7-methoxy-2-(phenylhydrazono)-2H-chromene-3-carbonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 7-methoxy-2-(phenylhydrazono)-2H-chromene-3-carbonitrile
• 英文别名: (2E)-7-methoxy-2-(phenylhydrazinylidene)chromene-3-carbonitrile
• 化学式: C₁₇H₁₃N₃O₂
• 分子量: 291.309
• InChiKey: AREQGOPDMMDRLE-LVZFUZTISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  66.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-羟基-4-甲氧基苯甲醛 在 哌啶 、 ammonium acetate 、 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 1.5h， 生成 7-methoxy-2-(phenylhydrazono)-2H-chromene-3-carbonitrile
  参考文献：
  名称：

  Synthesis of new iminocoumarins and their transformations into N-chloro and hydrazono compounds

  摘要：

  The Knoevenagel reaction between 2-hydroxybenzaldehydes and active methylene compounds (malononitrile and ethyl cyanoacetate) produces iminocoumarins and/or coumarins. In order to study the reactivity of the prepared iminocoumarins, chlorination and reaction with N-nucleophiles were studied. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.05.020

文献信息

• Synthesis of new iminocoumarins and their transformations into N-chloro and hydrazono compounds
  作者：Julija Volmajer、Renata Toplak、Ivan Leban、Alenka Majcen Le Marechal

  DOI：10.1016/j.tet.2005.05.020

  日期：2005.7

  The Knoevenagel reaction between 2-hydroxybenzaldehydes and active methylene compounds (malononitrile and ethyl cyanoacetate) produces iminocoumarins and/or coumarins. In order to study the reactivity of the prepared iminocoumarins, chlorination and reaction with N-nucleophiles were studied. (c) 2005 Elsevier Ltd. All rights reserved.