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5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenylamine | 722519-44-0

中文名称
——
中文别名
——
英文名称
5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenylamine
英文别名
5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)aniline
5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenylamine化学式
CAS
722519-44-0
化学式
C18H21NO2
mdl
——
分子量
283.37
InChiKey
ZCAVEJXGCZOGGO-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    3.8
  • 重原子数:
    21
  • 可旋转键数:
    3
  • 环数:
    3.0
  • sp3杂化的碳原子比例:
    0.33
  • 拓扑面积:
    44.5
  • 氢给体数:
    1
  • 氢受体数:
    3

上下游信息

  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为反应物:
    描述:
    5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenylamine 在 palladium on activated charcoal 、 氢气 作用下, 生成
    参考文献:
    名称:
    [EN] ESTROGEN RECEPTOR TARGETING ANTAGONISTS
    [FR] ANTAGONISTES CIBLANT LE RÉCEPTEUR DES OESTROGÈNES
    摘要:
    本公开涉及通过非共价或共价结合到ER配体结合结构域的化合物,作为拮抗剂或同时作为拮抗剂和ER蛋白降解剂,并且涉及这些化合物的合成。此外,本公开教导了利用这些化合物治疗增殖性疾病,包括癌症,特别是乳腺癌,尤其是ER+乳腺癌。
    公开号:
    WO2020055973A1
  • 作为产物:
    描述:
    参考文献:
    名称:
    [EN] ESTROGEN RECEPTOR TARGETING ANTAGONISTS
    [FR] ANTAGONISTES CIBLANT LE RÉCEPTEUR DES OESTROGÈNES
    摘要:
    本公开涉及通过非共价或共价结合到ER配体结合结构域的化合物,作为拮抗剂或同时作为拮抗剂和ER蛋白降解剂,并且涉及这些化合物的合成。此外,本公开教导了利用这些化合物治疗增殖性疾病,包括癌症,特别是乳腺癌,尤其是ER+乳腺癌。
    公开号:
    WO2020055973A1
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文献信息

