5-Oxo-3-phenylchromeno[4,3-b]pyridine-2-carboxylic acid | 1027305-87-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 5-Oxo-3-phenylchromeno[4,3-b]pyridine-2-carboxylic acid
• CAS: 1027305-87-8
• 化学式: C₁₉H₁₁NO₄
• 分子量: 317.301
• InChiKey: YPCWJLFPCRVUMQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  76.5
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  重氮甲烷 、 5-Oxo-3-phenylchromeno[4,3-b]pyridine-2-carboxylic acid 以 乙醚 为溶剂， 以0.26 g的产率得到methyl 3-phenyl-5-oxo-benzopyrano[4,3-b]pyridine-2-carboxylate
  参考文献：
  名称：

  Synthesis of Aza Polycyclic Compounds Derived from Pyrrolidine, Indolizidine, and Indole via Intramolecular Diels−Alder Cycloadditions of Neutral 2-Azadienes

  摘要：

  A method for the preparation of novel oxaza and diaza polycyclic 9-oxa-4-azaphenanthrene, 5H-pyrido[2,3-alpha]pyrrolizine, 5H,6H-pyrido[3,2-g]indolizine, and 5H,6H-indeno[2,1-alpha]indole is described, based on tandem reactions: aza-Wittig reaction of N-vinylic phosphazenes with functionalized aldehydes and an intramolecular aza-Diels-Alder reaction.

  DOI：

  10.1021/jo016325v
• 作为产物：
  描述：

  2-(2-丙炔氧基)苯甲醛 在 ruthenium trichloride 、 sodium periodate 作用下， 以 四氯化碳 、 氯仿 、 水 、 乙腈 、 xylene 为溶剂， 反应 41.0h， 生成 5-Oxo-3-phenylchromeno[4,3-b]pyridine-2-carboxylic acid
  参考文献：
  名称：

  Synthesis of Aza Polycyclic Compounds Derived from Pyrrolidine, Indolizidine, and Indole via Intramolecular Diels−Alder Cycloadditions of Neutral 2-Azadienes

  摘要：

  A method for the preparation of novel oxaza and diaza polycyclic 9-oxa-4-azaphenanthrene, 5H-pyrido[2,3-alpha]pyrrolizine, 5H,6H-pyrido[3,2-g]indolizine, and 5H,6H-indeno[2,1-alpha]indole is described, based on tandem reactions: aza-Wittig reaction of N-vinylic phosphazenes with functionalized aldehydes and an intramolecular aza-Diels-Alder reaction.

  DOI：

  10.1021/jo016325v

文献信息

• Synthesis of Aza Polycyclic Compounds Derived from Pyrrolidine, Indolizidine, and Indole via Intramolecular Diels−Alder Cycloadditions of Neutral 2-Azadienes
  作者：Francisco Palacios、Concepción Alonso、Patricia Amezua、Gloria Rubiales

  DOI：10.1021/jo016325v

  日期：2002.3.1

  A method for the preparation of novel oxaza and diaza polycyclic 9-oxa-4-azaphenanthrene, 5H-pyrido[2,3-alpha]pyrrolizine, 5H,6H-pyrido[3,2-g]indolizine, and 5H,6H-indeno[2,1-alpha]indole is described, based on tandem reactions: aza-Wittig reaction of N-vinylic phosphazenes with functionalized aldehydes and an intramolecular aza-Diels-Alder reaction.