N-methyl-N-ethoxyurethane | 67548-98-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-methyl-N-ethoxyurethane
• 英文别名: ethoxy-methyl-carbamic acid ethyl ester；N-Methyl-O-aethyl-N-carbaethoxy-hydroxylamin；Aethoxy-methyl-carbamidsaeure-aethylester；N-Aethoxy-N-methyl-urethan；ethyl N-ethoxy-N-methylcarbamate
• CAS: 67548-98-5
• 化学式: C₆H₁₃NO₃
• 分子量: 147.174
• InChiKey: VJXNRWJRKPCHBX-UHFFFAOYSA-N

物化性质

• 沸点：
  166-167 °C
• 密度：
  1.017±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-methyl-N-ethoxyurethane 在 盐酸 作用下， 以78%的产率得到N-methyl-O-ethylhydroxylamine hydrochloride
  参考文献：
  名称：

  Inglesi; Nicola; Magnetti, Il Farmaco, 1990, vol. 45, # 12, p. 1327 - 1340

  摘要：

  DOI：
• 作为产物：
  描述：

  溴乙烷 、 N-羟基-N-甲基氨基甲酸乙酯 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以52%的产率得到N-methyl-N-ethoxyurethane
  参考文献：
  名称：

  Inglesi; Nicola; Magnetti, Il Farmaco, 1990, vol. 45, # 12, p. 1327 - 1340

  摘要：

  DOI：

文献信息

• ABC TRANSPORTER INHIBITOR
  申请人：SUNTORY LIMITED

  公开号：EP1721901A1

  公开（公告）日：2006-11-15

  It is an object of the present invention to provide an ABC transporter inhibitor whereby the multi-drug resistance against anticancer drugs caused by amplification and expression of MDR1 gene, which is the most serious problem in chemotherapy for cancer, or the resistance against antifungal agents in mycotic diseases can be overcome. The present invention relates to an ABC transporter inhibitor containing enniatin or its analog as the active ingredient. The ABC transporter inhibitor of the present invention, being capable of inhibiting transport/excretion of a drug, especially an anticancer drug or an antifungal agent, from inside to outside of cells, is useful in preventing, suppressing, or inhibiting acquisition of resistance against various drugs.

  本发明的目的是提供一种 ABC 转运体抑制剂，从而克服因 MDR1 基因的扩增和表达而引起的对抗癌药物的多重耐药性（这是癌症化疗中最严重的问题）或霉菌病中对抗真菌药物的耐药性。本发明涉及一种以烯啶或其类似物为活性成分的 ABC 转运体抑制剂。本发明的ABC转运体抑制剂能够抑制药物，特别是抗癌药物或抗真菌药物从细胞内向细胞外的转运/排泄，因此可用于预防、抑制或抑制获得对各种药物的抗药性。
• Jones, American Chemical Journal, 1907, vol. 38, p. 257
  作者：Jones

  DOI：——

  日期：——
• INGLESI, MARCO;NICOLA, MASSIMO;MAGNETTI, SILVANO, FARMACO, 45,(1990) N2, C. 1327-1340
  作者：INGLESI, MARCO、NICOLA, MASSIMO、MAGNETTI, SILVANO

  DOI：——

  日期：——
• SUBSTITUIERTE (THIOXO)CARBONYLAMINOPHENYL-URACILE
  申请人：Bayer CropScience AG

  公开号：EP1503994A1

  公开（公告）日：2005-02-09
• Abc Transporter Inhibitor
  申请人：Oda Kohei

  公开号：US20080167444A1

  公开（公告）日：2008-07-10

  It is an object of the present invention to provide an ABC transporter inhibitor whereby the multi-drug resistance against anticancer drugs caused by amplification and expression of MDR1 gene, which is the most serious problem in chemotherapy for cancer, or the resistance against antifungal agents in mycotic diseases can be overcome. The present invention relates to an ABC transporter inhibitor containing enniatin or its analog as the active ingredient. The ABC transporter inhibitor of the present invention, being capable of inhibiting transport/excretion of a drug, especially an anticancer drug or an antifungal agent, from inside to outside of cells, is useful in preventing, suppressing, or inhibiting acquisition of resistance against various drugs.