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12-{[4-(trifluoromethyl)phenyl]sulfonyl}-4,5,6,11-tetrahydro-2H-5,11-epiminobenzo[4,5]cycloocta[1,2-c]pyrazole | 1215182-31-2

中文名称
——
中文别名
——
英文名称
12-{[4-(trifluoromethyl)phenyl]sulfonyl}-4,5,6,11-tetrahydro-2H-5,11-epiminobenzo[4,5]cycloocta[1,2-c]pyrazole
英文别名
16-[4-(Trifluoromethyl)phenyl]sulfonyl-12,13,16-triazatetracyclo[7.6.1.02,7.011,15]hexadeca-2,4,6,11(15),13-pentaene;16-[4-(trifluoromethyl)phenyl]sulfonyl-12,13,16-triazatetracyclo[7.6.1.02,7.011,15]hexadeca-2,4,6,11(15),13-pentaene
12-{[4-(trifluoromethyl)phenyl]sulfonyl}-4,5,6,11-tetrahydro-2H-5,11-epiminobenzo[4,5]cycloocta[1,2-c]pyrazole化学式
CAS
1215182-31-2
化学式
C20H16F3N3O2S
mdl
——
分子量
419.427
InChiKey
DAJLKAHBVBBQHI-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    3.6
  • 重原子数:
    29
  • 可旋转键数:
    2
  • 环数:
    5.0
  • sp3杂化的碳原子比例:
    0.25
  • 拓扑面积:
    74.4
  • 氢给体数:
    1
  • 氢受体数:
    7

反应信息

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文献信息

  • US8283358B2
    申请人:——
    公开号:US8283358B2
    公开(公告)日:2012-10-09
  • [EN] N-SULFONAMIDO POLYCYCLIC PYRAZOLYL COMPOUNDS<br/>[FR] COMPOSÉS N-SULFONAMIDO PYRAZOLYLES POLYCYCLIQUES
    申请人:ELAN PHARM INC
    公开号:WO2010028213A2
    公开(公告)日:2010-03-11
    The current invention provides compounds having a structure according to Formulae (1), (2), (3), and (4): wherein the A-ring, B-ring, C-ring, m, n, R25, R50, and R51 are as described in the specification. The invention also provides pharmaceutical compositions comprising compounds of Formulae (1), (2), (3), and (4), as well as methods of treating cognitive disorders, such as Alzheimer's disease. The invention further provides intermediates useful in preparing the compounds of Formulae (1), (2), (3), and (4).
  • N-SULFONAMIDO POLYCYCLIC PYRAZOLYL COMPOUNDS
    申请人:Konradi Andrei W.
    公开号:US20100081680A1
    公开(公告)日:2010-04-01
    The current invention provides compounds having a structure according to Formulae 1, 2, 3, and 4: wherein the A-ring, B-ring, C-ring, m, n, R 25 , R 50 , and R 51 are as described in the specification. The invention also provides pharmaceutical compositions comprising compounds of Formulae 1, 2, 3, and 4, as well as methods of treating cognitive disorders, such as Alzheimer's disease. The invention further provides intermediates useful in preparing the compounds of Formulae 1, 2, 3, and 4.
    当前发明提供具有根据公式1、2、3和4结构的化合物:其中A环、B环、C环、m、n、R25、R50和R51如说明书所述。该发明还提供了包含公式1、2、3和4化合物的药物组合物,以及治疗认知障碍的方法,如阿尔茨海默病。该发明进一步提供了用于制备公式1、2、3和4化合物的有用的中间体。
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