3'R,4'R-dihydroxy-3,2',2'-trimethylpyrano[2,3-f]chromone | 743435-46-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 3'R,4'R-dihydroxy-3,2',2'-trimethylpyrano[2,3-f]chromone
• 英文别名: (9R,10R)-9,10-dihydroxy-3,8,8-trimethyl-9,10-dihydropyrano[2,3-f]chromen-4-one
• CAS: 743435-46-3
• 化学式: C₁₅H₁₆O₅
• 分子量: 276.289
• InChiKey: QHAYLEITZRJHGS-TZMCWYRMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (1S)-(-)-莰烷酰氯 、 3'R,4'R-dihydroxy-3,2',2'-trimethylpyrano[2,3-f]chromone 在 4-二甲氨基吡啶 作用下， 以 二氯甲烷 为溶剂， 以75%的产率得到3'R,4'R-di-O-(-)-camphanoyl-3,2',2'-trimethyldihydropyrano[2,3-f]chromone
  参考文献：
  名称：

  Anti-AIDS agents 79. Design, synthesis, molecular modeling and structure–activity relationships of novel dicamphanoyl-2′,2′-dimethyldihydropyranochromone (DCP) analogs as potent anti-HIV agents

  摘要：

  In a continued study, 23 3'R,4'R-di-O-(-)-camphanoyl-2',2'-dimethyldihydropyrano[2,3-f]chromone (DCP) derivatives (5-27) were synthesized, and screened for anti-HIV activity against both a non-drug-resistant NL4-3 strain and multiple reverse transcriptase (RT) inhibitor-resistant (RTMDR-1) strain, using 2-EDCP (4) and 2-MDCP (35) as controls. New DCP analogs 5, 9, 14, and 22 exhibited potent anti-HIV activity against HIV(NL4-3) with EC(50) and therapeutic index (TI) values ranging from 0.036 mu M to 0.14 mu M and from 110 to 420, respectively. Compounds 5 and 9 also exhibited good activity against RTMDR-1 (EC(50) 0.049 and 0.054 mu M; TI 310 and 200, respectively), and were twofold more potent than the leads 4 and 35 (EC(50) 0.11 and 0.19 mu M; TI 60 and 58, respectively). Evaluation of water solubility showed that 5 and 22 were 5-10 times more water soluble than 4. Quantitative structure-activity relationship (QSAR) modeling results were first performed on this compound type, and the models should aid in design of future anti-HIV DCP analogs and potential clinical drug candidates. (c) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.07.065
• 作为产物：
  描述：

  7-(1,1-Dimethyl-prop-2-ynyloxy)-3-methyl-chromen-4-one 在 potassium dioxotetrahydroxoosmate(VI) 、 甲基磺酰胺 (DHQ)2-PHAL 、 potassium carbonate 、 N,N-二乙基苯胺 、 potassium hexacyanoferrate(III) 作用下， 以 叔丁醇 为溶剂， 生成 3'R,4'R-dihydroxy-3,2',2'-trimethylpyrano[2,3-f]chromone
  参考文献：
  名称：

  抗艾滋病剂。60.取代的3′R，4′R-二-O-（-）-樟脑酰基-2′，2′-二甲基二氢吡喃并[2，3-f]色酮（DCP）类似物作为有效的抗HIV剂。

  摘要：

  位置异构体的合成是药物设计中常用的技术。因此，根据先前对3'R，4'R-di-O-（S）-樟脑酰基-（+）-顺式-甲壳酮（DCK，1）类似物的SAR研究，一系列的单或双取代色酮衍生物设计并合成了3'R，4'R-di-O-（-）-樟脑酰基-2'，2'-二甲基二氢吡喃并[2,3-f]色酮（DCP，4）。连同1和4-甲基DCK（2）一起，对所有新合成的DCP类似物（4-21）筛选针对H9淋巴细胞中的非耐药菌株和多重逆转录酶（RT）的抗HIV-1活性。 MT4细胞系中具有抗抑制剂作用的菌株。几种DCP类似物（4、5、7、8、13和17）在非耐药菌株测定中显示出极高的抗HIV活性，EC（50）值在0.00032至0之间。0057 microM和显着的治疗指数（TI）从5.6 x 10（3）到1.16 x 10（5），与2的相似（EC（50）0.0059 microM，TI> 6.6 x 10（3））和优于1（EC（50）0

