3-Cyclohexylamino-propylguanidin | 13860-67-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-Cyclohexylamino-propylguanidin
• 英文别名: 1-(3-(Cyclohexylamino)propyl)guanidine；2-[3-(cyclohexylamino)propyl]guanidine
• CAS: 13860-67-8
• 化学式: C₁₀H₂₂N₄
• 分子量: 198.311
• InChiKey: JFCBDCWYMZCHTF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  76.4
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  S-甲基异硫脲硫酸盐 、 N-(3-氨丙基)环己胺 以 水 为溶剂， 生成 3-Cyclohexylamino-propylguanidin
  参考文献：
  名称：

  Ueda,T.; Ishizaki,K., Chemical and pharmaceutical bulletin, 1967, vol. 15, p. 228 - 232

  摘要：

  DOI：

文献信息

• Lactam compounds useful as protein kinase inhibitors
  申请人：Blackburn Christopher

  公开号：US20090105213A1

  公开（公告）日：2009-04-23

  The present invention provides novel compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.

  本发明提供了一种新型化合物，可用作蛋白激酶的抑制剂。本发明还提供了包括本发明化合物的药物组合物以及使用该组合物治疗各种疾病的方法。
• LACTAM COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS
  申请人：Blackburn Christopher

  公开号：US20120178739A1

  公开（公告）日：2012-07-12

  The present invention provides novel compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.

  本发明提供了一种新型化合物，可用作蛋白激酶抑制剂。本发明还提供了包含所述化合物的药物组合物，以及使用该组合物治疗各种疾病的方法。
• Antimicrobial compounds and methods of making and using the same
  申请人：Melinta Therapeutics, Inc.

  公开号：US10259825B2

  公开（公告）日：2019-04-16

  The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and/or reducing the risk of microbial infections in humans and animals.

  本发明总体上涉及抗微生物化合物领域及其制造和使用方法。这些化合物可用于治疗、预防和/或降低人类和动物微生物感染的风险。
• ANTIMICROBIAL COMPOUNDS AND METHODS OF MAKING AND USING THE SAME
  申请人：Melinta Therapeutics, Inc.

  公开号：EP2488532B1

  公开（公告）日：2018-05-09
• Antimicrobial Compounds And Methods Of Making And Using The Same
  申请人：Melinta Therapeutics, Inc.

  公开号：US20170320892A1

  公开（公告）日：2017-11-09

  The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and/or reducing the risk of microbial infections in humans and animals.