tert-butyl N-[(1R,2R)-1,2-bis[4-[[3,5-bis(phenylmethoxy)phenyl]methoxy]phenyl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]ethyl]carbamate | 1436431-43-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: tert-butyl N-[(1R,2R)-1,2-bis[4-[[3,5-bis(phenylmethoxy)phenyl]methoxy]phenyl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]ethyl]carbamate
• CAS: 1436431-43-4
• 化学式: C₆₆H₆₈N₂O₁₀
• 分子量: 1049.27
• InChiKey: ALVFVAYPAWSHEM-VOVXCRLKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.5
• 重原子数：
  78
• 可旋转键数：
  27
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  132
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  tert-butyl N-[(1R,2R)-1,2-bis[4-[[3,5-bis(phenylmethoxy)phenyl]methoxy]phenyl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]ethyl]carbamate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 以86%的产率得到(1R,2R)-1,2-Bis-[4-(3,5-bis-benzyloxy-benzyloxy)-phenyl]-ethane-1,2-diamine
  参考文献：
  名称：

  Dendritic [RuCl2(BINAP)(DPEN)] catalysts with ‘Sandwich’ multi-layer structure for asymmetric hydrogenation of simple aryl ketones

  摘要：

  A new kind of chiral dendritic [RuCl2(BINAP)(DPEN)] catalysts with a 'Sandwich' multi-layer structure have been synthesized via metal coordination reactions with dendritic chiral diphosphines and dendritic chiral diamine ligands. The formation of the dendritic catalysts was confirmed by P-31 NMR. The catalyst performance was then investigated in the asymmetric hydrogenation of simple aryl ketones, and comparable enantioselectivities were achieved with comparison to that of the corresponding small-molecular catalyst. In addition, the recyclable property of these homogeneous catalysts was studied with the third-generation catalyst, which was reused nine times by simple solvent precipitation without any loss of enantioselectivity. (C) 2013 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2013.05.035
• 作为产物：
  描述：

  4-[(1R,2R)-1,2-diamino-2-(4-hydroxyphenyl)ethyl]phenol 在 potassium carbonate 、 potassium iodide 、 sodium hydroxide 作用下， 以 丙酮 为溶剂， 反应 24.0h， 生成 tert-butyl N-[(1R,2R)-1,2-bis[4-[[3,5-bis(phenylmethoxy)phenyl]methoxy]phenyl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]ethyl]carbamate
  参考文献：
  名称：

  Dendritic [RuCl2(BINAP)(DPEN)] catalysts with ‘Sandwich’ multi-layer structure for asymmetric hydrogenation of simple aryl ketones

  摘要：

  A new kind of chiral dendritic [RuCl2(BINAP)(DPEN)] catalysts with a 'Sandwich' multi-layer structure have been synthesized via metal coordination reactions with dendritic chiral diphosphines and dendritic chiral diamine ligands. The formation of the dendritic catalysts was confirmed by P-31 NMR. The catalyst performance was then investigated in the asymmetric hydrogenation of simple aryl ketones, and comparable enantioselectivities were achieved with comparison to that of the corresponding small-molecular catalyst. In addition, the recyclable property of these homogeneous catalysts was studied with the third-generation catalyst, which was reused nine times by simple solvent precipitation without any loss of enantioselectivity. (C) 2013 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2013.05.035