7-methoxy-1-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-naphthalen-2-one | 1213262-08-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 7-methoxy-1-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-naphthalen-2-one
• CAS: 1213262-08-8
• 化学式: C₁₈H₁₅F₃O₂
• 分子量: 320.311
• InChiKey: CFTWPPSXHWOKFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  7-methoxy-1-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-naphthalen-2-one 在 sodium hydroxide 作用下， 以 甲醇 、 水 、 甲苯 为溶剂， 反应 13.0h， 生成 2-[7-Methoxy-1-[4-(trifluoromethyl)phenyl]-3,4-dihydronaphthalen-2-yl]acetic acid
  参考文献：
  名称：

  Photochromic 2h-chromenes annelated at c5-c6 and their methods of preparation

  摘要：

  本文描述了至少具有一个吸电子基团的C5-C6环化萘并吡喃。这些化合物具有诸如增加的褪色动力学等理想特性。本文还描述了合成C5-C6环化的2H-色苷的新方法。这些方法涉及较宽松的反应条件，并提供增加的反应产率。这些方法允许合成各种取代萘并吡喃，这些化合物可能对温度敏感，而以前的合成途径无法实现。

  公开号：

  EP2786991A3

文献信息

• 2H-CHROMENES ANNELATED AT C5-C6 AND METHODS OF MAKING AND USING THEREOF
  申请人：Das Suresh

  公开号：US20100056810A1

  公开（公告）日：2010-03-04

  Described herein are C 5 -C 6 annelated naphthopyrans that possess at least one electron-withdrawing group. The compounds possess desirable properties such as increased fading kinetics. Also described herein are new methods for synthesizing 2H-chromenes annelated at C 5 -C 6 . The methods involve less stringent reaction conditions as well as provide increased reaction yields. The methods permit the synthesis of a wide variety of substituted naphthopyrans that can be temperature sensitive, which was not possible with previous synthetic routes.

  本文描述了至少具有一个吸电子基团的C5-C6环联萘并吡喃骈。这些化合物具有增加的褪色动力学等理想特性。本文还描述了在C5-C6位置上环联的2H-色酮的新合成方法。这些方法涉及较宽松的反应条件，并提供增加的反应产率。这些方法允许合成各种取代的环联萘并吡喃骈，这些化合物可能对温度敏感，而以前的合成途径无法实现。
• EP2344469B1
  申请人：——

  公开号：EP2344469B1

  公开（公告）日：2014-05-07
• US8217188B2
  申请人：——

  公开号：US8217188B2

  公开（公告）日：2012-07-10
• [EN] PHOTOCHROMIC 2H-CHR0MENES ANNELATED AT C5-C6 AND THEIR METHODS OF PREPARATION<br/>[FR] 2H-CHROMÈNES PHOTOCHROMIQUES CONDENSÉS EN C5-C6 ET LEURS PROCÉDÉS DE PRÉPARATION
  申请人：CORNING INC

  公开号：WO2010027418A1

  公开（公告）日：2010-03-11

  Described herein are C5-C6 annelated naphthopyrans that possess at least one electron-withdrawing group. The compounds possess desirable properties such as increased fading kinetics. Also described herein are new methods for synthesizing 2H- chromenes annelated at C5-C6. The methods involve less stringent reaction conditions as well as provide increased reaction yields. The methods permit the synthesis of a wide variety of substituted naphthopyrans that can be temperature sensitive, which was not possible with previous synthetic routes.
• Photochromic 2h-chromenes annelated at c5-c6 and their methods of preparation
  申请人：Corning Incorporated

  公开号：EP2786991A3

  公开（公告）日：2014-11-12

  Described herein are C5-C6 annelated naphthopyrans that possess at least one electron-withdrawing group. The compounds possess desirable properties such as increased fading kinetics. Also described herein are new methods for synthesizing 2H-chromenes annelated at C5-C6. The methods involve less stringent reaction conditions as well as provide increased reaction yields. The methods permit the synthesis of a wide variety of substituted naphthopyrans that can be temperature sensitive, which was not possible with previous synthetic routes.

  本文描述了至少具有一个吸电子基团的C5-C6环化萘并吡喃。这些化合物具有诸如增加的褪色动力学等理想特性。本文还描述了合成C5-C6环化的2H-色苷的新方法。这些方法涉及较宽松的反应条件，并提供增加的反应产率。这些方法允许合成各种取代萘并吡喃，这些化合物可能对温度敏感，而以前的合成途径无法实现。