1-acetyl-4-(3-chloro-phenyl)-piperazine | 141511-13-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-acetyl-4-(3-chloro-phenyl)-piperazine
• 英文别名: 1-Acetyl-4-(3-chlor-phenyl)-piperazin；1-[4-(3-Chlorophenyl)piperazin-1-yl]ethan-1-one；1-[4-(3-chlorophenyl)piperazin-1-yl]ethanone
• CAS: 141511-13-9
• 化学式: C₁₂H₁₅ClN₂O
• mdl: MFCD01195289
• 分子量: 238.717
• InChiKey: FGZISPCFLHSBOQ-UHFFFAOYSA-N

物化性质

• 沸点：
  418.8±40.0 °C(Predicted)
• 密度：
  1.218±0.06 g/cm3(Predicted)
• 保留指数：
  2265;2265

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.416
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-氯苯胺 生成 1-acetyl-4-(3-chloro-phenyl)-piperazine
  参考文献：
  名称：

  Derivatives of Piperazine. XXIV. Synthesis of 1-Arylpiperazines and Amino Alcohol Derivatives

  摘要：

  DOI：

  10.1021/ja01636a034

文献信息

• Novel Tetracyclic Tetrahydrofuran Derivatives Containing Cyclic Amine Side Chain
  申请人：Cid-Nunez Jose Maria

  公开号：US20080262076A1

  公开（公告）日：2008-10-23

  This invention concerns novel substituted tetracyclic tetrahydrofuran derivatives containing a cyclic amine side chain with binding affinities towards dopamine receptors, in particular dopamine D 2 receptors, towards serotonin receptors, in particular 5-HT 2A and 5-HT 2C receptors, and pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic, cardiovascular and gastrokinetic disorders and processes for their production. The compounds according to the invention can be represented by general Formula (I) and comprises also a pharmaceutically acceptable acid or base addition salt thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, wherein all substituents are defined as in Claim 1.

  本发明涉及一种新型取代四环四氢呋喃衍生物，其含有一个环状胺侧链，具有结合多巴胺受体的亲和力，特别是多巴胺D2受体，对5-HT2A和5-HT2C受体的亲和力，以及包含根据本发明的化合物的制药组合物，其用作药物，特别是用于预防和/或治疗一系列精神和神经疾病，特别是某些精神病、心血管和胃动力紊乱，并提供其生产过程。根据本发明的化合物可以用一般式（I）表示，并包括其药学上可接受的酸或碱盐、N-氧化物形式或季铵盐，其中所有取代基在权利要求书1中定义。
• Khadilkar B. M., Sarrant S. D., Indian J. Chem. B, 32 (1993) N 11, S 1137-1142
  作者：Khadilkar B. M., Sarrant S. D.

  DOI：——

  日期：——
• COMPOUNDS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASE
  申请人：Shy Therapeutics LLC

  公开号：EP3394056B1

  公开（公告）日：2021-04-14
• SEPIAPTERIN REDUCTASE INHIBITORS
  申请人：QUARTET MEDICINE, INC.

  公开号：US20170096435A1

  公开（公告）日：2017-04-06

  Inhibitors of sepiapterin reductase and uses of sepiapterin reductase inhibitors in analgesia, treatment of acute and chronic pain, anti-inflammation, and immune cell regulation are disclosed.
• 5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS
  申请人：GALAPAGOS NV

  公开号：US20210309614A1

  公开（公告）日：2021-10-07

  The present invention discloses compounds according to Formula I: Wherein R 1 , R 2 , R 3a , R 3b , and Cy are as defined herein. The present invention relates to compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory conditions, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis by administering a compound of the invention.