N,N-dicyclohexylethylenediamine | 50331-65-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N-dicyclohexylethylenediamine
• 英文别名: 2-Dicyclohexylamino-aethylamin；N~1~,N~1~-dicyclohexyl-1,2-ethanediamine；N',N'-dicyclohexylethane-1,2-diamine
• CAS: 50331-65-2
• 化学式: C₁₄H₂₈N₂
• 分子量: 224.39
• InChiKey: MILHQHDXRQFQCW-UHFFFAOYSA-N

物化性质

• 沸点：
  148-154 °C(Press: 45 Torr)
• 密度：
  0.96±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  环氧乙烷 、 N,N-dicyclohexylethylenediamine 生成 N,N-Dicyclohexyl-N'-<2-hydroxy-aethyl>-aethylendiamin
  参考文献：
  名称：

  A New Method for the Preparation of Piperazines. I. Preparation ofN-Mono-alkyl(-aryl)-piperazines

  摘要：

  DOI：

  10.1246/bcsj.34.651
• 作为产物：
  描述：

  在 盐酸 作用下， 生成 N,N-dicyclohexylethylenediamine
  参考文献：
  名称：

  Phosphoramides ω aminès

  摘要：

  DOI：

  10.1016/s0022-328x(00)85441-8

文献信息

• [EN] A NOVEL POLYMORPHIC FORM OF ATORVASTATIN SALTS<br/>[FR] NOUVELLE FORME POLYMORPHE DE SELS D'ATORVASTATINE
  申请人：ORCHID CHEMICALS & PHARM LTD

  公开号：WO2011089559A1

  公开（公告）日：2011-07-28

  The present invention provides an improved process for the preparation of Atorvastatin of formula (I) or its salts, preferably hemicalcium salt with purity greater than 99.5% using novel salts of Atorvastatin such as N,N- dicyclohexylethylenediamine salt of Atorvastatin and novel polymorph of Atorvastatin sodium salt. Formula (I).

  本发明提供了一种改进的工艺，用于制备化学式（I）的阿托伐他汀或其盐，优选纯度大于99.5%的盐酸阿托伐他汀，使用阿托伐他汀的新型盐，如阿托伐他汀的N,N-二环己基乙二胺盐和阿托伐他汀钠盐的新型多晶形态。 化学式（I）。
• Novel transition metal complex and process for producing optically active alcohol
  申请人：Mikami Koichi

  公开号：US20060142603A1

  公开（公告）日：2006-06-29

  A novel transition metal complex, preferably a ruthenium-phosphine complex or rhodium-phosphine complex, which is effectively usable in various asymmetric syntheses and, in particular, is more effectively usable in the asymmetric hydrogenation of various ketones; and a novel process for producing an optically active alcohol with the complex. The novel transition metal complex includes a ligand obtained by introducing a diarylphosphino group into each of the 2- and 2′-positions of diphenyl ether, benzophenone, benzhydrol, or the like. It preferably further includes an optically active 1,2-diphenylethylenediamine coordinated thereto. The complex preferably is a novel diphosphine-ruthenium-optically active diamine complex or diphosphine-rhodium-optically active diamine complex. The process comprises using the complex as an asymmetric hydrogenation catalyst to conduct the asymmetric hydrogenation of a ketone compound to thereby obtain an optically active alcohol in a high optical purity and a high yield.

  一种新型的过渡金属配合物，优选为钌膦配合物或铑膦配合物，可有效用于各种不对称合成中，特别是在各种酮的不对称氢化反应中更有效地使用；以及一种使用该配合物生产光学活性醇的新工艺。该新型过渡金属配合物包括通过将二苯醚、苯甲酮、苯甲醇等化合物的2-和2'-位引入二芳基膦基团而获得的配体。它优选还包括一个光学活性的1,2-二苯乙二胺配位。该配合物优选为新型双膦钌-光学活性二胺配合物或新型双膦铑-光学活性二胺配合物。该工艺包括使用该配合物作为不对称氢化催化剂，进行酮化合物的不对称氢化反应，从而高效地获得光学纯度高、收率高的光学活性醇。
• Grafted viscosity index improver
  申请人：EXXON CHEMICAL PATENTS INC.

  公开号：EP0400867A1

  公开（公告）日：1990-12-05

  Oil soluble grafted ethylene-alpha-olefin copolymer useful as a viscosity modifier for oleaginous compositions comprising: (i) backbone copolymer of ethylene and at least one other alpha-olefin monomer, said copolymer comprising intramolecularly heterogeneous copolymer chains containing at least one crystallizable segment of methylene units and at least one low crystallinity ethylene-alpha-olefin copolymer segment, wherein said at least one crystallizable segment comprises at least about 10 weight percent of said copolymer chain and contains at least about 57 weight percent ethylene, wherein said low crystallinity segment contains not greater than about 53 weight percent ethylene, and wherein said copolymer has a molecular weight distribution characterized by at least one of a ratio of Mw/Mn of less than 2 and a ratio of Mz/M2 of less than 1.8, and wherein at least two portions of an individual intramolecularly heterogeneous chain, each portion comprising at least 5 weight percent of said chain, differ in composition from one another by at least 7 weight percent ethylene; having grafted on said backbone copolymer (ii) residue of ethylenically unsaturated grafting material; said grafted ethylenealpha-olefin copolymer having substantially the molecular weight distribution, i.e., within about 10 percent, of said copolymer of ethylene. The preferred grafting material is an ethylenically monounsaturated carboxylic acid material having 1 to 2 carboxylic acid groups or an anhydride group.

