3-methyl-naphthalene-1,8-dicarboxylic acid anhydride | 17190-45-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-methyl-naphthalene-1,8-dicarboxylic acid anhydride
• 英文别名: 3-Methyl-naphthalin-1,8-dicarbonsaeure-anhydrid；3-methyl-1,8-naphthalic anhydride；3-methyl-1,8-naphtalic anhydride；7-Methyl-3-oxatricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaene-2,4-dione
• CAS: 17190-45-3
• 化学式: C₁₃H₈O₃
• 分子量: 212.205
• InChiKey: ZONYNOMFWDCKNH-UHFFFAOYSA-N

物化性质

• 熔点：
  242.5-243.5 °C
• 沸点：
  432.2±24.0 °C(Predicted)
• 密度：
  1.387±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-methyl-naphthalene-1,8-dicarboxylic acid anhydride 在 lithium aluminium tetrahydride 、 乙醚 、 苯 作用下， 生成 1,8-bis-hydroxymethyl-3-methyl-naphthalene
  参考文献：
  名称：

  A STUDY OF THE METHYLATION AND TAUTOMERISM OF 8-METHYLPERINAPHTHENE

  摘要：

  DOI：

  10.1021/jo01369a015
• 作为产物：
  描述：

  2-methyl-1H-phenalene 在 potassium permanganate 、 丙酮 作用下， 生成 3-methyl-naphthalene-1,8-dicarboxylic acid anhydride
  参考文献：
  名称：

  A STUDY OF THE METHYLATION AND TAUTOMERISM OF 8-METHYLPERINAPHTHENE

  摘要：

  DOI：

  10.1021/jo01369a015

文献信息

• Isoquinolones
  申请人：Warner-Lambert Company

  公开号：US06177423B1

  公开（公告）日：2001-01-23

  Benzo[de]isoquinoline-1,3-dione of Formula or a pharmaceutically acceptable salt thereof wherein R is hydrogen or a protecting group typically used in the art for protecting alcohols and R1-R5 are each independently chosen from H, Cl, Br, F, straight or branched alkyl C1-C8 alkyl, C3-C8 cycloalkyl, heterocycle or bridged heterocycle of 4-9 atoms containing 1-3 heteroatoms, —(CR′2)nOR6, —(CR′2)nN(R6)2, —(CR′2)nNR6COR7, —(CR′2)nNR6SO2OR7, —(CR′2)nNR6SO2 N(R6)2, —(CR′2)nOSO2 N(R6)2, —(CR′2)nCN, —(CR′2)n(NOR6)R7, NO2, CF3, —(CR′2)nSOmR7, —(CR′2)nSOmR7, —(CR′2)nCO2R6, —(CR′2)nCON(R6)2, Ph, and any two of R1-R5 may form a substituted or unsubstituted ring of 5-7 total atoms having 0-2 heteroatoms are claimed which are selective inhibitors of bacterial DNA gyrase and DNA topoisomerase useful in antibacterial agents. Methods for their preparation and formulation as well as novel intermediates useful in the preparation of the final products are also claimed.

  苯并[de]异喹啉-1,3-二酮的化学式，或其在药学上可接受的盐，其中R为氢或通常用于保护醇的艺术中的保护基，R1-R5分别独立地选择自H、Cl、Br、F、直链或支链烷基C1-C8烷基、C3-C8环烷基、杂环或含有1-3个杂原子的4-9个原子的桥接杂环，—(CR′2)nOR6、—(CR′2)nN(R6)2、—(CR′2)nNR6COR7、—(CR′2)nNR6SO2OR7、—(CR′2)nNR6SO2 N(R6)2、—(CR′2)nOSO2 N(R6)2、—(CR′2)nCN、—(CR′2)n(NOR6)R7、NO2、CF3、—(CR′2)nSOmR7、—(CR′2)nSOmR7、—(CR′2)nCO2R6、—(CR′2)nCON(R6)2、Ph，以及R1-R5中的任意两个可形成具有0-2个杂原子的5-7个总原子的取代或未取代环的选择性细菌DNA旋转酶和DNA拓扑异构酶抑制剂，适用于抗菌剂。还声明了它们的制备和配方方法，以及在制备最终产品中有用的新型中间体。
• 2-heteroaryl-alkyl-1H-benz[de]-isoquinoline-1,3(2H)-diones
  申请人：American Cyanamid Co.

  公开号：US04782064A1

  公开（公告）日：1988-11-01

  This invention concerns novel 2-heteroarylalkyl-1H-benz[de]isoquinoline-1,3(2H)-diones which are useful as inhibitors of thromboxane synthetase and/or as hypotensive agents in the treatment of hypertension and myocardial ischemia.

  这项发明涉及新型的2-杂环芳基烷基-1H-苯并[de]异喹啉-1,3(2H)-二酮，可用作抑制血栓素合酶和/或作为治疗高血压和心肌缺血的降压剂。
• N-OXY-NAPHTHALIMIDES AS ANTIBACTERIAL AGENTS
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0939754A2

  公开（公告）日：1999-09-08
• SULFONIC ACID DERIVATIVE COMPOUND, PHOTOACID GENERATOR, RESIST COMPOSITION, CATIONIC POLYMERIZATION INITIATOR, AND CATIONICALLY POLYMERIZABLE COMPOSITION
  申请人：ADEKA CORPORATION

  公开号：US20180079724A1

  公开（公告）日：2018-03-22

  Provide are: a sulfonic acid derivative compound which has high absorbance for light having a wavelength of 365 nm and exhibits high solubility in organic solvents and good acid generation rate; a photoacid generator; a resist composition; a cationic polymerization initiator; and a cationically polymerizable composition. The sulfonic acid derivative compound is represented by the following Formula (I): (wherein, X represents a linear or branched alkyl group having 1 to 14 carbon atoms; and R represents an aliphatic hydrocarbon group having 1 to 18 carbon atoms, an aryl group having 6 to 20 carbon atoms, an arylalkyl group having 7 to 20 carbon atoms, an acyl group-substituted aryl group having 7 to 20 carbon atoms, an alicyclic hydrocarbon group having 3 to 12 carbon atoms, a 10-camphoryl group or the like).
• US4782064A
  申请人：——

  公开号：US4782064A

  公开（公告）日：1988-11-01