  DOI：

  10.1021/jm0400505

文献信息

• Anti-AIDS Agents. 60. Substituted 3‘<i>R</i>,4‘<i>R</i>-Di-<i>O</i>-(−)-camphanoyl-2‘,2‘-dimethyldihydropyrano[2,3-<i>f</i>]chromone (DCP) Analogues as Potent Anti-HIV Agents
  作者：Donglei Yu、Chin-Ho Chen、Arnold Brossi、Kuo-Hsiung Lee

  DOI：10.1021/jm0400505

  日期：2004.7.1

  Synthesis of positional isomers is a commonly used technique in drug design. Accordingly, based on prior SAR studies of 3'R,4'R-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK, 1) analogues, a series of mono- and disubstituted chromone derivatives of 3'R,4'R-di-O-(-)-camphanoyl-2',2'-dimethyldihydropyrano[2,3-f]chromone (DCP, 4) were designed and synthesized. Together with 1 and 4-methyl DCK (2), all

  位置异构体的合成是药物设计中常用的技术。因此，根据先前对3'R，4'R-di-O-（S）-樟脑酰基-（+）-顺式-甲壳酮（DCK，1）类似物的SAR研究，一系列的单或双取代色酮衍生物设计并合成了3'R，4'R-di-O-（-）-樟脑酰基-2'，2'-二甲基二氢吡喃并[2,3-f]色酮（DCP，4）。连同1和4-甲基DCK（2）一起，对所有新合成的DCP类似物（4-21）筛选针对H9淋巴细胞中的非耐药菌株和多重逆转录酶（RT）的抗HIV-1活性。 MT4细胞系中具有抗抑制剂作用的菌株。几种DCP类似物（4、5、7、8、13和17）在非耐药菌株测定中显示出极高的抗HIV活性，EC（50）值在0.00032至0之间。0057 microM和显着的治疗指数（TI）从5.6 x 10（3）到1.16 x 10（5），与2的相似（EC（50）0.0059 microM，TI> 6.6 x 10（3））和优于1（EC（50）0
• Anti-AIDS agents 79. Design, synthesis, molecular modeling and structure–activity relationships of novel dicamphanoyl-2′,2′-dimethyldihydropyranochromone (DCP) analogs as potent anti-HIV agents
  作者：Ting Zhou、Qian Shi、Chin-Ho Chen、Hao Zhu、Li Huang、Phong Ho、Kuo-Hsiung Lee

  DOI：10.1016/j.bmc.2010.07.065

  日期：2010.9

  In a continued study, 23 3'R,4'R-di-O-(-)-camphanoyl-2',2'-dimethyldihydropyrano[2,3-f]chromone (DCP) derivatives (5-27) were synthesized, and screened for anti-HIV activity against both a non-drug-resistant NL4-3 strain and multiple reverse transcriptase (RT) inhibitor-resistant (RTMDR-1) strain, using 2-EDCP (4) and 2-MDCP (35) as controls. New DCP analogs 5, 9, 14, and 22 exhibited potent anti-HIV activity against HIV(NL4-3) with EC(50) and therapeutic index (TI) values ranging from 0.036 mu M to 0.14 mu M and from 110 to 420, respectively. Compounds 5 and 9 also exhibited good activity against RTMDR-1 (EC(50) 0.049 and 0.054 mu M; TI 310 and 200, respectively), and were twofold more potent than the leads 4 and 35 (EC(50) 0.11 and 0.19 mu M; TI 60 and 58, respectively). Evaluation of water solubility showed that 5 and 22 were 5-10 times more water soluble than 4. Quantitative structure-activity relationship (QSAR) modeling results were first performed on this compound type, and the models should aid in design of future anti-HIV DCP analogs and potential clinical drug candidates. (c) 2010 Elsevier Ltd. All rights reserved.