4-methylpiperazine-1-carboxamidine hydrochloride | 861429-91-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-methylpiperazine-1-carboxamidine hydrochloride
• 英文别名: 4-Methyl-1-piperazincarboxamidin-hydrochlorid；4-Methylpiperazine-1-carboximidamide;hydrochloride
• CAS: 861429-91-6
• 化学式: C₆H₁₄N₄*ClH
• 分子量: 178.665
• InChiKey: OYKWOHGUJBQZJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.45
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  56.4
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-methylpiperazine-1-carboxamidine hydrochloride 在 sodium ethanolate 作用下， 以 乙醇 为溶剂， 反应 0.5h， 生成 4-甲基哌嗪-1-羧脒
  参考文献：
  名称：

  �ber N1- und N2-substituierte 2-Amino-5,6-dihydro-4(1H)-pyrimidinone

  摘要：

  DOI：

  10.1007/bf00798460

文献信息

• Antimalarial activity and synthesis of new trisubstituted pyrimidines
  作者：Anu Agarwal、Kumkum Srivastava、S.K. Puri、Prem M.S. Chauhan

  DOI：10.1016/j.bmcl.2005.04.014

  日期：2005.6

  A series of 2,4,6-trisubstituted-pyrimidines was synthesized and evaluated for their in vitro antimalarial activity against Plasmodium falciparum. Out of the 30 compounds synthesized 21 compounds showed MIC in the range of 0.5-2 microg/mL. These compounds are in vitro several folds more active than pyrimethamine.

  合成了一系列的2,4,6-三取代-嘧啶并评估了它们对恶性疟原虫的体外抗疟活性。在合成的30种化合物中，有21种化合物的MIC在0.5-2 microg / mL范围内。这些化合物在体外的活性是乙胺嘧啶的几倍。
• Solid support synthesis of 6-aryl-2-substituted pyrimidin-4-yl phenols as anti-infective agents
  作者：Anu Agarwal、Kumkum Srivastava、S.K. Puri、S. Sinha、Prem M.S. Chauhan

  DOI：10.1016/j.bmcl.2005.08.020

  日期：2005.11

  A library of 30 trisubstituted pyrimidines were synthesized and evaluated for their in vitro antimalarial and antitubercular activity. Out of the 30 compounds synthesized, 23 compounds have shown in vitro antimalarial activity against Plasmodium falciparum in the range of 0.25-2 microg/mL and 16 compounds have shown antitubercular activity against Mycobacterium tuberculosis H37Ra, at a concentration

  合成了30个三取代嘧啶的文库，并对其体外抗疟和抗结核活性进行了评估。在合成的30种化合物中，有23种化合物对恶性疟原虫的体外抗疟活性为0.25-2 microg / mL，在浓度为25 microg / mL的情况下，有16种化合物对结核分枝杆菌H37Ra具有抗结核活性。
• Synthesis of substituted indole derivatives as a new class of antimalarial agents
  作者：Anu Agarwal、Kumkum Srivastava、S.K. Puri、Prem M.S. Chauhan

  DOI：10.1016/j.bmcl.2005.04.011

  日期：2005.6

  A series of substituted indole derivatives were synthesized and evaluated for their in vitro antimalarial activity against P. falciparum. Out of the 24 compounds synthesized six compounds have shown MIC of 1 mu g/mL. These compounds are in vitro several folds more active than pyrimethamine. (c) 2005 Elsevier Ltd. All rights reserved.