  • Selective Estrogen Receptor Modulator
    申请人:Hamaoka Shinichi
    公开号:US20120004315A1
    公开(公告)日:2012-01-05
    The present invention provides a compound represented by the following formula (I); [wherein T represents a single bond, a C1-C4 alkylene group which may have a substituent and the like; formula (I-1) represents a single bond or a double bond; A represents a single bond, a bivalent 5- to 14-membered heterocyclic group which may have a substituent and the like; Y represents a single bond and the like; Z represents a methylene group and the like; ring G represents a phenylene group and the like which may condense with a 5- to 6-membered ring and may have a heteroatom; R a and R b are the same as or different from each other and represent a hydrogen atom and the like; W represents a single bond and the like; R′ represents 1 to 4 independent hydrogen atoms and the like; and R″ represents 1 to 4 independent hydrogen atoms and the like] or a salt thereof, or a hydrate thereof.
    本发明提供一种由以下式(I)表示的化合物; [其中T表示单键,可能具有取代基的C1-C4烷基和类似物;式(I-1)表示单键或双键;A表示单键,可能具有取代基的双价5-至14-成员杂环基和类似物;Y表示单键和类似物;Z表示亚甲基基团和类似物;环G表示苯基团和类似物,可能与5-至6-成员环缩合并可能具有杂原子;Ra和Rb相同或不同,表示氢原子和类似物;W表示单键和类似物;R'表示1到4个独立的氢原子和类似物;R''表示1到4个独立的氢原子和类似物]或其盐或水合物。
  • Selective estrogen receptor modulator
    申请人:Hamaoka Shinichi
    公开号:US20060116364A1
    公开(公告)日:2006-06-01
    The present invention provides a compound represented by the following formula [wherein T represents a single bond, a C1-C4 alkylene group which may have a substituent and the like; formula (I-1) represents a single bond or a double bond; A represents a single bond, a bivalent 5- to 14-membered heterocyclic group which may have a substituent and the like; Y represents a single bond and the like; Z represents a methylene group and the like; ring G represents a phenylene group and the like which may condense with a 5- to 6-membered ring and may have a heteroatom; R a and R b are the same as or different from each other and represent a hydrogen atom and the like; W represents a single bond and the like; R′ represents 1 to 4 independent hydrogen atoms and the like; and R″ represents 1 to 4 independent hydrogen atoms and the like] or a salt thereof, or a hydrate thereof
    本发明提供了一种化合物,其表示为以下式子[其中T表示单键,C1-C4的烷基,可能带有取代基等;式(I-1)表示单键或双键;A表示单键,二价的5-至14-成员杂环基团,可能带有取代基等;Y表示单键等;Z表示亚甲基等;环G表示苯基团等,可与5-至6-成员环缩合并且可能具有杂原子;Ra和Rb相同或不同,表示氢原子等;W表示单键等;R'表示1至4个独立的氢原子等;R"表示1至4个独立的氢原子等]或其盐,或其水合物。
  • SELECTIVE ESTROGEN RECEPTOR MODULATOR
    申请人:Hamaoka Shinichi
    公开号:US20090325930A1
    公开(公告)日:2009-12-31
    The present invention provides a compound represented by the following formula (I); [wherein T represents a single bond, a C1-C4 alkylene group which may have a substituent and the like; (I-1) formula (I-1) represents a single bond or a double bond; A represents a single bond, a bivalent 5- to 14-membered heterocyclic group which may have a substituent and the like; Y represents a single bond and the like; Z represents a methylene group and the like; ring G represents a phenylene group and the like which may condense with a 5- to 6-membered ring and may have a heteroatom; R a and R b are the same as or different from each other and represent a hydrogen atom and the like; W represents a single bond and the like; R′ represents 1 to 4 independent hydrogen atoms and the like; and R″ represents 1 to 4 independent hydrogen atoms and the like] or a salt thereof, or a hydrate thereof.
    本发明提供了一种由以下式(I)表示的化合物;[其中,T表示单键,C1-C4烷基,可以有取代基等;(I-1)式(I-1)表示单键或双键;A表示单键,双价的5-至14-成员杂环基,可以有取代基等;Y表示单键等;Z表示亚甲基等;环G表示苯基等,可以与5-至6-成员环缩合,可以有杂原子;Ra和Rb相同或不同,表示氢原子等;W表示单键等;R′表示1至4个独立的氢原子等;R″表示1至4个独立的氢原子等]或其盐,或其水合物。
  • SELECTIVE ESTROGEN RECEPTOR MODULATORS
    申请人:Eisai Co., Ltd.
    公开号:EP1577288A1
    公开(公告)日:2005-09-21
    The present invention provides a compound represented by the following formula (I); [wherein T represents a single bond, a C1-C4 alkylene group which may have a substituent and the like; formula (I-1) represents a single bond or a double bond; A represents a single bond, a bivalent 5- to 14-membered heterocyclic group which may have a substituent and the like; Y represents a single bond and the like; Z represents a methylene group and the like; ring G represents a phenylene group and the like which may condense with a 5- to 6-membered ring and may have a heteroatom; Ra and Rb are the same as or different from each other and represent a hydrogen atom and the like; W represents a single bond and the like; R' represents 1 to 4 independent hydrogen atoms and the like; and R" represents 1 to 4 independent hydrogen atoms and the like] or a salt thereof, or a hydrate thereof.
    本发明提供了由下式(I)代表的化合物; [其中 T 代表单键、可能具有取代基的 C1-C4 亚烷基等; 式(I-1)代表单键或双键;A 代表单键、可具有取代基等的二价 5 至 14 元杂环基团;Y 代表单键等;Z 代表亚甲基等;环 G 代表可与 5 至 6 元环缩合且可具有杂原子的亚苯基等;Ra和Rb彼此相同或不同,代表氢原子等;W代表单键等;R'代表1至4个独立氢原子等;R "代表1至4个独立氢原子等]或其盐或其水合物。
  • Selective estrogen receptor modulators
    申请人:Eisai R&D Management Co., Ltd.
    公开号:EP1577288B1
    公开(公告)日:2014-07-23
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