N,N'-bis(2-aminoethyl)ethane-1,1-diamine | 1058186-37-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N'-bis(2-aminoethyl)ethane-1,1-diamine
• 英文别名: 1-N,1-N'-bis(2-aminoethyl)ethane-1,1-diamine
• CAS: 1058186-37-0
• 化学式: C₆H₁₈N₄
• 分子量: 146.236
• InChiKey: JMYKVHSBQONMNK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  76.1
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  聚合甲醛 、 N,N'-bis(2-aminoethyl)ethane-1,1-diamine 在 盐酸 、 sodium sulfide 作用下， 以 水 为溶剂， 反应 3.0h， 以69%的产率得到3,5-bis[-(1,3,5-dithiazinan-5-yl)ethyl]-4-methyl-1,3,5-thiadiazinane
  参考文献：
  名称：

  Cyclothiomethylation of aliphatic polyamines with formaldehyde and hydrogen sulfide

  摘要：

  Cyclothiomethylation of the terminal amino groups in N-(2-aminoethyl)ethane-1,2-diamine, N,N'-bis(2-aminoethyl)ethane-1,2-diamine, and N,N'-bis(2-aminoethyl)ethane-1,1-diamine with formaldehyde and hydrogen sulfide gave the corresponding bis-1,3,5-dithiazinane derivatives. The reaction in aqueous butanol at 0 degrees C was accompanied by intermolecular thiomethylation at the secondary amino groups with formation of previously unknown polyheterocyclic compounds containing nitrogen and sulfur atoms.

  DOI：

  10.1134/s1070428008040052

文献信息

• Synthesis of triethylenetetramines
  申请人：Jonas Marco

  公开号：US20060041170A1

  公开（公告）日：2006-02-23

  Methods and intermediates for synthesizing triethylenetetramine and salts thereof, as well as novel triethylenetetramine salts and their crystal structure, and triethylenetetramine salts of high purity.

  合成三乙烯四胺及其盐的方法和中间体，以及新型三乙烯四胺盐及其晶体结构，以及高纯度的三乙烯四胺盐。
• Synthesis Of Triethylenetetramines
  申请人：Jonas Marco

  公开号：US20120029203A1

  公开（公告）日：2012-02-02

  Methods and intermediates for synthesizing triethylenetetramine and salts thereof, as well as novel triethylenetetramine salts and their crystal structure, and triethylenetetramine salts of high purity.

  合成三乙烯四胺及其盐的方法和中间体，以及新型三乙烯四胺盐及其晶体结构，以及高纯度的三乙烯四胺盐。
• Synthesis of Triethylenetetramines
  申请人：PhilEra New Zealand Limited

  公开号：US20150057466A1

  公开（公告）日：2015-02-26

  Methods and intermediates for synthesizing triethylenetetramine and salts thereof, as well as novel triethylenetetramine salts and their crystal structure, and triethylenetetramine salts of high purity.

  合成三乙烯四胺及其盐的方法和中间体，以及新型三乙烯四胺盐及其晶体结构和高纯度的三乙烯四胺盐。
• Use of trientine to deliver copper to ischemic tissue
  申请人：INNOLIFE CO., LTD.

  公开号：US11033579B2

  公开（公告）日：2021-06-15

  Methods of ischemic tissue repair and regeneration through promoting tissue redistribution and reuse of copper by administering a composition comprising a copper chelating tetramine, such as trientine. Methods and compositions for increasing intracellular copper lever and/or inducing repair of an ischemic tissue in an individual. Increased copper level in an ischemic tissue may promote copper-dependent HIF-1 transcriptional activities and tissue repair.

  通过施用包含铜螯合四胺（如三尖杉碱）的组合物，促进组织铜的再分布和再利用，从而实现缺血组织修复和再生的方法。增加细胞内铜杠杆和/或诱导缺血组织修复的方法和组合物。缺血组织中铜含量的增加可促进铜依赖性 HIF-1 转录活动和组织修复。
• Copper chelators for treating ocular inflammation
  申请人：——

  公开号：US20030055113A1

  公开（公告）日：2003-03-20

  In various aspects, the invention provides methods for treating ocular inflammation using copper chelating compounds, such as compounds other than D-penicillamine. In some embodiments, such compounds may be polyamines, such as triethylenetetramine or tetraethylenepentamine. For example, the present invention provides methods for treating inflammation secondary to ocular laser therapy.

  在各个方面，本发明提供了使用铜螯合化合物（如 D-青霉胺以外的化合物）治疗眼部炎症的方法。在某些实施方案中，此类化合物可以是多胺，例如三乙烯四胺或四乙烯五胺。例如，本发明提供了治疗继发于眼部激光治疗的炎症的方法。