1-乙酰基-4-甲氧基-2-咪唑烷酮 | 320778-06-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 中文名称: 1-乙酰基-4-甲氧基-2-咪唑烷酮
• 英文名称: 1-Acetyl-4-methoxyimidazolidin-2-one
• CAS: 320778-06-1
• 化学式: C₆H₁₀N₂O₃
• 分子量: 158.157
• InChiKey: SGTUUGOLBDNFJK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-乙酰基-4-甲氧基-2-咪唑烷酮 、 alkaline earth salt of/the/ methylsulfuric acid 在 三氟化硼乙醚 、 lithium chloride 作用下， 以 四氢呋喃 为溶剂， 以61%的产率得到
  参考文献：
  名称：

  An unusual enhancement of chiral induction by chiral 2-imidazolidinone auxiliaries

  摘要：

  Diastereoselectivity which is induced by the use of 2-imidazolidinone auxiliaries is greatly dependent on the N-substituents of the heterocycles, among which the bulky arenesulfonyl group is the moiety of choice. Reactions of this type afford an excellent level of diastereoselection in the methylation of N'-butyryl-2-imidazolidinones via the metal enolates. (C) 2000 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(00)01547-1
• 作为产物：
  描述：

  甲醇 、 N-乙酰基-2-咪唑烷酮 生成 1-乙酰基-4-甲氧基-2-咪唑烷酮
  参考文献：
  名称：

  An unusual enhancement of chiral induction by chiral 2-imidazolidinone auxiliaries

  摘要：

  Diastereoselectivity which is induced by the use of 2-imidazolidinone auxiliaries is greatly dependent on the N-substituents of the heterocycles, among which the bulky arenesulfonyl group is the moiety of choice. Reactions of this type afford an excellent level of diastereoselection in the methylation of N'-butyryl-2-imidazolidinones via the metal enolates. (C) 2000 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(00)01547-1

文献信息

• An unusual enhancement of chiral induction by chiral 2-imidazolidinone auxiliaries
  作者：Alaa A.-M Abdel-Aziz、Junko Okuno、Shinsuke Tanaka、Tadao Ishizuka、Hirofumi Matsunaga、Takehisa Kunieda

  DOI：10.1016/s0040-4039(00)01547-1

  日期：2000.10

  Diastereoselectivity which is induced by the use of 2-imidazolidinone auxiliaries is greatly dependent on the N-substituents of the heterocycles, among which the bulky arenesulfonyl group is the moiety of choice. Reactions of this type afford an excellent level of diastereoselection in the methylation of N'-butyryl-2-imidazolidinones via the metal enolates. (C) 2000 Published by Elsevier Science Ltd.