1-amino-3-[(2S)-ethylpiperidin-1-yl]-propan-(2S)-ol | 558479-18-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-amino-3-[(2S)-ethylpiperidin-1-yl]-propan-(2S)-ol
• 英文别名: (S)-1-Amino-3-((S)-2-ethylpiperidin-1-yl)-propan-2-ol；(2S)-1-amino-3-[(2S)-2-ethylpiperidin-1-yl]propan-2-ol
• CAS: 558479-18-8
• 化学式: C₁₀H₂₂N₂O
• 分子量: 186.297
• InChiKey: SOVNLXOKUKWUOS-UWVGGRQHSA-N

物化性质

• 沸点：
  293.7±7.0 °C(Predicted)
• 密度：
  0.976±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  49.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-amino-3-[(2S)-ethylpiperidin-1-yl]-propan-(2S)-ol 、 1-萘磺酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 naphthalene-1-sulfonic acid [(R)-3-((S)-2-ethylpiperidin-1-yl)-2-hydroxypropyl]amide
  参考文献：
  名称：

  1,3-Diaminopropan-2-ol Sulfonamides as potent and selective inhibitors of the glycine transporter type 1

  摘要：

  High throughput screening led to the discovery of a novel series of 1,3-diaminopropan-2-ol sulfonarnides as selective GlyT-1 inhibitors. Structure-activity relationships of this novel series and optimisation of the initial hit that led to the identification of (2), a potent and selective GlyT-1 inhibitor, are also presented. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.12.063
• 作为产物：
  描述：

  (S)-2-乙基哌啶 在 palladium dihydroxide 叠氮化锂 、 氢气 、 potassium hydride 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 1-amino-3-[(2S)-ethylpiperidin-1-yl]-propan-(2S)-ol
  参考文献：
  名称：

  1,3-Diaminopropan-2-ol Sulfonamides as potent and selective inhibitors of the glycine transporter type 1

  摘要：

  High throughput screening led to the discovery of a novel series of 1,3-diaminopropan-2-ol sulfonarnides as selective GlyT-1 inhibitors. Structure-activity relationships of this novel series and optimisation of the initial hit that led to the identification of (2), a potent and selective GlyT-1 inhibitor, are also presented. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.12.063

文献信息

• Gly1 transporter inhibitors and uses thereof in treatment of neurological and neuropsychiatric disorders
  申请人：Bloomfield Jonathon Nic

  公开号：US20050267152A1

  公开（公告）日：2005-12-01

  The present invention relates to glycine transporter inhibiting compounds of formula (I): for treating disorders mediated by GlyT1, wherein R 1 —R 9 are as in the description.

  本发明涉及公式（I）的甘氨酸转运抑制化合物，用于治疗由GlyT1介导的疾病，其中R1-R9如描述。
• GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS
  申请人：SMITHKLINE BEECHAM PLC

  公开号：EP1455777A1

  公开（公告）日：2004-09-15
• HtrA Inhibitors and CagA Inhibitors and Use Thereof
  申请人：PSOMAGEN INC.

  公开号：US20220122691A1

  公开（公告）日：2022-04-21

  The present application relates to new HtrA inhibitors and use thereof. Additionally, the present application also relates to new peptides for inhibiting CagA and use thereof.
• [EN] GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS<br/>[FR] INHIBITEURS DE TRANSPORTEURS GLYT1 ET UTILISATONS DE CEUX-CI DANS LE TRAITEMENT DE TROUBLES NEUROLOGIQUES ET NEUROPSYCHIATRIQUES
  申请人：SMITHKLINE BEECHAM PLC

  公开号：WO2003055478A1

  公开（公告）日：2003-07-10

  The present invention relates to glycine transporter inhibiting compounds of formula (I): for the manufacture of a medicament for treating disorders mediated GlyT1, wherein R1-R9 are as in the description.
• 1,3-Diaminopropan-2-ol Sulfonamides as potent and selective inhibitors of the glycine transporter type 1
  作者：Shahzad S. Rahman、Steven Coulton、Hugh J. Herdon、Graham F. Joiner、Jian Jin、Roderick A. Porter

  DOI：10.1016/j.bmcl.2006.12.063

  日期：2007.3

  High throughput screening led to the discovery of a novel series of 1,3-diaminopropan-2-ol sulfonarnides as selective GlyT-1 inhibitors. Structure-activity relationships of this novel series and optimisation of the initial hit that led to the identification of (2), a potent and selective GlyT-1 inhibitor, are also presented. (c) 2007 Elsevier Ltd. All rights reserved.