N-(4,4'-Dimethoxydiphenylmethyl)-3-oxo-4-azaandrost-5-ene-17β-carboxamide | 142140-44-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: N-(4,4'-Dimethoxydiphenylmethyl)-3-oxo-4-azaandrost-5-ene-17β-carboxamide
• 英文别名: (1S,3aS,3bS,9aR,9bS,11aS)-N-[bis(4-methoxyphenyl)methyl]-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,6,8,9,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide
• CAS: 142140-44-1
• 化学式: C₃₄H₄₂N₂O₄
• 分子量: 542.718
• InChiKey: RTDQSGGUFXOWKN-IQHRVDSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  40
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  76.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-氧代-4-氮杂-5-雄烷-17B-羧酸 以50%的产率得到N-(4,4'-Dimethoxydiphenylmethyl)-3-oxo-4-azaandrost-5-ene-17β-carboxamide
  参考文献：
  名称：

  Azasteroid compounds for the treatment of prostatic hypertrophy, their

  摘要：

  式(I)的化合物：##STR1##（其中：R.sup.1是氢原子、未取代的烷基基团、芳基取代的烷基基团或杂环取代的烷基基团；R.sup.2是芳基取代的烷基基团、杂环取代的烷基基团或二芳胺基团；R.sup.3是氢原子、未取代的烷基基团、芳基取代的烷基基团或具有3至6个碳原子的烯基基团；以及由.alpha.-.beta.和.gamma.-.delta.表示的键中的每一个是碳-碳单键或碳-碳双键；）及其药学上可接受的盐和酯对于前列腺肥大的治疗和预防是有用的。我们还提供它们的制备方法。

  公开号：

  US05302621A1

文献信息

• Azasteroid compounds for the treatment of prostatic hypertrophy, their preparation and use
  申请人：Sankyo Company Limited

  公开号：EP0484094A2

  公开（公告）日：1992-05-06

  Compounds of formula (I) : (in which : R1 is a hydrogen atom, an unsubstituted alkyl group, an aryl-substituted alkyl group or a heterocyclic-substituted alkyl group ; R2 is an aryl-substituted alkyl group, a heterocyclic-substituted alkyl group or a diarylamino group ; R3 is a hydrogen atom, an unsubstituted alkyl group, an aryl-substituted alkyl group or an alkenyl group having from 3 to 6 carbon atoms ; and each of the bonds represented by α-β and y-8 is a carbon-carbon single bond or a carbon-carbon double bond ;) and pharmaceutically acceptable salts and esters thereof are useful for the treatment and prophylaxis of prostatic hypertrophy. We also provide processes for their preparation.

  式(I)化合物 (其中：R1 是氢原子、未取代的烷基、芳基取代的烷基或杂环取代的烷基； R2 是芳基取代的烷基、杂环取代的烷基或二芳基氨基； R3 是氢原子、未取代的烷基、芳基取代的烷基或具有 3 至 6 个碳原子的烯基；α-β和y-8所代表的键中的每一个都是碳-碳单键或碳-碳双键；）及其药学上可接受的盐和酯可用于治疗和预防前列腺肥大。我们还提供了其制备工艺。
• US5302621A
  申请人：——

  公开号：US5302621A

  公开（公告）日：1994-04-12
• Azasteroid compounds for the treatment of prostatic hypertrophy, their
  申请人：Sankyo Company, Limited

  公开号：US05302621A1

  公开（公告）日：1994-04-12

  Compounds of formula (I): ##STR1## (in which: R.sup.1 is a hydrogen atom, an unsubstituted alkyl group, an aryl-substituted alkyl group or a heterocyclic-substituted alkyl group; R.sup.2 is an aryl-substituted alkyl group, a heterocyclic-substituted alkyl group or a diarylamino group; R.sup.3 is a hydrogen atom, an unsubstituted alkyl group, an aryl-substituted alkyl group or an alkenyl group having from 3 to 6 carbon atoms; and each of the bonds represented by .alpha.-.beta. and .gamma.-.delta. is a carbon-carbon single bond or a carbon-carbon double bond;) and pharmaceutically acceptable salts and esters thereof are useful for the treatment and prophylaxis of prostatic hypertrophy. We also provide processes for their preparation.

  式(I)的化合物：##STR1##（其中：R.sup.1是氢原子、未取代的烷基基团、芳基取代的烷基基团或杂环取代的烷基基团；R.sup.2是芳基取代的烷基基团、杂环取代的烷基基团或二芳胺基团；R.sup.3是氢原子、未取代的烷基基团、芳基取代的烷基基团或具有3至6个碳原子的烯基基团；以及由.alpha.-.beta.和.gamma.-.delta.表示的键中的每一个是碳-碳单键或碳-碳双键；）及其药学上可接受的盐和酯对于前列腺肥大的治疗和预防是有用的。我们还提供它们的制备方法。