(+/-)-2-hydroxy-3-(4-hydroxy-3,5-diiodo-phenyl)-propionic acid | 15220-05-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: (+/-)-2-hydroxy-3-(4-hydroxy-3,5-diiodo-phenyl)-propionic acid
• 英文别名: 2-hydroxy-3-(4-hydroxy-3,5-diiodo-phenyl)-propionic acid；2-Hydroxy-3-(4-hydroxy-3,5-dijod-phenyl)-propionsaeure；(+/-)-2-Hydroxy-3-(4-hydroxy-3,5-dijod-phenyl)-propionsaeure；3-(3',5'-diiodo-4'-hydroxyphenyl) lactic acid；3-(4-Hydroxy-3,5-diiodophenyl)lactic acid；2-hydroxy-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid
• CAS: 15220-05-0
• 化学式: C₉H₈I₂O₄
• 分子量: 433.969
• InChiKey: ZPJHINFPRQWKIH-UHFFFAOYSA-N

物化性质

• 溶解度：
  可溶于二甲基甲酰胺；二甲基亚砜;甲醇
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (+/-)-2-hydroxy-3-(4-hydroxy-3,5-diiodo-phenyl)-propionic acid 、 alkaline earth salt of/the/ methylsulfuric acid 生成 DL-4-羟基苯乳酸
  参考文献：
  名称：

  Foster; Gutman, Journal of Biological Chemistry, 1930, vol. 87, p. 289,292

  摘要：

  DOI：
• 作为产物：
  描述：

  DL-4-羟基苯乳酸 在 硫酸 、 碘酸 、 potassium iodide 作用下， 生成 (+/-)-2-hydroxy-3-(4-hydroxy-3,5-diiodo-phenyl)-propionic acid
  参考文献：
  名称：

  Saul; Trikojus, Biochemical Journal, 1948, vol. 42, p. 80

  摘要：

  DOI：

文献信息

• Methods for treating of skin conditions with retinoid double conjugate compounds
  申请人：US COSMECEUTECHS LLC

  公开号：US10123960B2

  公开（公告）日：2018-11-13

  A double conjugate molecule made of a retinoid, an organic acid, particularly an a-hydroxy acid, and an alcohol or acyl group, is provided which is useful in treating skin conditions, particularly aging. The retinoid, organic acid, and alcohol/acyl group are preferably linked via ester bonds.

  提供一种由视黄醇、有机酸（特别是α-羟基酸）和醇或酰基组成的双共轭分子，可用于治疗皮肤状况，特别是衰老。视黄醇、有机酸和醇/酰基组最好通过酯键连接。
• Flumazenil abolishes midazolam-induced increase in the work of nasal breathing
  作者：Yasuko Kawauchi、Tsutomu Oshima、Yuhji Saitoh、Hidenori Toyooka

  DOI：10.1007/bf03019871

  日期：2000.12

  Purpose: To evaluate the effects of midazolam sedation followed by flumazenil antagonism on the work of nasal breathing in normal humans.Methods: We measured minute ventilation through the nasal route, respiratory frequency, nasal resistance (R-n) and the work of nasal breathing under three conditions: awake, during midazolam sedation, and after flumazenil antagonism in eight healthy human subjects. A custom-made, partitioned face mask enabled nasal and oral airflow to be measured separately. To calculate R-n and the work of nasal breathing, nasal mask and oropharyngeal pressure was also measured.Results: Total resistive work spent on the upstream segment of the nasal route per minute (W-n) (J.min(-1)) was greater during midazolam sedation (3.6 +/- 2.9) than while awake (1.6 +/- 0.9) and after flumazenil antagonism (1.7 +/- 0.6), respectively (mean +/- SD) (P < 0.05). Total resistive work spent on the upstream segment of nasal breathing (W-n/V-nE) (J.L-1) increased from 0.31 +/- 0.14 to 0.75 +/- 0.61 after midazolam administration (P < 0.05) and decreased to 0.31 +/- 0.10 after flumazenil. Following midazolam administration, a strong correlation was observed between changes in W-n/V-nE and changes in (R-n r = 0.852, P < 0.0001), whereas there was no correlation between changes in W-n and changes in (R-n = 0.159, P = 0.279).Conclusion: The work of breathing spent on the upstream segment of the nasal route increases during midazolam sedation and returns to baseline after flumazenil antagonism.
• RETINOID DOUBLE CONJUGATE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS FOR TREATING OF SKIN CONDITIONS
  申请人：US CosmeceuTechs LLC

  公开号：EP3068495A1

  公开（公告）日：2016-09-21
• US4363815A
  申请人：——

  公开号：US4363815A

  公开（公告）日：1982-12-14
• [EN] RETINOID DOUBLE CONJUGATE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS FOR TREATING OF SKIN CONDITIONS<br/>[FR] COMPOSÉS RÉTINOÏDES DE TYPE DOUBLE CONJUGUÉ, COMPOSITIONS LES CONTENANT, ET MÉTHODES DE TRAITEMENT DES AFFECTIONS CUTANÉES
  申请人：US COSMECEUTECHS LLC

  公开号：WO2015073769A1

  公开（公告）日：2015-05-21

  A double conjugate molecule made of a retinoid, an organic acid, particularly an a- hydroxy acid, and an alcohol or acyl group, is provided which is useful in treating skin conditions, particularly aging. The retinoid, organic acid, and alcohol/acyl group are preferably linked via ester bonds.