(3R)-4-[tert-butyl(diphenyl)silyl]oxy-3-triethylsilyloxybutanal | 201936-27-8

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: (3R)-4-[tert-butyl(diphenyl)silyl]oxy-3-triethylsilyloxybutanal
• CAS: 201936-27-8
• 化学式: C₂₆H₄₀O₃Si₂
• 分子量: 456.773
• InChiKey: ZDQITCINKXADSL-HSZRJFAPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.54
• 重原子数：
  31
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (3R)-4-[tert-butyl(diphenyl)silyl]oxy-3-triethylsilyloxybutanal 在 偶氮二甲酸二异丙酯 、 potassium carbonate 、 对甲苯磺酸 、 三苯基膦 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 methyl 2-[(2S,4R,6R)-6-[[tert-butyl(diphenyl)silyl]oxymethyl]-4-hydroxy-2-methoxyoxan-2-yl]acetate
  参考文献：
  名称：

  Convergent synthesis of the C31C46 domain of the phorboxazole natural products

  摘要：

  A convergent synthesis of the C31-C46 domain of the phorboxazole natural products has been developed. This involved the preparation of a C39-C46 dienyl iodide and a C31-C37 aldehyde, followed by their CrCl2-mediated coupling and final installation of the C46 (E)-vinyl bromide via an alkyne hydrostannation-bromination sequence. (C) 1997 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(97)10519-6
• 作为产物：
  描述：

  methyl (3R)-4-(tert-butyldiphenylsilyloxy)-3-hydroxybutanoate 在 咪唑 、 二异丁基氢化铝 作用下， 生成 (3R)-4-[tert-butyl(diphenyl)silyl]oxy-3-triethylsilyloxybutanal
  参考文献：
  名称：

  Convergent synthesis of the C31C46 domain of the phorboxazole natural products

  摘要：

  A convergent synthesis of the C31-C46 domain of the phorboxazole natural products has been developed. This involved the preparation of a C39-C46 dienyl iodide and a C31-C37 aldehyde, followed by their CrCl2-mediated coupling and final installation of the C46 (E)-vinyl bromide via an alkyne hydrostannation-bromination sequence. (C) 1997 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(97)10519-6

文献信息

• Convergent synthesis of the C31C46 domain of the phorboxazole natural products
  作者：Feryan Ahmed、Craig J Forsyth

  DOI：10.1016/s0040-4039(97)10519-6

  日期：1998.1

  A convergent synthesis of the C31-C46 domain of the phorboxazole natural products has been developed. This involved the preparation of a C39-C46 dienyl iodide and a C31-C37 aldehyde, followed by their CrCl2-mediated coupling and final installation of the C46 (E)-vinyl bromide via an alkyne hydrostannation-bromination sequence. (C) 1997 Elsevier Science Ltd. All rights reserved.