methyl 3-(3-oxo-1H-pyrrolo[3,4-c]pyridin-2-yl)propanoate | 1006878-87-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡啶类
• 英文名称: methyl 3-(3-oxo-1H-pyrrolo[3,4-c]pyridin-2-yl)propanoate
• CAS: 1006878-87-0
• 化学式: C₁₁H₁₂N₂O₃
• 分子量: 220.228
• InChiKey: XJIYOGMUFBURPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  59.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  piperidin-1-yl(pyridin-3-yl)methanone 、 Methyl 3-[(cyanomethyl)amino]propanoate 在 2,2,6,6-四甲基哌啶 、 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 以28%的产率得到methyl 3-(3-oxo-1H-pyrrolo[3,4-c]pyridin-2-yl)propanoate
  参考文献：
  名称：

  Aminomethylation of lithiated nicotinamide: access to new pyridolactams

  摘要：

  New 2,3-dihydropyrrolopyridinones were conveniently prepared by trapping lithiated pyridine carboxamides, with highly reactive formimines. In this Letter, we report that a wide range of N-functionalised compounds can be synthesised in one step by this process, allowing the presence of ethers, acetals or ester moieties. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.11.109

文献信息

• Aminomethylation of lithiated nicotinamide: access to new pyridolactams
  作者：Emilie Prieur、Rabah Azzouz、Geoffrey Deguest、Corinne Fruit、Laurent Bischoff、Francis Marsais

  DOI：10.1016/j.tetlet.2007.11.109

  日期：2008.1

  New 2,3-dihydropyrrolopyridinones were conveniently prepared by trapping lithiated pyridine carboxamides, with highly reactive formimines. In this Letter, we report that a wide range of N-functionalised compounds can be synthesised in one step by this process, allowing the presence of ethers, acetals or ester moieties. (C) 2007 Elsevier Ltd. All rights reserved.