5-methylhex-5-en-2-amine | 13296-29-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 5-methylhex-5-en-2-amine
• 英文别名: (1,4-Dimethyl-pent-4-enyl)-amin
• CAS: 13296-29-2
• 化学式: C₇H₁₅N
• 分子量: 113.203
• InChiKey: RGQPKWZHUHUZPW-UHFFFAOYSA-N

物化性质

• 沸点：
  125-126 °C
• 密度：
  0.791±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  5-methylhex-5-en-2-amine 在 吡啶 、 溴 作用下， 以 二氯甲烷 为溶剂， 生成 Benz-(4,5-dibromo-1,4-dimethylpentyl)-amid
  参考文献：
  名称：

  Black,D.S.C.; Doyle,J.E., Australian Journal of Chemistry, 1978, vol. 31, p. 2247 - 2257

  摘要：

  DOI：
• 作为产物：
  描述：

  5-甲基-5-己烯-2-酮 生成 5-methylhex-5-en-2-amine
  参考文献：
  名称：

  Black,D.S.C.; Doyle,J.E., Australian Journal of Chemistry, 1978, vol. 31, p. 2247 - 2257

  摘要：

  DOI：

文献信息

• The stereochemistry of organometallic compounds
  作者：Despina Anastasiou、W.Roy Jackson

  DOI：10.1016/0022-328x(91)80065-r

  日期：1991.8

  Rhodium-catalysed reactions of 5-aminopent-1-enes with carbon monoxide and hydrogen give 2-piperidinone derivatives in high yields under mild conditions. Reaction of allylamine under similar conditions gave exclusively 2-pyrrolidone in high yield and reactions of 4-aminobut-1-enes gave mixtures of 2-piperidinones and 2-pyrrolidinones. The role of the hydrogen in these reactions is discussed.

  铑在5-氨基戊-1-烯与一氧化碳和氢的催化下，在温和的条件下以高收率得到2-哌啶酮衍生物。烯丙胺在相似条件下的反应仅以高收率得到了2-吡咯烷酮，而4-氨基丁-1-烯的反应则得到了2-哌啶酮和2-吡咯烷酮的混合物。讨论了氢在这些反应中的作用。
• Compositions containing aminoalkanes and aminoalkane derivatives
  申请人：Bromley Philip J.

  公开号：US20100041622A1

  公开（公告）日：2010-02-18

  Provided are palatable liquid compositions that contain 2-aminoalkanes that have vasoconstrictor activity, and other additives, including taste-modifying agents. Also provided are methods for making and using the compositions to provide stimulant activity for increasing energy, alertness, endurance, and/or any other consequent physical manifestation of the vasoconstrictor activity.

  提供的是可口的液体组合物，其中包含具有血管收缩活性的2-氨基烷，以及其他添加剂，包括口味调节剂。还提供了制备和使用这些组合物的方法，以提供刺激活性，增加能量，警觉性，耐力和/或任何其他血管收缩活性的体现。
• BALCK D. S. C.; DOYLE J. E., AUSTRAL. J. CHEM., 1978, 31, NO 10, 2247-2257
  作者：BALCK D. S. C.、 DOYLE J. E.

  DOI：——

  日期：——
• [EN] NOVEL METHOD AND APPLICATION OF UNSYMMETRICALLY MESO-SUBSTITUTED PORPHYRINS AND CHLORINS FOR PDT<br/>[FR] NOUVEAU PROCÉDÉ ET APPLICATION DE PORPHYRINES MÉSO-SUBSTITUÉES DE FAÇON NON SYMÉTRIQUE ET DE CHLORINES POUR THÉRAPIE PHOTODYNAMIQUE
  申请人：CERAMOPTEC IND INC

  公开号：WO2010033678A2

  公开（公告）日：2010-03-25

  Biologically active compounds that can be used as photosensitizers for diagnostic and therapeutic applications, particularly for PDT of cancer, infections and other hyperproiiferative diseases, fluorescence diagnosis and PDT treatment of a non- turaorous indication such as arthritis, inflammatory diseases, viral or bacterial infections, dermatological, opthamologica! or urological disorders are provided as well as providing methods to obtain them in pharmaceutical quality. One embodiment consists of a method to synthesize a porphyrin with a defined arrangement of meso- substituents and then converting this porphyrin system to a chlorin system by dihydroxylation or reduction, and if more than one isomer is formed separate them by chromatography either on normal or reversed phase silica. In another embodiment the substituents on the porphyrin are selected to direct the reduction or dihydroxylation to the chlorin so that a certain isomer is selectively formed. Another embodiment is to provide amphiphilic compounds with a higher membrane affinity and increased PDT- efficacy. In another embodiment a method to reductsvely cleave the osmate(VΪ)ester avoiding the use of gaseous H2S is provided. In another embodiment substituents are identified that via their steric and/or electronic influence direct the dihydroxylation or reduction with diimine so that one isomer is favored. Another embodiment consists of formulate the desired isomer into a liposomal formulation to be injected avoiding undesirable effects like solubility problems or delayed pharmacokinetics of the tetrapyrrole systems.
• Black,D.S.C.; Doyle,J.E., Australian Journal of Chemistry, 1978, vol. 31, p. 2247 - 2257
  作者：Black,D.S.C.、Doyle,J.E.

  DOI：——

  日期：——