4-(4-bromo-2-fluoroanilino)-6-methoxy-7-hydroxyquinazoline trifluoroacetate | 932016-08-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-hydroxyquinazoline trifluoroacetate
• 英文别名: 7-hydroxy-4-(4-bromo-2-fluoroanilino)-6-methoxyquinazoline trifluoroacetate；4-(4-Bromo-2-fluorophenylamino)-6-methoxyquinazolin-7-ol tfa salt；4-(4-bromo-2-fluoroanilino)-6-methoxyquinazolin-7-ol;2,2,2-trifluoroacetic acid
• CAS: 932016-08-5
• 化学式: C₂HF₃O₂*C₁₅H₁₁BrFN₃O₂
• 分子量: 478.198
• InChiKey: VJLQGSMITWJOIC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.62
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  105
• 氢给体数：
  3
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  4-(4-bromo-2-fluoroanilino)-6-methoxy-7-hydroxyquinazoline trifluoroacetate 、 3-氰基苄基溴 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 2.0h， 以40%的产率得到4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(3-cyanobenzyloxy)quinazoline
  参考文献：
  名称：

  QUINAZOLINE DERIVATIVE

  摘要：

  公开号：

  EP3181554B1
• 作为产物：
  描述：

  4-溴-2-氟苯胺 、 三氟乙酸 在 氢氧化钾 、 水 作用下， 以 甲苯 为溶剂， 反应 11.5h， 生成 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-hydroxyquinazoline trifluoroacetate
  参考文献：
  名称：

  WO2007/36713

  摘要：

  公开号：

文献信息

• CHEMICAL PROCESS
  申请人：BLIXT Jorgen

  公开号：US20120095229A1

  公开（公告）日：2012-04-19

  The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilising said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline.

  本发明涉及用于制造某些喹噁啉衍生物或其药学上可接受的盐的化学过程。本发明还涉及用于制造制造喹噁啉衍生物的某些中间体的过程，以及利用该中间体制造喹噁啉衍生物的过程。特别地，本发明涉及用于制造化合物4-(4-溴-2-氟苯氨基)-6-甲氧基-7-(1-甲基哌啶-4-基甲氧基)喹噁啉的化学过程和中间体。
• Chemical Process for the Synthesis of 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline
  申请人：Astrazeneca AB

  公开号：US20140378684A1

  公开（公告）日：2014-12-25

  The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilising said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline.

  本发明涉及用于制造某些喹唑啉衍生物或其药学上可接受的盐的化学过程。本发明还涉及用于制造喹唑啉衍生物的某些中间体的过程，以及利用这些中间体制造喹唑啉衍生物的过程。特别是，本发明涉及用于制造化合物4-（4-溴-2-氟苯胺基）-6-甲氧基-7-（1-甲基哌啶-4-基甲氧基）喹唑啉的化学过程和中间体。
• Chemical in situ sulphonating process
  申请人：AstraZeneca AB

  公开号：EP2053048A1

  公开（公告）日：2009-04-29

  The present invention relates to chemical processes for the manufacture of certain intermediates useful in the manufacture of certain quinazoline derivatives. In particular, the present invention relates to chemical processes for the manufacture of certain intermediates useful in the manufacture of the compound 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline.

  本发明涉及用于制造某些喹唑啉衍生物的某些中间体的化学工艺。特别是，本发明涉及制造某些用于制造化合物 4-(4-溴-2-氟苯胺基)-6-甲氧基-7-(1-甲基哌啶-4-基甲氧基)喹唑啉的中间体的化学工艺。
• Chemical process for the synthesis of 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline
  申请人：Genzyme Corporation

  公开号：US10344015B2

  公开（公告）日：2019-07-09

  The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilizing said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline.

  本发明涉及制造某些喹唑啉衍生物或其药学上可接受的盐的化学工艺。本发明还涉及用于制造喹唑啉衍生物的某些中间体的制造工艺，以及利用上述中间体制造喹唑啉衍生物的工艺。本发明尤其涉及用于制造化合物 4-(4-溴-2-氟苯胺基)-6-甲氧基-7-(1-甲基哌啶-4-基甲氧基)喹唑啉的化学工艺和中间体。
• Quinazoline derivative
  申请人：CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD.

  公开号：US10421754B2

  公开（公告）日：2019-09-24

  Provided are a quinazoline derivative, a pharmaceutical composition containing the same, a method for preparation of said derivative, and an application of same as an anti-cancer drug.

  本文提供了一种喹唑啉衍生物、一种含有该衍生物的药物组合物、一种制备该衍生物的方法以及该衍生物作为抗癌药物的应用。