2-[4-(2-fluoro-phenyl)-piperazin-1-yl]-N-(3-nitro-phenyl)-acetamide | 329059-07-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-[4-(2-fluoro-phenyl)-piperazin-1-yl]-N-(3-nitro-phenyl)-acetamide
• 英文别名: 2-[4-(2-fluorophenyl)piperazin-1-yl]-N-(3-nitrophenyl)acetamide
• CAS: 329059-07-6
• 化学式: C₁₈H₁₉FN₄O₃
• 分子量: 358.372
• InChiKey: HZXWIUKBVNWHOE-UHFFFAOYSA-N

物化性质

• 沸点：
  555.4±50.0 °C(Predicted)
• 密度：
  1.340±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  81.4
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-[4-(2-fluoro-phenyl)-piperazin-1-yl]-N-(3-nitro-phenyl)-acetamide 在 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以67%的产率得到N-(3-amino-phenyl)-2-[4-(2-fluoro-phenyl)-piperazin-1-yl]-acetamide
  参考文献：
  名称：

  Benzamide derivatives as dual-action hypoglycemic agents that inhibit glycogen phosphorylase and activate glucokinase

  摘要：

  A series of benzamide derivatives which can simultaneously inhibit glycogen phosphorylase (GP) and activate glucokinase (GK) were prepared and evaluated. The structure-activity relationships (SAR) of these compounds were also presented. Among these, compounds 12, 13l, 13q, and 13v showed moderate activities towards both GK and GP. Compound 13h inhibited hLGP with an IC50 of 8.95 mu M and activated GK with an EC50 of 1.87 mu M. The possible binding modes of compounds 12, 13l, 13h, and 13q with GP and GK were also explored by molecular docking simulation. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.08.045
• 作为产物：
  描述：

  1-(2-氟苯基)哌嗪 、 N-氯乙酰-3-硝基苯胺 在 potassium carbonate 、 potassium iodide 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 生成 2-[4-(2-fluoro-phenyl)-piperazin-1-yl]-N-(3-nitro-phenyl)-acetamide
  参考文献：
  名称：

  Benzamide derivatives as dual-action hypoglycemic agents that inhibit glycogen phosphorylase and activate glucokinase

  摘要：

  A series of benzamide derivatives which can simultaneously inhibit glycogen phosphorylase (GP) and activate glucokinase (GK) were prepared and evaluated. The structure-activity relationships (SAR) of these compounds were also presented. Among these, compounds 12, 13l, 13q, and 13v showed moderate activities towards both GK and GP. Compound 13h inhibited hLGP with an IC50 of 8.95 mu M and activated GK with an EC50 of 1.87 mu M. The possible binding modes of compounds 12, 13l, 13h, and 13q with GP and GK were also explored by molecular docking simulation. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.08.045

文献信息

• Benzamide derivatives as dual-action hypoglycemic agents that inhibit glycogen phosphorylase and activate glucokinase
  作者：Lei Zhang、Honglin Li、Qingzhang Zhu、Jun Liu、Ling Chen、Ying Leng、Hualiang Jiang、Hong Liu

  DOI：10.1016/j.bmc.2009.08.045

  日期：2009.10

  A series of benzamide derivatives which can simultaneously inhibit glycogen phosphorylase (GP) and activate glucokinase (GK) were prepared and evaluated. The structure-activity relationships (SAR) of these compounds were also presented. Among these, compounds 12, 13l, 13q, and 13v showed moderate activities towards both GK and GP. Compound 13h inhibited hLGP with an IC50 of 8.95 mu M and activated GK with an EC50 of 1.87 mu M. The possible binding modes of compounds 12, 13l, 13h, and 13q with GP and GK were also explored by molecular docking simulation. (C) 2009 Elsevier Ltd. All rights reserved.