9-Bromonon-1-en-7-yn-4-yloxy-tert-butyl-dimethylsilane | 912459-46-2

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: 9-Bromonon-1-en-7-yn-4-yloxy-tert-butyl-dimethylsilane
• 英文别名: 9-bromonon-1-en-7-yn-4-yloxy-tert-butyl-dimethylsilane
• CAS: 912459-46-2
• 化学式: C₁₅H₂₇BrOSi
• 分子量: 331.368
• InChiKey: XDEQRRRWTJDMMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.13
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  9-Bromonon-1-en-7-yn-4-yloxy-tert-butyl-dimethylsilane 在 双(三甲基硅烷基)氨基钾 作用下， 以 四氢呋喃 、 乙醚 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 4.0h， 生成
  参考文献：
  名称：

  Dienyne RCM/Diels–Alder approach for the construction of novel steroid-like polycyclic systems

  摘要：

  Our studies directed towards the preparation of novel steroid-like derivatives using RCM reactions are described. The strategy here described was applied to the construction of novel ring-inserted skeleton-expanded steroid analogs by combination of tandem ring-closing metathesis of lineal dienynes and Diels-Alder reaction. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.07.040
• 作为产物：
  描述：

  6-[Tert-butyl(dimethyl)silyl]oxynon-8-en-2-yn-1-ol 在 四溴化碳 、 三苯基膦 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以67%的产率得到9-Bromonon-1-en-7-yn-4-yloxy-tert-butyl-dimethylsilane
  参考文献：
  名称：

  Dienyne RCM/Diels–Alder approach for the construction of novel steroid-like polycyclic systems

  摘要：

  Our studies directed towards the preparation of novel steroid-like derivatives using RCM reactions are described. The strategy here described was applied to the construction of novel ring-inserted skeleton-expanded steroid analogs by combination of tandem ring-closing metathesis of lineal dienynes and Diels-Alder reaction. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.07.040

文献信息

• Dienyne RCM/Diels–Alder approach for the construction of novel steroid-like polycyclic systems
  作者：María José Aldegunde、Eva M. Codesido、Luis Castedo、Juan R. Granja

  DOI：10.1016/j.tetlet.2006.07.040

  日期：2006.9

  Our studies directed towards the preparation of novel steroid-like derivatives using RCM reactions are described. The strategy here described was applied to the construction of novel ring-inserted skeleton-expanded steroid analogs by combination of tandem ring-closing metathesis of lineal dienynes and Diels-Alder reaction. (c) 2006 Elsevier Ltd. All rights reserved.