estradiol-17β caprylate | 63042-22-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: estradiol-17β caprylate
• 英文别名: 17β-octanoyloxy-estratrien-(1.3.5(10))-ol-(3)；(8R)-3-Hydroxy-17c-octanoyloxy-13c-methyl-(8rH.9tH.14tH)-7.8.9.11.12.13.14.15.16.17-decahydro-6H-cyclopenta[a]phenanthren；Octansaeure-[3-hydroxy-oestratrien-(1.3.5(10))-yl-(17β)-ester]；17β-Octanoyloxy-oestratrien-(1.3.5(10))-ol-(3)；17β-Octanoyloxy-oestratrien-(A)-ol-(3)；Estra-1,3,5(10)-triene-3,17beta-diol 17-octanoate；[(8R,9S,13S,14S,17S)-3-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] octanoate
• CAS: 63042-22-8
• 化学式: C₂₆H₃₈O₃
• 分子量: 398.586
• InChiKey: VJJJFYBJSXJBPB-XRKIENNPSA-N

物化性质

• 沸点：
  461.73°C (rough estimate)
• 密度：
  1.0693 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  7.6
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3.17β-dioctanoyloxy-estratriene-(1.3.5(10)) 在 甲醇 、 potassium carbonate 作用下， 生成 estradiol-17β caprylate
  参考文献：
  名称：

  Miescher; Scholz; Tschopp, Biochemical Journal, 1938, vol. 32, p. 1273,1274

  摘要：

  DOI：

文献信息

• Activation of novel estrogen receptor supports and neuronal viability and function
  申请人：——

  公开号：US20010016325A1

  公开（公告）日：2001-08-23

  Neurological dysfunction is prevented or treated by the administration of ligands that activate the GPR30 receptor. Ligands include, but are not limited to, estrogens and structurally related molecules. In a preferred embodiment, the GPR30 ligand is an orally available drug that can cross into the brain from blood. Of particular interest are ligands that do not activate other estrogen receptors, and therefore do not have the classical estrogenic effects attributable to these receptors.

  通过施用激活 GPR30 受体的配体，可以预防或治疗神经功能紊乱。配体包括但不限于雌激素和结构相关的分子。在一个优选的实施方案中，GPR30 配体是一种可从血液进入大脑的口服药物。特别值得关注的是，配体不能激活其他雌激素受体，因此不具有这些受体的经典雌激素效应。
• CH211258
  申请人：——

  公开号：——

  公开（公告）日：——
• HERPES VIRUS-BASED COMPOSITIONS AND METHODS OF USE IN THE PRENATAL AND PERINATAL PERIODS
  申请人：THE UNIVERSITY OF ROCHESTER

  公开号：EP1903873A2

  公开（公告）日：2008-04-02
• Methods to accelerate the isolation of novel cell strains from pluripotent stem cells and cells obtained thereby
  申请人：West D. Michael

  公开号：US20080070303A1

  公开（公告）日：2008-03-20

  This invention generally relates to methods to differentiate pluripotent stem cells, such as embryonic stem, embryonic germ, or embryo-derived cells, to obtain subpopulations of cells from heterogeneous mixtures of cells wherein the subpopulation of cells possess reduced differentiation potential compared to the original pluripotent stem cells and where the subpopulation is capable of being propagated.
• Herpes Virus-Based Compositions and Methods of Use in the Prenatal and Perinatal Periods
  申请人：Federoff Howard J.

  公开号：US20080226601A1

  公开（公告）日：2008-09-18

  Disclosed are compositions and methods for reducing the severity of a birth defect in a mammal by exposing the mammal (e.g., in utero) to a herpes virus amplicon particle comprising a cis element-flanked transgene and a sequence encoding a transposase. Upon expression, the transposase inserts the transgene into the genome of a cell (e.g., a neuron) within the mammal and the transgene expresses a polypeptide or RNA that compensates for a protein or gene defect that is causally associated with the birth defect.