4-(4-羟基-苯氧基)-丁酸 | 84822-51-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 4-(4-羟基-苯氧基)-丁酸
• 英文名称: 4-(4-hydroxyphenoxy)butanoic acid
• 英文别名: 4-(4-hydroxy-phenoxy)-butyric acid；4-(4-Hydroxy-phenoxy)-buttersaeure
• CAS: 84822-51-5
• 化学式: C₁₀H₁₂O₄
• 分子量: 196.203
• InChiKey: VGANCEWBFLKZBS-UHFFFAOYSA-N

物化性质

• 沸点：
  430.7±25.0 °C(Predicted)
• 密度：
  1.257±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-氨基-5-甲基噻唑 、 4-(4-羟基-苯氧基)-丁酸 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 16.0h， 以8%的产率得到4-(4-hydroxyphenoxy)-N-(5-methylthiazol-2-yl)butanamide
  参考文献：
  名称：

  Identification of 5-Substituted 2-Acylaminothiazoles That Activate Tat-Mediated Transcription in HIV-1 Latency Models

  摘要：

  The persistent reservoir of cells latently infected with human immunodeficiency virus (HIV)-integrated proviral DNA necessitates lifelong suppressive antiretroviral therapy (ART). Epigenetic targeted compounds have shown promise as potential latency-reversing agents; however, these drugs have undesirable toxicity and lack specificity for HIV. We utilized a novel HEK293-derived FlpIn dual-reporter cell line, which quantifies specific HIV provirus reactivation (LTR promoter) relative to nonspecific host cell gene expression (CMV promoter), to identify the 5-substituted 2-acylaminothiazole hit class. Here, we describe the optimization of the hit class, defining the functionality necessary for HIV gene activation and for improving in vitro metabolism and solubility. The optimized compounds displayed enhanced HIV gene expression in HEK293 and Jurkat 10.6 latency cellular models and increased unspliced HIV RNA in resting CD4+ T cells isolated from HIV-infected individuals on ART, demonstrating the potential of the 2-acylaminothiazole class as latency-reversing agents.

  DOI：

  10.1021/acs.jmedchem.9b00462
• 作为产物：
  描述：

  4-(4-hydroxyphenoxy)butanenitrile 生成 4-(4-羟基-苯氧基)-丁酸
  参考文献：
  名称：

  Byrde; Woodcock, Biochemical Journal, 1957, vol. 65, p. 682,683

  摘要：

  DOI：

文献信息

• p-Hydroxyphenoxy Aliphatic Acids
  作者：Harry Sobotka、John Austin

  DOI：10.1021/ja01135a028

  日期：1952.8
• Electrolyte compositions
  申请人：DAINICHISEIKA COLOR & CHEMICALS MFG. CO. LTD.

  公开号：EP1403948B1

  公开（公告）日：2010-07-28
• BIOCOMPATIBLE POLYMERS FOR MEDICAL DEVICES
  申请人：Rutgers, The State University of New Jersey

  公开号：EP2459637A1

  公开（公告）日：2012-06-06
• ELECTROLYTE COMPOSITIONS
  申请人：Nakamura Michiei

  公开号：US20100036060A1

  公开（公告）日：2010-02-11

  Ion-conducting (co)polymer media and ion-conducting oligomer media close in ion conductivity to organic-solvent-based electrolytes can be produced easily and safely on industrial scale. These ion-conducting (co)polymer media use (co)polymers containing at least one cyclocarbonato group, and these ion-conducting oligomer media employ oligomers containing at least two cyclocarbonato groups.
• US5277895A
  申请人：——

  公开号：US5277895A

  公开（公告）日：1994-01-11