diethyl 2-propionylindolizin-7-ylphosphonate | 1448604-38-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡啶类
• 英文名称: diethyl 2-propionylindolizin-7-ylphosphonate
• 英文别名: 1-(7-Diethoxyphosphorylindolizin-2-yl)propan-1-one；1-(7-diethoxyphosphorylindolizin-2-yl)propan-1-one
• CAS: 1448604-38-3
• 化学式: C₁₅H₂₀NO₄P
• 分子量: 309.302
• InChiKey: IQVWPYQNTPUMKB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  57
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  烯丙基磷酸二乙酯 在 溴 、 sodium hydride 、 potassium carbonate 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 35.0h， 生成 diethyl 2-propionylindolizin-7-ylphosphonate
  参考文献：
  名称：

  Synthesis of Nitrogen Bridgehead Heterocycles with Phosphonates via a Novel Tandem Process

  摘要：

  A novel and efficient method was developed for the synthesis of nitrogen bridgehead heterocycles with phosphonates. Nitrogen containing five-membered heterocyclic aldehyde and diethyl 3-bromoprop-1-enylphosphonate were used as substrates. Bridgehead nitrogen-containing arylphosphonates were obtained via one-pot reaction including four steps: S(N)2, deprotonation followed by electron flow, nucleophic additon and elimination of water.

  DOI：

  10.3987/com-12-12661

文献信息

• Synthesis of Nitrogen Bridgehead Heterocycles with Phosphonates via a Novel Tandem Process
  作者：Jian-Wu Wang、Jiong Jia、Ya-Fei Xie、Lei Feng、Hua-Qiang Xu、Song Meng、Gui-Long Zhao、Wei-Ren Xu、Yan-Qing Ge

  DOI：10.3987/com-12-12661

  日期：——

  A novel and efficient method was developed for the synthesis of nitrogen bridgehead heterocycles with phosphonates. Nitrogen containing five-membered heterocyclic aldehyde and diethyl 3-bromoprop-1-enylphosphonate were used as substrates. Bridgehead nitrogen-containing arylphosphonates were obtained via one-pot reaction including four steps: S(N)2, deprotonation followed by electron flow, nucleophic additon and elimination of water.