tert-butyl 3-[(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)carbonyl]piperidine-1-carboxylate | 312738-60-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: tert-butyl 3-[(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)carbonyl]piperidine-1-carboxylate
• 英文别名: (+/-)-6,7-dimetoxy-2-{[1-(tertbutyloxycarbonyl)-3-piperidyl]carbonyl}-1,2,3,4-tetrahydroisoquinoline；(+/-)-6,7-Dimethoxy-2-{[1-(tert-butyloxycarbonyl)-3-piperidyl]carbonyl}-1,2,3,4-tetrahydroisoquinoline；tert-butyl 3-(6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl)piperidine-1-carboxylate
• CAS: 312738-60-6
• 化学式: C₂₂H₃₂N₂O₅
• 分子量: 404.506
• InChiKey: LPTNUCSJSXOWRA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  68.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  tert-butyl 3-[(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)carbonyl]piperidine-1-carboxylate 在 盐酸 作用下， 以 乙酸乙酯 为溶剂， 生成 (+/-)-6,7dimetoxy-2-[(3-piperidyl)carbonyl]-1,2,3,4-tetrahydroisoquinoline hydrochloride
  参考文献：
  名称：

  NOVEL ISOQUINOLINE DERIVATIVES OR SALTS THEREOF

  摘要：

  公开号：

  EP1186601B1
• 作为产物：
  描述：

  6,7-二甲氧基-1,2,3,4-四氢异喹啉 、 1-BOC-哌啶-3-羧酸 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 生成 tert-butyl 3-[(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)carbonyl]piperidine-1-carboxylate
  参考文献：
  名称：

  NOVEL ISOQUINOLINE DERIVATIVES OR SALTS THEREOF

  摘要：

  公开号：

  EP1186601B1

文献信息

• Isoquinoline derivatives or salts thereof
  申请人：——

  公开号：US06573279B1

  公开（公告）日：2003-06-03

  The compound of the present invention relates to a drug, particularly to a novel isoquinoline derivative or its salt having an If current inhibitory effect without serious side effects such as convulsion and also to a drug, particularly a cardiac rate lowering agent, containing the compound as the active ingredient. Namely, the compound has a current If inhibitory effect and is particularly useful as a cardiac rate lowering agent for preventing ischemic heart diseases such as angina and cardiac infarction and circulatory diseases such as congestive cardiac insufficiency and arrhythmia (supraventricular arrhythmia). The present invention relates to dialkoxy-1,2,3,4-tetrahydroquinoline-2-carbonylpiperidino-3,4-dialkoxypropaneanilide derivatives, etc.

  该发明涉及一种药物，特别是一种新型异喹啉衍生物或其盐，具有If电流抑制作用，且没有像惊厥一样严重的副作用，还涉及一种药物，特别是一种降低心率的药物，该药物以该化合物作为活性成分。换句话说，该化合物具有当前If抑制作用，特别适用于预防缺血性心脏病，如心绞痛和心肌梗死以及循环系统疾病，如充血性心力衰竭和心律失常（上室性心律失常）的心率降低剂。本发明涉及二烷氧基-1,2,3,4-四氢喹啉-2-羧酰基哌啶-3,4-二烷氧基丙酰胺衍生物等。
• Synthesis and pharmacological evaluation of N -acyl-1,2,3,4-tetrahydroisoquinoline derivatives as novel specific bradycardic agents
  作者：Hideki Kubota、Toshihiro Watanabe、Akio Kakefuda、Noriyuki Masuda、Kouichi Wada、Noe Ishii、Shuichi Sakamoto、Shinichi Tsukamoto

  DOI：10.1016/j.bmc.2003.12.032

  日期：2004.3

  A series of N-acyl-1,2,3,4-tetrahydroisoquinoline derivatives were synthesized and evaluated for their bradycardic activities in isolated guinea pig right atria and in urethane-anesthetized rats. These efforts resulted in identification of the compound 8a, which exhibits potent bradycardic activity with minimal influence on mean blood pressure in urethane-anesthetized rats. Oral administration of compound 8a to conscious rats revealed increased potency and prolonged duration of action when compared to Zatebradine. (C) 2004 Elsevier Ltd. All rights reserved.
• US6573279B1
  申请人：——

  公开号：US6573279B1

  公开（公告）日：2003-06-03
• NOVEL ISOQUINOLINE DERIVATIVES OR SALTS THEREOF
  申请人：YAMANOUCHI PHARMACEUTICAL CO. LTD.

  公开号：EP1186601B1

  公开（公告）日：2004-03-24