4,7-dichloro-3',6'-dihydroxy-spiro[phthalan-1,9'-xanthen]-3-one | 596-12-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 4,7-dichloro-3',6'-dihydroxy-spiro[phthalan-1,9'-xanthen]-3-one
• 英文别名: 4,7-Dichlor-3',6'-dihydroxy-spiro[phthalan-1,9'-xanthen]-3-on；4,7-dichloro-fluorescein；4,7-Dichloro-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one
• CAS: 596-12-3
• 化学式: C₂₀H₁₀Cl₂O₅
• 分子量: 401.202
• InChiKey: PJSUUEGBBMAVQU-UHFFFAOYSA-N

物化性质

• 沸点：
  690.0±55.0 °C(Predicted)
• 密度：
  1.75±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  27
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3,6-二氯邻苯二甲酸 反应 20.0h， 生成 4,7-dichloro-3',6'-dihydroxy-spiro[phthalan-1,9'-xanthen]-3-one
  参考文献：
  名称：

  Le Royer, Justus Liebigs Annalen der Chemie, 1887, vol. 238, p. 357

  摘要：

  DOI：

文献信息

• [EN] TETRACYCLIC INHIBITORS OF JANUS KINASES<br/>[FR] INHIBITEURS TETRACYCLIQUES DE JANUS KINASES
  申请人：INCYTE CORP

  公开号：WO2005105814A1

  公开（公告）日：2005-11-10

  The present invention provides compounds that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases and cancer.

  本发明提供了能调节雅努斯激酶活性并且在治疗与雅努斯激酶活性相关的疾病方面有用的化合物，例如免疫相关疾病和癌症。
• Fluorescent nucleobase conjugates having anionic linkers
  申请人：PE Corporation (NY)

  公开号：US20020102590A1

  公开（公告）日：2002-08-01

  Provided are nucleotide-dye conjugates and related compounds in which a dye is linked to a nucleobase directly or indirectly by an anionic linker. The anionic character of the linker is provided by one or more anionic moieties which are present in the linker, such as phosphate, phosphonate, sulfonate, and carboxylate groups. When the dye is a provided as a donor/acceptor dye pair, the anionic linker can be located between the donor and the acceptor, or between the nucleobase and either the donor or acceptor, or both. In one embodiment, conjugates of the invention provide enhanced electrophoretic mobility characteristics to sequencing fragments, e.g., for dideoxy sequencing using labeled terminators.

  提供了核苷酸染料共轭物和相关化合物，其中染料通过阴离子连接物直接或间接地与核碱基相连。连接物的阴离子性质由连接物中存在的一个或多个阴离子基团提供，例如磷酸酯基、膦酸酯基、磺酸基和羧酸基。当染料作为给体/受体染料对提供时，阴离子连接物可以位于给体和受体之间，或者位于核碱基和给体或受体之间，或两者之间。在一种实施方案中，本发明的共轭物提供了增强的电泳迁移特性，例如，用标记终止子进行二氧基测序的测序片段。
• Lipophilic electrophoretic probes
  申请人：——

  公开号：US20040022843A1

  公开（公告）日：2004-02-05

  Compounds, compositions, and methods for labeling membranes are disclosed. Compounds of formula G-L-E are described wherein G is a lipophilic group, L is a cleavable linkage and E is an electrophoretic group. The compounds become associated with membranes, and can be cleaved with a cleavage-inducing moiety thereby releasing the detectable electrophoretic group.

  本发明公开了用于标记膜的化合物、组合物和方法。其中，描述了公式G-L-E的化合物，其中G是一个亲脂性基团，L是一个可断裂的连接基团，E是一个电泳基团。这些化合物与膜相关联，并且可以通过断裂诱导基团进行断裂，从而释放可检测的电泳基团。
• [EN] O-NITROBENZYL PHOTOCLEAVABLE BIFUNCTIONAL LINKER<br/>[FR] LIEUR BIFONCTIONNEL PHOTOCLIVABLE O-NITROBENZYLE
  申请人：NANOSTRING TECHNOLOGIES INC

  公开号：WO2019104070A1

  公开（公告）日：2019-05-31

  Disclosed herein is an ortho-nitrobenzyl compound, or a stereoisomer or salt thereof, and a composition comprising the same, as well as processes for the preparation of the same. Also disclosed herein is a method of using the ortho-nitrobenzyl compound, or a stereoisomer thereof, in probes capable of hybridizing to, detecting or sequencing nucleic acid molecules.

  本文公开了一种邻硝基苄基化合物，或其立体异构体或盐，以及包含该化合物的组合物，并公开了制备该化合物的方法。本文还公开了一种使用该邻硝基苄基化合物或其立体异构体在探针中的方法，该探针能够杂交到、检测或测序核酸分子。
• Electrophoretic tag reagents comprising fluorescent compounds
  申请人：Aclara BioSciences, Inc.

  公开号：US20020146726A1

  公开（公告）日：2002-10-10

  Electrophoretic probes comprising fluorescent compounds as detection groups and mobility modifiers are disclosed for the multiplexed detection of the binding of, or interaction between, one or more ligands and target antiligands are provided. In one embodiment, detection involves the release of identifying tags as a consequence of target recognition. Target antiligands are contacted with a set of e-tag probes and the contacted antiligands are treated with a selected cleaving agent resulting in a mixture of e-tag reporters. Typically, uncleaved or partially cleaved e-tag probes are removed and the mixture of e-tag reporters is separated by any technique that provides for separation by mass or mass to charge ratio and the like and detected to provide for target identification.

  本发明提供了一种包含荧光化合物作为检测组和迁移修饰剂的电泳探针，用于多重检测一种或多种配体与目标抗配体之间的结合或相互作用。在一种实施方式中，检测涉及识别标签的释放，作为目标识别的结果。目标抗配体与一组e-tag探针接触，接触的抗配体经过选择的切割剂处理，导致e-tag报告物的混合物。通常，未切割或部分切割的e-tag探针被移除，e-tag报告物的混合物通过任何提供按质量或质量对电荷比分离的技术进行分离，并检测以提供目标识别。