5-Methyl-2-thiophenecarbaldehyde 1-phthalazinylhydrazone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 5-Methyl-2-thiophenecarbaldehyde 1-phthalazinylhydrazone
• 英文别名: N-[(E)-(5-methylthiophen-2-yl)methylideneamino]phthalazin-1-amine
• 化学式: C₁₄H₁₂N₄S
• 分子量: 268.342
• InChiKey: RWTOMRNSNXDPFA-CXUHLZMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  78.4
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  5-甲基-2-噻吩甲醛 、 1-hydrazinophthalazine 以 乙醇 为溶剂， 生成 5-Methyl-2-thiophenecarbaldehyde 1-phthalazinylhydrazone
  参考文献：
  名称：

  New α-(N)-heterocyclichydrazones: evaluation of anticancer, anti-HIV and antimicrobial activity

  摘要：

  A series of 3- and 5-methylthiophene-2-carboxaldehyde alpha-(N)-heterocyclichydrazones were synthesized and submitted to an in vitro investigation of their anticancer, anti-HIV and antimicrobial activities. Some of the newly synthesized compounds were found to possess antiproliferative properties, whereas no anti-HIV activity was seen: the most active of the series was the derivative 2i, which exhibited turnout Growth inhibition activity against all cell lines displaying Gl(50) values between 1.63 and 26.5 muM. The title compounds were generally ineffective against Grain-positive and Gram-negative bacteria, while showed a moderate antifungal activity against C. albicans and A.fumigatus. (C) 2003 Elsevier SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2003.09.012

文献信息

• New α-(N)-heterocyclichydrazones: evaluation of anticancer, anti-HIV and antimicrobial activity
  作者：Luisa Savini、Luisa Chiasserini、Valter Travagli、Cesare Pellerano、Ettore Novellino、Sofia Cosentino、M.Barbara Pisano

  DOI：10.1016/j.ejmech.2003.09.012

  日期：2004.2

  A series of 3- and 5-methylthiophene-2-carboxaldehyde alpha-(N)-heterocyclichydrazones were synthesized and submitted to an in vitro investigation of their anticancer, anti-HIV and antimicrobial activities. Some of the newly synthesized compounds were found to possess antiproliferative properties, whereas no anti-HIV activity was seen: the most active of the series was the derivative 2i, which exhibited turnout Growth inhibition activity against all cell lines displaying Gl(50) values between 1.63 and 26.5 muM. The title compounds were generally ineffective against Grain-positive and Gram-negative bacteria, while showed a moderate antifungal activity against C. albicans and A.fumigatus. (C) 2003 Elsevier SAS. All rights reserved.