1-(Hydroxylamino)adamantane hydrochloride | 28547-72-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-(Hydroxylamino)adamantane hydrochloride
• 英文别名: N-adamantan-1-yl-hydroxylamine; hydrochloride；1-Hydroxylamino-adamantan-hydrochlorid；N-(1-adamantyl)hydroxylamine;hydrochloride
• CAS: 28547-72-0
• 化学式: C₁₀H₁₇NO*ClH
• 分子量: 203.712
• InChiKey: MPFITNXVGYAZQA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.36
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.3
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  聚合甲醛 、 1-(Hydroxylamino)adamantane hydrochloride 在 potassium carbonate 作用下， 生成 N,N'-di-adamantan-1-yl-N,N'-methanediyl-bis-hydroxylamine
  参考文献：
  名称：

  Die Reaktion von NN'-Dihydroxyaminalen mit Isocyansäureestern Mitt。超羟胺衍生物

  摘要：

  Die Einwirkung von 2 Mol Isocyansäureester auf 9 verschiedene NN'-Dihydroxyaminale (1) wird untersucht。Sie führt unter N→O-Umlagerung zu 3, oder unter Spaltung der Molekel zu den carbamoylierten Hydroxylaminen 5 und 6, oder zum 2.4-disubst。1,2.4-Oxadiazolidon-(5) 4 als Cycloadditionsprodukt des Isocyansäureesters mit einem bei der Spaltung intermediär gebildeten Formaldehydnitron 8。

  DOI：

  10.1002/ardp.19713041202

文献信息

• NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVE HAVING 11 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORY ACTIVITY
  申请人：Shionogi & Co., Ltd.

  公开号：EP2163543B1

  公开（公告）日：2015-03-04
• Zinner; Ruthe; Bose, Pharmazie, 1974, vol. 29, # 1, p. 16 - 20
  作者：Zinner、Ruthe、Bose

  DOI：——

  日期：——
• GRIGAT HARTMUT; ZINNER GERWALT, ARCH. PHARM., 319,(1986) N 11, 1037-1043
  作者：GRIGAT HARTMUT、 ZINNER GERWALT

  DOI：——

  日期：——
• NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVE HAVING 11SS-HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORY ACTIVITY
  申请人：Masuda Koji

  公开号：US20100240659A1

  公开（公告）日：2010-09-23

  Disclosed is a compound which is useful as an 11β-hydroxysteroid dehydrogenase type 1 inhibitor. A compound represented by the formula: , its pharmaceutically acceptable salt, or a solvate thereof, wherein Ring A is a group represented by the formula: Ring B is optionally substituted heteroaryl, provided that optionally substituted isoxazole is excluded, or optionally substituted heterocycle, R 1 is hydrogen or optionally substituted alkyl, R 2 is —OR 5 , —SR 5 , halogen, halogenated alkyl or the like, R 3 is optionally substituted alkyl or the like, R 4 is optionally substituted alkyl or the like, R 5 is optionally substituted alkyl or the like, R 6 is hydrogen or the like, R 7 and R 8 are each independently hydrogen or the like, R 10 and R 11 are each independently hydrogen or the like, R 12 is optionally substituted alkyl or the like, m and p are each independently integer of 1 to 3.
• US8383622B2
  申请人：——

  公开号：US8383622B2

  公开（公告）日：2013-02-26