N-(2-hydroxy-1,2-diphenyloct-3-ynyl)-4-methylbenzenesulfonamide | 959429-17-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: N-(2-hydroxy-1,2-diphenyloct-3-ynyl)-4-methylbenzenesulfonamide
• CAS: 959429-17-5
• 化学式: C₂₇H₂₉NO₃S
• 分子量: 447.598
• InChiKey: LAYKYRUOXDIWHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  74.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(2-hydroxy-1,2-diphenyloct-3-ynyl)-4-methylbenzenesulfonamide 在 碘 、 potassium carbonate 作用下， 以 二氯甲烷 为溶剂， 反应 16.0h， 以80%的产率得到5-butyl-4-iodo-1-(4-methylphenyl)sulfonyl-2,3-diphenyl-2H-pyrrol-3-ol
  参考文献：
  名称：

  A general approach to polysubstituted pyrroles

  摘要：

  Exposure of a range of 3-hydroxy-2-sulfonylamino-4-alkynes to excess iodine delivers good yields of a series of iodopyrroles. Unexpectedly, the hydroxyl-dihydropyrroles, which were assumed to be the first-formed intermediates, turn out to be stable entities which have been isolated for the first time. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.08.097
• 作为产物：
  描述：

  4-methyl-N-(2-oxo-1,2-diphenylethyl)benzene sulfonamide 、 1-己炔 在 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 反应 17.0h， 生成 N-(2-hydroxy-1,2-diphenyloct-3-ynyl)-4-methylbenzenesulfonamide
  参考文献：
  名称：

  A general approach to polysubstituted pyrroles

  摘要：

  Exposure of a range of 3-hydroxy-2-sulfonylamino-4-alkynes to excess iodine delivers good yields of a series of iodopyrroles. Unexpectedly, the hydroxyl-dihydropyrroles, which were assumed to be the first-formed intermediates, turn out to be stable entities which have been isolated for the first time. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.08.097

文献信息

• A general approach to polysubstituted pyrroles
  作者：David W. Knight、Heinz C. Rost、Christopher M. Sharland、Jirada Singkhonrat

  DOI：10.1016/j.tetlet.2007.08.097

  日期：2007.10

  Exposure of a range of 3-hydroxy-2-sulfonylamino-4-alkynes to excess iodine delivers good yields of a series of iodopyrroles. Unexpectedly, the hydroxyl-dihydropyrroles, which were assumed to be the first-formed intermediates, turn out to be stable entities which have been isolated for the first time. (C) 2007 Elsevier Ltd. All rights reserved.