5-Isopropylamino-6,7,8,9-tetrahydro-5H-benzocyclohepten | 17910-31-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 5-Isopropylamino-6,7,8,9-tetrahydro-5H-benzocyclohepten
• 英文别名: N-(Propan-2-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-amine；N-propan-2-yl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-amine
• CAS: 17910-31-5
• 化学式: C₁₄H₂₁N
• mdl: MFCD11139175
• 分子量: 203.327
• InChiKey: JLBNXFMTKAQNKC-UHFFFAOYSA-N

物化性质

• 沸点：
  306.4±21.0 °C(Predicted)
• 密度：
  0.96±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.571
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  benzosuberone oxime 在 乙醇 、 sodium 作用下， 以 甲苯 为溶剂， 生成 5-Isopropylamino-6,7,8,9-tetrahydro-5H-benzocyclohepten
  参考文献：
  名称：

  Khanna,J.M. et al., Indian Journal of Chemistry, 1967, vol. 5, p. 347 - 352

  摘要：

  DOI：

文献信息

• Metalloprotease inhibitors
  申请人：Sucholeiki Irving

  公开号：US20080021024A1

  公开（公告）日：2008-01-24

  The present invention relates to amide containing aromatic MMP inhibiting compounds with a mono-amide heteroaromatic group, of formulas I and II:

  本发明涉及具有含芳香族MMP抑制化合物的酰胺，其具有单酰胺杂芳基团，化学式I和II：
• Heterobicyclic metalloprotease inhibitors
  申请人：Gallagher M. Brian

  公开号：US20070155737A1

  公开（公告）日：2007-07-05

  The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic ADAMTS-4 inhibiting compounds.

  本发明通常涉及含有酰胺基团的药物，特别是含有酰胺基团的杂双环金属蛋白酶抑制剂化合物。更具体地，本发明提供了一类新的杂双环ADAMTS-4抑制剂化合物。
• Heterobicyclic Metalloprotease Inhibitors
  申请人：STEENECK Christoph

  公开号：US20090312312A1

  公开（公告）日：2009-12-17

  The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting and MMP-3 inhibiting compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.
• HETEROBICYCLIC METALLOPROTEASE INHIBITORS
  申请人：Steeneck Christoph

  公开号：US20120015920A1

  公开（公告）日：2012-01-19

  The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting and MMP-3 inhibiting compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.
• US7795245B2
  申请人：——

  公开号：US7795245B2

  公开（公告）日：2010-09-14