1-[3-[4-羟基-3-(碘-125I)苯基]-1-氧代丙氧基]-2,5-吡咯烷二酮 | 65114-37-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 1-[3-[4-羟基-3-(碘-125I)苯基]-1-氧代丙氧基]-2,5-吡咯烷二酮
• 英文名称: Bolton-Hunter reagent
• 英文别名: N-succinimidyl-3-(4-hydroxy-3-<¹²⁵I>iodophenyl)propionate；N-succinimidyl 3-(4-hydroxy-3-(125I)iodophenyl) propionate；N-succinimidyl-3-(4-hydroxy-3-[¹²⁵I]iodophenyl)propionate；N-Hydroxysuccinimide iodo-p-hydroxyphenylpropionate；(2,5-dioxopyrrolidin-1-yl) 3-(4-hydroxy-3-(125I)iodanylphenyl)propanoate
• CAS: 65114-37-6
• 化学式: C₁₃H₁₂INO₅
• 分子量: 387.242
• InChiKey: JITCCUITUOPXAR-XSBOKVBDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  83.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-氨基尿嘧啶 、 1-[3-[4-羟基-3-(碘-125I)苯基]-1-氧代丙氧基]-2,5-吡咯烷二酮 以 乙腈 为溶剂， 生成
  参考文献：
  名称：

  Synthetic polymer membranes with molecular recognition

  摘要：

  描述了大孔静电纺丝聚醚聚氨酯膜的合成，该膜经过功能化以显示尿嘧啶衍生物的分子识别。

  DOI：

  10.1039/c39930001580

文献信息

• Synthesis of a 125I-labelled derivative of 25-hydroxyvitamin D3
  作者：Miyuki Tanabe、Massaya Harada、Shigeru Ikuta、Nobuaki Nakagawa、Masaru Otani

  DOI：10.1039/c39890001220

  日期：——

  The facile synthesis of a radioactive 25-hydroxyvitamin D3 derivative which is labelled with 125l-Bolton–Hunter Reagent is described.

  描述了用125 l-Bolton-Hunter试剂标记的放射性25-羟基维生素D 3衍生物的简便合成方法。
• Synthesis and purification of desmethylzopiclone-N-{3-(4-hydroxy-3-[125I]-iodophenyl) propionamide}, a prosthetic derivative of zopiclone for use in immunoassay
  作者：E. Mannaert、P. Daenens

  DOI：10.1002/jlcr.2580340311

  日期：1994.3

  Condensation of [125I]-Bolton/Hunter reagent with N-desmethylzopiclone lead to the title compound which was isolated and purified by normal phase HPLC, in combination with gamma counting detection. The introduction of the prosthetic group into the tracer precursor was proven by L-SIMS.

  将[125I]-Bolton/Hunter试剂与N-去甲基佐匹克隆缩合，得到了标题化合物，并通过正相高效液相色谱法和伽马计数检测分离和纯化了该化合物。通过 L-SIMS 验证了在示踪剂前体中引入了人工基团。
• RADIOIODINATION METHOD
  申请人：Avory Michelle

  公开号：US20110280803A1

  公开（公告）日：2011-11-17

  The present invention provides a method for the synthesis of radioiodinated compounds which is advantageous over prior art methods. Using a hydrazine or an aminoxy in place of a primary amine for indirect radioiodination facilitates a much quicker reaction thus reducing reaction time and increasing the yield. In addition, where there are primary amines in the molecule to be radioiodinated, such as the N-terminus of a peptide or lysine residues, reaction at the hydrazine or aminoxy is greatly favoured.

  本发明提供了一种合成放射性碘化合物的方法，相比先前的方法具有优势。使用肼或氨氧基代替一级胺来进行间接放射性碘化反应，可以加快反应速度，从而减少反应时间并增加产量。此外，如果分子中存在一级胺，例如肽的N-末端或赖氨酸残基，则在肼或氨氧基处进行反应的倾向性大大增加。
• Radiolabelling Method Using Cycloalkyl Groups
  申请人：Graham Keith

  公开号：US20120189546A1

  公开（公告）日：2012-07-26

  This invention relates to novel cyclo alkyl compounds suitable for labeling by 18 F, methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging by positron emission tomography (PET).

  本发明涉及新型环烷基化合物，适用于18F标记，制备这种化合物的方法，包含这种化合物的组合物，包含这种化合物或组合物的试剂盒以及这种化合物、组合物或试剂盒在正电子发射断层扫描（PET）诊断成像中的用途。
• TANABA, MIYUKI;HARADA, MASAYA;IKUTA, SHIGERU;NAKAGAWA, NOBUAKI;OTANI, MAS+, J. CHEM. SOC. CHEM. COMMUN.,(1989) N7, C. 1220-1221
  作者：TANABA, MIYUKI、HARADA, MASAYA、IKUTA, SHIGERU、NAKAGAWA, NOBUAKI、OTANI, MAS+

  DOI：——

  日期：——