4-(萘-1-基甲基)-1-甲基哌嗪 | 101586-24-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 4-(萘-1-基甲基)-1-甲基哌嗪
• 英文名称: 4-(naphthalen-1-ylmethyl)-1-methylpiperazine
• 英文别名: 1-methyl-4-[1]naphthylmethyl-piperazine；1-Methyl-4-[1]naphthylmethyl-piperazin；1-Methyl-4-(naphthalen-1-ylmethyl)piperazine
• CAS: 101586-24-7
• 化学式: C₁₆H₂₀N₂
• mdl: MFCD00811302
• 分子量: 240.348
• InChiKey: QSJSECFFIRGPKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.375
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (氯甲基)萘 在 聚合甲醛 、 乙醇 作用下， 生成 4-(萘-1-基甲基)-1-甲基哌嗪
  参考文献：
  名称：

  Histamine Antagonists. II.¹ Unsymmetrical 1,4-Disubstituted Piperazines

  摘要：

  DOI：

  10.1021/ja01176a038

文献信息

• Aminoquinoline Derived Heat Shock Protein 90 Inhibitors, Methods Of Preparing Same, And Methods For Their Use
  申请人：Sun Aiming

  公开号：US20110281908A1

  公开（公告）日：2011-11-17

  Novel classes of molecular chaperone Heat shock protein 90 (Hsp90) inhibitors and methods for making these classes are provided herein. These compounds are useful in treating and preventing cancer and other Hsp90-related diseases, such as inflammation and neurodegenerative disorders. Also provided herein are methods of treating and preventing cancer and other Hsp90 related disease. The methods include administering to a subject a therapeutically effective amount of an Hsp90 inhibitor.

  本文提供了新型分子伴侣热休克蛋白90（Hsp90）抑制剂的类别和制备方法。这些化合物可用于治疗和预防癌症和其他与Hsp90相关的疾病，如炎症和神经退行性疾病。本文还提供了治疗和预防癌症和其他Hsp90相关疾病的方法。该方法包括向患者施用治疗有效量的Hsp90抑制剂。
• Cross-Coupling of Mesylated Phenol Derivatives with Potassium Ammonio- and Amidomethyltrifluoroborates
  作者：Gary A. Molander、Floriane Beaumard

  DOI：10.1021/ol200128y

  日期：2011.3.4

  A large array of aryl and heteroaryl mesylates have been successfully employed as electrophiles in a Csp(2)-Csp(3) Suzuki-Miyaura cross-coupling with potassium ammonio- and amidomethyltrifluoroborates to afford the corresponding products in high yields.
• UNSYMMETRICALLY DISUBSTITUTED PIPERAZINES. II. HISTAMINE ANTAGONISTS¹
  作者：LEWIS P. ALBRO、RICHARD BALTZLY、ARTHUR P. PHILLIPS

  DOI：10.1021/jo01157a008

  日期：1949.9
• Histamine Antagonists. II.¹ Unsymmetrical 1,4-Disubstituted Piperazines
  作者：K. E. Hamlin、Arthur W. Weston、Francis E. Fischer、R. J. Michaels

  DOI：10.1021/ja01176a038

  日期：1949.8