5-甲氧基铁屎米酮 | 15071-56-4

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吲哚萘啶生物碱
• 中文名称: 5-甲氧基铁屎米酮
• 英文名称: 5-methoxycanthin-6-one
• 英文别名: 5-methoxy-canthin-6-one；5-methoxy-indolo[3,2,1-de][1,5]naphthyridin-6-one；5-Methoxy-indolo[3,2,1-de][1,5]naphthyridin-6-on；5-Methoxy-canthinon-(6)；5-Methoxy-canthin-6-on；5-Methoxy-6-canthinon；3-methoxy-1,6-diazatetracyclo[7.6.1.05,16.010,15]hexadeca-3,5(16),6,8,10,12,14-heptaen-2-one
• CAS: 15071-56-4
• 化学式: C₁₅H₁₀N₂O₂
• 分子量: 250.257
• InChiKey: TXEFUSAHPIYZHD-UHFFFAOYSA-N

物化性质

• 沸点：
  397.4±42.0 °C(Predicted)
• 密度：
  1.40±0.1 g/cm3(Predicted)
• 物理描述：
  Solid
• 熔点：
  243-244°C

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  44.1
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  5-甲氧基铁屎米酮 在 氢氧化钾 作用下， 生成 3c-(9H-β-carbolin-1-yl)-2-methoxy-acrylic acid
  参考文献：
  名称：

  Nelson; Price, Australian Journal of Scientific Research, Series A: Physical Sciences, 1952, vol. 5, p. 563,567

  摘要：

  DOI：
• 作为产物：
  描述：

  3-Benzyl-3H-indolo[3,2,1-de][1,5]naphthyridine-5,6-dione 在 palladium on activated charcoal 、 氢气 氢气 、 溶剂黄146 作用下， 反应 1.0h， 生成 5-甲氧基铁屎米酮
  参考文献：
  名称：

  An unusually simple procedure for the synthesis of canthin-alkaloid derivatives using dialkyl oxalates as new regioselective N-alkylating agents

  摘要：

  DOI：

  10.1016/s0040-4039(01)80824-8

文献信息

• USE OF CANTHIN-6-ONE AND ITS ANALOGS IN THE TREATMENT OF MYCOBACTERIA-LINKED PATHOLOGIES ( amended
  申请人：Fournet Alain Robert Francois Maxime

  公开号：US20110059977A1

  公开（公告）日：2011-03-10

  The present invention relates to the use, for the preparation of a medicament intended for the treatment or the prevention of pathologies linked to, or caused by mycobacteria, of at least one of the compounds of the following formula (I): in which B represents in particular a nitrogen atom, and R1, R2, R3, R4, R5, R6, R7 and R8 represent in particular a hydrogen atom.

  本发明涉及使用以下式(I)中至少一种化合物，用于制备用于治疗或预防与分支杆菌相关或由其引起的病理状况的药物，其中B特别代表氮原子，而R1、R2、R3、R4、R5、R6、R7和R8特别代表氢原子。
• Studies on the alkaloids from Picrasma quassioides BENNET. V. Structures of picrasidines L,M, and P.
  作者：TAICHI OHMOTO、KAZUO KOIKE

  DOI：10.1248/cpb.33.3847

  日期：——

  Two new alkaloids, picrasidines M (II) and P (III), have been isolated from the root-bark of Picrasma quassioides BENNET. The structure of picrasidine L has been revised from 3-methyl-canthin-2, 6-dione to 3-methylcanthin-5, 6-dione (I). The structures were determined on the basis of spectral analysis and chemical evidence.

  从苦木（Picrasma quassioides BENNET）的根皮中分离出两种新的生物碱——苦木碱M（II）和苦木碱P（III）。苦木碱L的结构已从3-甲基-坎亭-2,6-二酮修改为3-甲基坎亭-5,6-二酮（I）。这些结构是根据光谱分析和化学证据确定的。
• Extraction, Hemisynthesis, and Synthesis of Canthin-6-one Analogues. Evaluation of Their Antifungal Activities
  作者：Flor Soriano-Agatón、Delphine Lagoutte、Erwan Poupon、François Roblot、Alain Fournet、Jean-Charles Gantier、Reynald Hocquemiller

  DOI：10.1021/np050250z

  日期：2005.11.1

  Zanthoxylum chiloperone var. angustifolium was investigated. Alkaloids 1-3 from the canthin-6-one series were characterized. Derivatives 7-28 were prepared by hemisynthesis or total synthesis. All compounds were tested for in vitro antifungal activities against five pathogenic fungal strains. Analogues of canthin-6-one did not show better antifungal activities.
• Nelson; Price, Australian Journal of Scientific Research, Series A: Physical Sciences, 1952, vol. <A> 5, p. 563,567
  作者：Nelson、Price

  DOI：——

  日期：——
• UTILISATION DE LA CANTHIN-6-ONE ET SES ANALOGUES DANS LE TRAITEMENT DES PATHOLOGIES LIEES AUX MYCOBACTERIES
  申请人：Institut de Recherche pour le Développement

  公开号：EP1998770B1

  公开（公告）日：2010-04-21