selected from the group of chemical-synthetic aromatase inhibitors and aromatase inhibition exhibiting extracts of soya beans and rapeseed, respectively, and at least one plant extract that contains one or more active ingredient substance(s) extracted from the plant, which is(are) selected from the group of 5α reductase type I and/or type II inhibitors and androgen receptor blockers, said combination being contained for example in a composition and having special properties for influencing hair growth. Uses of this combination are also described.

  该发明描述了一种组合物，该组合物包括至少一种从化学合成芳香化酶抑制剂和大豆和油菜籽提取物中选择的芳香化酶抑制剂和至少一种植物提取物，该植物提取物含有从植物中提取的一个或多个活性成分，所述活性成分从5α还原酶I型和/或II型抑制剂和雄激素受体阻断剂中选择，该组合物例如包含在一种组合物中，并具有影响头发生长的特殊性质。还描述了该组合物的用途。
• Composition and uses for influencing hair growth
  申请人：S.W. Patentverwertungs Limited

  公开号：US11052059B2

  公开（公告）日：2021-07-06

  The invention describes a combination of at least one aromatase inhibitor selected from the group of chemical-synthetic aromatase inhibitors and aromatase inhibition exhibiting extracts of soya beans and rapeseed, respectively, and at least one plant extract that contains one or more active ingredient substance(s) extracted from the plant, which is(are) selected from the group of 5α reductase type I and/or type II inhibitors and androgen receptor blockers, said combination being contained for example in a composition and having special properties for influencing hair growth. Uses of this combination are also described.

  本发明描述了至少一种芳香化酶抑制剂（分别选自化学合成芳香化酶抑制剂和具有芳香化酶抑制作用的大豆和油菜籽萃取物）与至少一种植物萃取物的组合，该植物萃取物含有一种或多种从植物中提取的活性成分物质，这些活性成分物质选自 5α 还原酶 I 型和/或 II 型抑制剂以及雄激素受体阻断剂。此外，还介绍了这种组合物的用途。
• ZUSAMMENSETZUNG UND VERWENDUNGEN ZUR BEEINFLUSSUNG DES HAARWACHSTUMS
  申请人：S.w. Patentverwertungs Limited

  公开号：EP2262471A2

  公开（公告）日：2010-12-22
• Substances and agents for positively influencing collagen
  申请人：Wieland Heinrich

  公开号：US20070148123A1

  公开（公告）日：2007-06-28

  The invention relates to the use of a substance and/or substances or a composition containing said substance and/or substances, whereby said substance and/or substances inhibit(s) the formation and/or the effect of estrogen to stabilize, increase and/or restore collagen. The appropriate substances are aromatase inhibitors and/or anti-estrogens. Optionally, 5-alpha-reductase inhibitors are also used.