2-bromo-3-n-pentylaminopropionitrile hydrochloride | 75984-84-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-bromo-3-n-pentylaminopropionitrile hydrochloride
• 英文别名: 2-Bromo-3-n-pentylaminopropionitrile hydrochloride；2-bromo-3-(pentylamino)propanenitrile;hydrochloride
• CAS: 75984-84-8
• 化学式: C₈H₁₅BrN₂*ClH
• 分子量: 255.585
• InChiKey: CKSHXAQMFOFTIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.48
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  35.8
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-bromo-3-n-pentylaminopropionitrile hydrochloride 、 三乙醇胺 以gives 2-cyano-n-pentylaziridine的产率得到2-Cyano-n-pentylaziridine
  参考文献：
  名称：

  N-Substituted aziridine-2-carboxylic acid derivatives and

  摘要：

  式为##STR1##的Aziridine-2-羧酸衍生物，其中X为羧基、腈基、烷氧羰基或氨基甲酰基基团，R和R.sup.1为各种有机基团；或其药理学上可接受的盐，表现出显著的免疫刺激活性，特别是与添加的化疗药物如青霉素、头孢菌素、硝基呋喃或氯霉素一起使用。其中X为氰基或烷氧羰基基团，R.sub.1为氢原子，但R'不是未取代的烷基基团或被羟基、烷氧基、二烷基氨基、苯基、4-氯苯基或4-甲氧基苯基或被苯基或甲基基团取代的乙烯基基团，或环烷基基团、苯基、4-氯苯基、4-甲氧基苯基、s-三嗪基或吡啶基；或X为氨基甲酰基基团，R.sub.1为氢原子，R'不是未取代的环己基、烷基或苄基基团；或X为氰基或烷氧羰基基团，R.sub.1为苯基基团，R'不是异丙基、环己基、苯基、苄基或对氯苯基基团；或R.sub.1为甲基基团，R.sup.1不是苯基、对氯苯基或对甲氧基苯基基团。

  公开号：

  US04409236A1

文献信息

• N-Substituted aziridine-2-carboxylic acid derivatives for immuno
  申请人：Boehringer Mannheim GmbH

  公开号：US04321194A1

  公开（公告）日：1982-03-23

  Aziridine-2-carboxylic acid derivatives of the formula ##STR1## wherein X is a carboxyl, nitrile, alkoxycarbonyl or carbamoyl group, and R and R.sup.1 are various organic radicals, or pharmacologically acceptable salts thereof, exhibit marked immunostimulant activity, especially in conjunction with added chemotherapeutic agents such as a penicillin, a cephalosporin, a nitrofuran or chloramphenicol. Those compounds are new where X is a cyano group or an alkoxycarbonyl radical and R.sub.1 is a hydrogen atom, but R' is not an unsubstituted alkyl radical or an alkyl radical substituted by hydroxyl, alkoxy, dialkylamino, phenyl, 4-chlorophenyl or 4-methoxyphenyl or a vinyl radical substituted by a phenyl or methyl radical, or a cycloalkyl radical, a phenyl a 4-chlorophenyl, a 4-methoxyphenyl, an s-triazinyl or a pyridinyl radical; or where X is a carbamoyl group and R.sub.1 is a hydrogen atom, R' is not an unsubstituted cyclohexyl, alkyl or benzyl radical; or where X is a cyano group or an alkoxycarbonyl radical and R.sub.1 is a phenyl radical, R' is not an isopropyl, cyclohexyl, phenyl, benzyl or p-chlorobenzyl radical; or where R.sub.1 is a methyl radical, R.sup.1 is not a benzyl, p-chloro- or p- methoxybenzyl radical.

