1-Methyl-1-n-propyl-n-hexylamine | 65580-71-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-Methyl-1-n-propyl-n-hexylamine
• 英文别名: 4-Amino-4-methylnonan；4-Methylnonan-4-amine
• CAS: 65580-71-4
• 化学式: C₁₀H₂₃N
• 分子量: 157.299
• InChiKey: WXGFQASKEPYNRZ-UHFFFAOYSA-N

物化性质

• 沸点：
  203.4±8.0 °C(Predicted)
• 密度：
  0.797±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-甲基-4-壬醇 生成 1-Methyl-1-n-propyl-n-hexylamine
  参考文献：
  名称：

  Pigerol; Vernieres; Broll, European Journal of Medicinal Chemistry, 1977, vol. 12, # 4, p. 351 - 359

  摘要：

  DOI：

文献信息

• Beta-secretase modulators and methods of use
  申请人：Albrecht K. Brian

  公开号：US20070185103A1

  公开（公告）日：2007-08-09

  The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A, B, R 3 , R 4 , R 5 , i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.

  本发明涉及一类新的化合物，用于调节Beta-分泌酶酶活性和治疗Beta-分泌酶介导的疾病，包括阿尔茨海默病（AD）和相关疾病。 在一种实施方式中，该化合物具有一般式I，其中A，B，R3，R4，R5，i和j在此定义。 本发明还包括包括一种或多种I式化合物的制药组合物，以及使用这些化合物的方法，包括通过向受体注射I式化合物或包含它们的组合物来治疗AD和相关疾病。 本发明还包括II式和III式的进一步实施方式，以及用于制备本发明化合物的中间体和过程。
• Tertiary alkyl primary amines and process for preparing the same
  申请人：ROHM AND HAAS COMPANY

  公开号：EP0890570A2

  公开（公告）日：1999-01-13

  A C8-C10 branched tertiary alkyl primary amine mixture is disclosed which is useful as a multi-functional additive in fuels, lubricants, and dyes. The subject amines are prepared by reacting an acid, a nitrile, a C8-C10 substrate in the presence of water to form a first intermediate product; further reacting the first intermediate with an acid in the presence of water to form a second intermediate product and neutralizing the second intermediate with a basic compound to form the product.

  本发明公开了一种 C8-C10 支化叔烷基伯胺混合物，可用作燃料、润滑剂和染料中的多功能添加剂。这种胺的制备方法是：将酸、腈、C8-C10 底物在有水的情况下反应，形成第一中间产物；再将第一中间产物与酸在有水的情况下反应，形成第二中间产物，然后用碱性化合物中和第二中间产物，形成产品。
• S1PR4-TARGETING COMPOSITION FOR PREVENTING OR TREATING NON-ALCOHOLIC STEATOHEPATITIS
  申请人：University Of Ulsan Foundation For Industry Cooperation

  公开号：EP3603636A1

  公开（公告）日：2020-02-05

  The present invention relates to a S1PR4-targeting composition for preventing or treating non-alcoholic steatohepatitis and, more particularly, to a pharmaceutical composition and a health functional food composition, both comprising a sphingolipid compound which serves as a functional inhibitor against S1PR4, showing prophylaxis and therapy of non-alcoholic steatohepatitis. The sphingolipid compound of the present invention is expected to be applied as a leading material effective for the prevention or treatment of non-alcoholic steatohepatitis (NASH) as it has the effect of reducing the infiltration of inflammatory cells into hepatic tissues and suppressing fibrosis and decreases a level of liver injury (ALT), inflammation in hepatic tissues, the expression of a fibrosis-related gene.

  本发明涉及一种用于预防或治疗非酒精性脂肪性肝炎的S1PR4靶向组合物，更具体地说，涉及一种药物组合物和一种保健功能食品组合物，二者均包含一种作为S1PR4功能抑制剂的鞘脂化合物，用于非酒精性脂肪性肝炎的预防和治疗。本发明的鞘脂化合物具有减少肝组织炎症细胞浸润、抑制肝纤维化、降低肝损伤（ALT）水平、肝组织炎症、纤维化相关基因表达的作用，因此有望作为有效预防或治疗非酒精性脂肪性肝炎（NASH）的主要材料应用。
• ZUSAMMENSETZUNGEN UMFASSEND MINDESTENS EIN POLYMER UND MINDESTENS EIN SALZ SOWIE ELEKTROLUMINESZENZVORRICHTUNGEN ENTHALTEND DIESE ZUSAMMENSETZUNGEN
  申请人：Merck Patent GmbH

  公开号：EP3241250B1

  公开（公告）日：2022-01-05
• US4026925A
  申请人：——

  公开号：US4026925A

  公开（公告）日：1977-05-31