N-[叔丁基(二苯基)甲硅烷基]-1-苯基甲胺 | 119645-09-9

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 中文名称: N-[叔丁基(二苯基)甲硅烷基]-1-苯基甲胺
• 英文名称: N-t-butyl-diphenylsilylbenzilamine
• 英文别名: N-(t-butyldiphenylsilyl)benzylamine；N-benzyl(tert-butyl)diphenylsilanamine；N-[(1,1-dimethylethyl)diphenylsilyl]benzenemethanamine；N-Benzyl-1-tert-butyl-1,1-diphenylsilanamine；N-[tert-butyl(diphenyl)silyl]-1-phenylmethanamine
• CAS: 119645-09-9
• 化学式: C₂₃H₂₇NSi
• 分子量: 345.56
• InChiKey: YDHKBFMZBFFPSS-UHFFFAOYSA-N

物化性质

• 熔点：
  32-34 °C
• 沸点：
  233 °C(Press: 0.5 Torr)
• 密度：
  1.03±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.34
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-[叔丁基(二苯基)甲硅烷基]-1-苯基甲胺 在 盐酸 作用下， 以 四氢呋喃 、 水 为溶剂， 生成 2-Aminomethyl-5-chlorbenzhydrol
  参考文献：
  名称：

  A novel rearrangement forming 4,5,6,11-tetra-hydrobenzo[6,7]cycloocta[1,2-b]thiophen-6,11-imines

  摘要：

  DOI：

  10.1016/s0040-4039(01)93742-6
• 作为产物：
  描述：

  叔丁基二苯基氯硅烷 、 苄胺 在 三乙胺 作用下， 以 乙腈 为溶剂， 以98%的产率得到N-[叔丁基(二苯基)甲硅烷基]-1-苯基甲胺
  参考文献：
  名称：

  N-Silyl Protecting Groups for Labile Aziridines:  Application toward the Synthesis of N-H Aziridinomitosenes

  摘要：

  Hindered N-silylarnines were examined for their utility to serve as protecting groups for the labile aziridine nitrogen found within the highly sensitive aziridinomitosene framework. tert-Butyldiphenylsilyl and modified tert-butyldiphenylsilyl groups were the most resistant to nitrogen- silicon bond cleavage under various reaction conditions and were thus employed in transformations relevant to aziridinomitosene synthesis. The N-silylaziridines 7a, 21a, and 21b underwent azomethine ylide cycloaddition and afforded, upon deprotection, the N-H aziridine 24 in 18-32% overall yield for the three steps.

  DOI：

  10.1021/jo7013615

文献信息

• 4,5,6,11-tetrahydrobenzo [6,7] cycloocta [1,2-b]thiophen-6,11-imines and
  申请人：Pfizer Inc.

  公开号：US05260309A1

  公开（公告）日：1993-11-09

  The present invention relates to compounds of the formula ##STR1## wherein the broken line represents a saturated or an olefinic bond, R.sup.1 and R.sup.4 are each hydrogen or C.sub.1 to C.sub.6 alkyl, and R.sup.2 and R.sup.3 are each hydrogen, C.sub.1 to C.sub.6 alkyl, halogen, C.sub.1 to C.sub.6 alkoxy or C.sub.1 to C.sub.6 alkylthio, and pharmaceutically acceptable salts thereof, pharmaceutical compounds containing the same, methods of preparing the foregoing compounds, and to novel intermediates in the preparation of the foregoing compounds. These compounds are useful as agents in the prevention of neuronal damage in the brain following cerebral ischemia and during the progression of Alzheimer's disease and also as anticonvulsants.

  本发明涉及式子##STR1##的化合物，其中断线表示饱和或烯烃键，R.sup.1和R.sup.4分别是氢或C.sub.1到C.sub.6烷基，R.sup.2和R.sup.3分别是氢，C.sub.1到C.sub.6烷基，卤素，C.sub.1到C.sub.6烷氧基或C.sub.1到C.sub.6烷基硫醚，以及其药学上可接受的盐，含有这些化合物的制药化合物，制备上述化合物的方法，以及制备上述化合物的新中间体。这些化合物可用作在脑缺血后预防神经元损伤以及在阿尔茨海默病进展期间和抗癫痫药物的代理。
• <i>N</i>-Silyloxaziridines: Synthesis and Use for Electrophilic Amination
  作者：Nicolas Richy、Mohammed Ghoraf、Joëlle Vidal

  DOI：10.1021/jo302182t

  日期：2012.12.7

  N-Silyloxaziridines were synthesized for the first time. Their tert-butyldiphenylsilyl (TBDPS) derivatives were stable reagents that were prepared on a multigram scale in three steps and in 44% overall yield from the corresponding benzylamines. They were mild electrophilic aminating reagents that reacted at room temperature with diversely substituted primary and secondary amines to produce N-monoalkyl or N,N-dialkyl benzaldehyde hydrazones in 44-87% yield.
• ROBINSON, RALPH P.;DONAHUE, KATHLEEN M.;SACCOMANO, NICHOLAS A., TETRAHEDRON LETT., 30,(1989) N9, C. 5203-5206
  作者：ROBINSON, RALPH P.、DONAHUE, KATHLEEN M.、SACCOMANO, NICHOLAS A.

  DOI：——

  日期：——
• ROBINSON, RALPH
  作者：ROBINSON, RALPH

  DOI：——

  日期：——
• ASAO, NAOKI;UYEHARA, TADAO;YAMAMOTO, YOSHINORI, TETRAHEDRON, 44,(1988) N 13, 4173-4180
  作者：ASAO, NAOKI、UYEHARA, TADAO、YAMAMOTO, YOSHINORI

  DOI：——

  日期：——