  可溶于油的接枝乙烯-α-烯烃共聚物，可用作含油组合物的粘度调节剂，其成分包括 (i) 乙烯和至少另一种α-烯烃单体的骨架共聚物，所述共聚物包括分子内异构共聚物链，其中至少含有一个亚甲基单元的可结晶段和至少一个低结晶度的乙烯-α-烯烃共聚物段、其中所述至少一个可结晶段占所述共聚物链的至少约 10 重量％，并含有至少约 57 重量％的乙烯，其中所述低结晶度段含有不大于约 53 重量％的乙烯，并且所述共聚物具有分子量分布，其特征为 Mw/Mn 比值小于 2 和 Mz/M2 比值小于 1 中的至少一种。8，且其中单个分子内异质链的至少两个部分（每个部分占所述链的至少 5 重量％）在组成上彼此相差至少 7 重量％的乙烯；在所述骨架共聚物上接枝有 (ii) 乙烯不饱和接枝材料的残留物；所述接枝的乙烯-α-烯烃共聚物的分子量分布与所述乙烯共聚物基本相同，即在约 10%以内。优选的接枝材料是具有 1 至 2 个羧酸基团或酸酐基团的乙烯单不饱和羧酸材料。
• Multifunctional viscosity index improver
  申请人：EXXON CHEMICAL PATENTS INC.

  公开号：EP0422858A2

  公开（公告）日：1991-04-17

  Composition of matter useful as a multifunctional viscosity index improver for lubricating oils comprising reaction product of: (i) (a) degraded ethylene-alpha-olefin copolymer obtained by degrading undegraded copolymer of ethylene and at least one other alpha-olefin monomer, said undegraded copolymer comprising intramolecularly heterogeneous copolymer chains containing at least one crystallizable segment of methylene units and at least one low crystallinity ethylene-alpha- olefin copolymer segment, wherein said at least one crystallizable segment comprises at least about 10 weight percent of said copolymer chain and contains at least about 57 weight percent of said copolymer chain and contains at least about 57 weight percent ethylene, wherein said low crystallinity segment contains not greater than about 53 weight percent ethylene, and wherein said copolymer has a molecular weight distribution characterized by at least one of a ratio of M w/M n of less than 2 and a ratio of M Z/M w of less than 1.8 and wherein at least two portions of an individual intramolecularly heterogeneous chain, each portion comrising at least 5 weight percent of said chain, differ in composition form one another by at least 7 weight percent ethylene; said degraded copolymer grafted with (b) ethylenically monounsaturated carboxylic acid material having 1 to 2 carboxylic acid groups or anhydride group to form grafted degraded ethylene copolymer; and (ii) at least one polyamine containing one primary amino group and at least one tertiary amino group.

  可用作润滑油多功能粘度指数改进剂的物质组合物，包括下列物质的反应产物 (i) (a) 降解乙烯-α-烯烃共聚物，该共聚物通过降解未降解的乙烯和至少另一种 α-烯烃单体共聚物而获得，所述未降解共聚物包含分子内异构共聚物链，其中 至少含有一个亚甲基单元可结晶段和至少一个低结晶度乙烯-α-烯烃共聚物段、其中所述至少一个可结晶段包含至少约 10 重量百分比的所述共聚物链，并且包含至少约 57 重量百分比的所述共聚物链，并且包含至少约 57 重量百分比的乙烯，其中所述低结晶度段包含不大于约 53 重量百分比的乙烯，并且所述共聚物具有分子量分布，其特征在于 M w/M n 的比率小于 2 和 M Z/M w 的比率小于 1 中的至少一个。(b) 具有 1 至 2 个羧酸基团或酸酐基团的乙烯基单不饱和羧酸材料接枝的降解共聚物，以形成接枝的降解乙烯共聚物；以及 (i) 具有 1 至 2 个羧酸基团或酸酐基团的乙烯基单不饱和羧酸材料接枝的降解共聚物。 (ii) 至少一种含有一个伯氨基和至少一个叔氨基的多胺。
• NOVEL TRANSITION METAL COMPLEX AND PROCESS FOR PRODUCING OPTICALLY ACTIVE ALCOHOL WITH THE COMPLEX
  申请人：Takasago International Corporation

  公开号：EP1661903A1

  公开（公告）日：2006-05-31

  A novel transition metal complex, preferably a ruthenium-phosphine complex or rhodium-phosphine complex, which is effectively usable in various asymmetric syntheses and, in particular, is more effectively usable in the asymmetric hydrogenation of various ketones; and a novel process for producing an optically active alcohol with the complex. The novel transition metal complex includes a ligand obtained by introducing a diarylphosphino group into each of the 2- and 2'-positions of diphenyl ether, benzophenone, benzhydrol, or the like. It preferably further includes an optically active 1,2-diphenylethylenediamine coordinated thereto. The complex preferably is a novel diphosphine-ruthenium-optically active diamine complex or diphosphine-rhodium-optically active diamine complex. The process comprises using the complex as an asymmetric hydrogenation catalyst to conduct the asymmetric hydrogenation of a ketone compound to thereby obtain an optically active alcohol in a high optical purity and a high yield.

  一种新型过渡金属络合物，最好是钌膦络合物或铑膦络合物，可有效地用于各种不对称合成，特别是可更有效地用于各种酮的不对称氢化；以及一种用该络合物生产光学活性醇的新型工艺。新型过渡金属配合物包括一种配体，该配体是通过在二苯醚、二苯甲酮、二苯甲醇或类似物的 2- 和 2'- 位上各引入一个二芳基膦基而得到的。它最好还包括与之配位的具有光学活性的 1,2-二苯基乙二胺。该配合物最好是新型二膦-钌-光学活性二胺配合物或二膦-铑-光学活性二胺配合物。该工艺包括使用该配合物作为不对称氢化催化剂，对酮化合物进行不对称氢化，从而以高光学纯度和高产率获得光学活性醇。