Tert-butyl[(16-iodohexadecyl)oxy]dimethylsilane | 824404-37-7

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: Tert-butyl[(16-iodohexadecyl)oxy]dimethylsilane
• 英文别名: tert-butyl-(16-iodohexadecoxy)-dimethylsilane
• CAS: 824404-37-7
• 化学式: C₂₂H₄₇IOSi
• 分子量: 482.605
• InChiKey: PMXUBDFRNQUSGN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.9
• 重原子数：
  25
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  Tert-butyl[(16-iodohexadecyl)oxy]dimethylsilane 在 正丁基锂 、 三乙胺 、 mercury dichloride 、 mercury(II) oxide 作用下， 以 四氢呋喃 为溶剂， 生成 (E)-19-(tert-Butyl-dimethyl-silanyloxy)-1-(2,6,6-trimethyl-cyclohex-1-enyl)-nonadec-1-en-3-one
  参考文献：
  名称：

  Probes which reflect the distance between the retinal chromophore and membrane surface in bacteriorhodopsin (bR). Direction of retinal 9-methyl in bR

  摘要：

  DOI：

  10.1021/ja00195a073
• 作为产物：
  描述：

  氧杂环十七烷-2-酮 在 咪唑 、 lithium aluminium tetrahydride 、 氢碘酸 作用下， 以 四氢呋喃 、 二氯甲烷 、 甲苯 为溶剂， 反应 24.0h， 生成 Tert-butyl[(16-iodohexadecyl)oxy]dimethylsilane
  参考文献：
  名称：

  Tocopherol long chain fatty alcohols decrease the production of TNF-α and NO radicals by activated microglial cells

  摘要：

  The synthesis of a series of Tocopherol long chain Fatty Alcohols (TEA) and their biological activities on the modulation of microglial activation are described. Specifically, the 2-(12-hydroxy-dodecyl)-2,5,7,8-tetramethyl-chroman-6-ol, the TEA bearing 12 carbon atoms on the side chain (n = 12), shows the most potent inhibition of secretion on nitric oxide (NO) and tumour necrosis factor-alpha (TNF-alpha) by lipopolysaccharide (LPS)-activated microglia. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.09.078

文献信息

• Synthetic Studies on Kohamaic Acids: Synthesis of Structurally Simplified Analogs of Kohamaic Acid A
  作者：Hirosato TAKIKAWA、Naoki KAMATANI、Kohei NAKANISHI、Takuya TASHIRO、Mitsuru SASAKI、Hiromi YOSHIDA、Yoshiyuki MIZUSHINA

  DOI：10.1271/bbb.80629

  日期：2008.11.23

  Kohamaic acid A is a potent DNA polymerase inhibitor isolated from the Okinawan marine sponge Ircinia sp. A series of structurally simplified analogs of kohamaic acid A were synthesized with the aim of evaluating structure-activity relationships.

  Kohamaic acid A是一种有效的DNA聚合酶抑制剂，是从冲绳海洋海绵Ircinia sp。中分离得到的。为了评估结构-活性关系，合成了一系列结构简化的kohamaic acid A类似物。
• Synthesis of tritium labeled KRN7000
  作者：Martijn D.P. Risseeuw、Celia R. Berkers、Hidde L. Ploegh、Huib Ovaa

  DOI：10.1016/j.tetlet.2006.03.131

  日期：2006.5

  The synthesis of a multiple tritiated analog of KRN7000 (α-galactosyl ceramide) is described, enabling further studies to quantitate the affinity of KRN7000 for its receptor and to study its pharmacokinetic properties.

  描述了KRN7000（α-半乳糖基神经酰胺）的多个tri代类似物的合成，从而使进一步的研究能够定量KRN7000与其受体的亲和力，并研究其药代动力学特性。
• Tocopherol long chain fatty alcohols decrease the production of TNF-α and NO radicals by activated microglial cells
  作者：Thierry Muller、Luc Grandbarbe、Eleonora Morga、Paul Heuschling、Bang Luu

  DOI：10.1016/j.bmcl.2004.09.078

  日期：2004.12

  The synthesis of a series of Tocopherol long chain Fatty Alcohols (TEA) and their biological activities on the modulation of microglial activation are described. Specifically, the 2-(12-hydroxy-dodecyl)-2,5,7,8-tetramethyl-chroman-6-ol, the TEA bearing 12 carbon atoms on the side chain (n = 12), shows the most potent inhibition of secretion on nitric oxide (NO) and tumour necrosis factor-alpha (TNF-alpha) by lipopolysaccharide (LPS)-activated microglia. (C) 2004 Elsevier Ltd. All rights reserved.
• Probes which reflect the distance between the retinal chromophore and membrane surface in bacteriorhodopsin (bR). Direction of retinal 9-methyl in bR
  作者：Myung Hwan Park、Toshihiro Yamamoto、Koji Nakanishi

  DOI：10.1021/ja00195a073

  日期：1989.6