(2S)-1-[tert-butyl(dimethyl)silyl]oxyheptadecan-2-ol | 930269-28-6

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: (2S)-1-[tert-butyl(dimethyl)silyl]oxyheptadecan-2-ol
• CAS: 930269-28-6
• 化学式: C₂₃H₅₀O₂Si
• 分子量: 386.734
• InChiKey: PWVSIXQIQSIWLP-QFIPXVFZSA-N

物化性质

• 沸点：
  434.9±28.0 °C(predicted)
• 密度：
  0.862±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.85
• 重原子数：
  26
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2S)-1-[tert-butyl(dimethyl)silyl]oxyheptadecan-2-ol 在 4-二甲氨基吡啶 、 草酰氯 、 四丁基氟化铵 作用下， 以 四氢呋喃 、 二氯甲烷 、 二甲基亚砜 为溶剂， 反应 6.0h， 生成 [(2S)-1-oxoheptadecan-2-yl] acetate
  参考文献：
  名称：

  Study of the synthesis of poecillanosine

  摘要：

  The synthesis of poecillanosine, a natural N-hydroxy-N-nitroso-alkylamine compound, was studied. Poecillanosine was shown to be unstable under acidic nitrosation conditions. Only degradation compounds of poecillanosine were obtained under such conditions, however, the O-methyl derivative of poecillanosine was synthesised and confirmed. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.12.059
• 作为产物：
  描述：

  正十四烷基三苯基溴化膦 在 palladium on activated charcoal 4-二甲氨基吡啶 、 正丁基锂 、 氢气 、 三乙胺 作用下， 以 四氢呋喃 、 正己烷 、 二氯甲烷 、 乙酸乙酯 为溶剂， 20.0 ℃ 、344.74 kPa 条件下， 反应 86.0h， 生成 (2S)-1-[tert-butyl(dimethyl)silyl]oxyheptadecan-2-ol
  参考文献：
  名称：

  Study of the synthesis of poecillanosine

  摘要：

  The synthesis of poecillanosine, a natural N-hydroxy-N-nitroso-alkylamine compound, was studied. Poecillanosine was shown to be unstable under acidic nitrosation conditions. Only degradation compounds of poecillanosine were obtained under such conditions, however, the O-methyl derivative of poecillanosine was synthesised and confirmed. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.12.059

文献信息

• Study of the synthesis of poecillanosine
  作者：Ming Xian、Brian J. Shuhler

  DOI：10.1016/j.tetlet.2006.12.059

  日期：2007.2

  The synthesis of poecillanosine, a natural N-hydroxy-N-nitroso-alkylamine compound, was studied. Poecillanosine was shown to be unstable under acidic nitrosation conditions. Only degradation compounds of poecillanosine were obtained under such conditions, however, the O-methyl derivative of poecillanosine was synthesised and confirmed. (c) 2006 Elsevier Ltd. All rights reserved.