  Aziridine-2-羧酸衍生物的化学式为##STR1## 其中X为羧基、腈基、烷氧羰基或氨基甲酰基，R和R.sup.1为各种有机基，或其药理学上可接受的盐，表现出明显的免疫刺激活性，特别是与添加的化疗药物如青霉素、头孢菌素、硝基呋喃或氯霉素结合使用时。这些化合物是新的，其中X为氰基或烷氧羰基基团，R.sub.1为氢原子，但R'不是未取代的烷基基团或被羟基、烷氧基、二烷基氨基、苯基、4-氯苯基或4-甲氧基苯基取代的烷基基团，或被苯基或甲基基团取代的乙烯基基团，或被环烷基基团、苯基、4-氯苯基、4-甲氧基苯基、s-三嗪基或吡啶基团取代的乙烯基基团；或X为氨基甲酰基基团且R.sub.1为氢原子时，R'不是未取代的环己基、烷基或苄基基团；或X为氰基或烷氧羰基基团且R.sub.1为苯基时，R'不是异丙基、环己基、苯基、苄基或对氯苄基基团；或R.sub.1为甲基基团时，R.sup.1不是苄基、对氯苄基或对甲氧基苄基基团。
• N-Substituted aziridine-2-carboxylic acid derivatives and
  申请人：Boehringer Mannheim GmbH

  公开号：US04409236A1

  公开（公告）日：1983-10-11

  Aziridine-2-carboxylic acid derivatives of the formula ##STR1## wherein X is a carboxyl, nitrile, alkoxycarbonyl or carbamoyl group, and R and R.sup.1 are various organic radicals; or pharmacologically acceptable salts thereof, exhibit marked immunostimulant activity, especially in conjunction with added chemotherapeutic agents such as a penicillin, a cephalosporin, a nitrofuran or chloramphenicol. Those compounds are new where X is a cyano group or an alkoxycarbonyl radical and R.sub.1 is a hydrogen atom, but R' is not an unsubstituted alkyl radical or an alkyl radical substituted by hydroxyl, alkoxy, dialkylamino, phenyl, 4-chlorophenyl or 4-methoxyphenyl or a vinyl radical substituted by a phenyl or methyl radical, or a cycloalkyl radical, a phenyl, a 4-chlorophenyl, a 4-methoxyphenyl, an s-triazinyl or a pyridinyl radical; or where X is a carbamoyl group and R.sub.1 is a hydrogen atom, R' is not an unsubstituted cyclohexyl, alkyl or benzyl radical; or where X is a cyano group or an alkoxycarbonyl radical and R.sub.1 is a phenyl radical, R' is not an isopropyl, cyclohexyl, phenyl, benzyl or p-chlorobenzyl radical; or where R.sub.1 is a methyl radical, R.sup.1 is not a benzyl, p-chloro- or p- methoxybenzyl radical.

  式为##STR1##的Aziridine-2-羧酸衍生物，其中X为羧基、腈基、烷氧羰基或氨基甲酰基基团，R和R.sup.1为各种有机基团；或其药理学上可接受的盐，表现出显著的免疫刺激活性，特别是与添加的化疗药物如青霉素、头孢菌素、硝基呋喃或氯霉素一起使用。其中X为氰基或烷氧羰基基团，R.sub.1为氢原子，但R'不是未取代的烷基基团或被羟基、烷氧基、二烷基氨基、苯基、4-氯苯基或4-甲氧基苯基或被苯基或甲基基团取代的乙烯基基团，或环烷基基团、苯基、4-氯苯基、4-甲氧基苯基、s-三嗪基或吡啶基；或X为氨基甲酰基基团，R.sub.1为氢原子，R'不是未取代的环己基、烷基或苄基基团；或X为氰基或烷氧羰基基团，R.sub.1为苯基基团，R'不是异丙基、环己基、苯基、苄基或对氯苯基基团；或R.sub.1为甲基基团，R.sup.1不是苯基、对氯苯基或对甲氧基苯基基团。
• US4321194A
  申请人：——

  公开号：US4321194A

  公开（公告）日：1982-03-23
• US4410532A
  申请人：——

  公开号：US4410532A

  公开（公告）日：1983-10-18
• US4409236A
  申请人：——

  公开号：US4409236A

  公开（公告）日：1983-10-11