2-氯萘-1-磺酰氯 | 102154-19-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 2-氯萘-1-磺酰氯
• 英文名称: 2-chloro-naphthalene-1-sulfonyl chloride
• 英文别名: 2-Chlor-naphthalin-1-sulfonylchlorid；2-Chloronaphthalene-1-sulfonyl chloride
• CAS: 102154-19-8
• 化学式: C₁₀H₆Cl₂O₂S
• mdl: MFCD22196559
• 分子量: 261.128
• InChiKey: SPRZLGGRDIRMRD-UHFFFAOYSA-N

物化性质

• 沸点：
  376.3±25.0 °C(Predicted)
• 密度：
  1.516±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-氯萘-1-磺酰氯 在 硫酸 、 sodium ethanolate 、 锌 作用下， 生成 (2-chloro-[1]naphthylsulfanyl)-acetaldehyde dimethylacetal
  参考文献：
  名称：

  Dikshit; Tilak, Proceedings - Indian Academy of Sciences, Section A, 1951, # 33, p. 78,82

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 五氯化磷 作用下， 生成 2-氯萘-1-磺酰氯
  参考文献：
  名称：

  Certain Dichloronaphthalenes and Related Intermediates

  摘要：

  DOI：

  10.1021/ja01331a037

文献信息

• SUBSTITUTED SULFONAMIDE COMPOUNDS
  申请人：OBERBOERSCH Stefan

  公开号：US20080153843A1

  公开（公告）日：2008-06-26

  Substituted sulfonamide derivatives, a process for their preparation, pharmaceutical compositions containing these compounds, and to the use of substituted sulfonamide derivatives in the treatment or inhibition of pain and/or various disorders or disease states.

  磺胺取代物，其制备方法，含有这些化合物的药物组合物，以及磺胺取代物在治疗或抑制疼痛和/或各种疾病或疾病状态中的用途。
• [EN] 2-SULFONYLAMINO-4-HETEROARYL BUTYRAMIDE ANTAGONISTS OF CCR10<br/>[FR] ANTAGONISTES DE 2-SULFONYLAMINO-4-HÉTÉROARYL BUTYRAMIDE DE CCR10
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2009126675A1

  公开（公告）日：2009-10-15

  This invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein R1, R2, R4. Ar and Het are as defined herein. The invention also relates to methods of using the compound of formula (I) to treat a diseases and disorders that are mediated or sustained through the activity of CCR10.

  本发明涉及一种具有式（I）的化合物及其药学上可接受的盐，其中R1、R2、R4、Ar和Het如本文中所定义。该发明还涉及使用式（I）的化合物治疗通过CCR10活性介导或维持的疾病和紊乱的方法。
• Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors
  申请人：——

  公开号：US20020007070A1

  公开（公告）日：2002-01-17

  Aminoguanidine and alkoxyguanidine compounds are described, including compounds of the Formula VII: 1 wherein X is O or NR 9 and Het, R 1 , R 7 , R 8 , R 12 -R 15 , R a , R b , R c , Z, and n are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin. Also described are methods for preparing such compounds. The compounds of the invention are potent inhibitors of proteases, especially trypsin-like serine proteases, such as chymotrypsin, trypsin, thrombin, plasmin and factor Xa. Certain of the compounds exhibit antithrombotic activity via direct, selective inhibition of thrombin. The invention includes a composition for inhibiting loss of blood platelets, inhibiting formation of blood platelet aggregates, inhibiting formation of fibrin, inhibiting thrombus formation, and inhibiting embolus formation in a mammal, comprising a compound of the invention in a pharmaceutically acceptable carrier. Other uses of compounds of the invention are as anticoagulants either embedded in or physically linked to materials used in the manufacture of devices used in blood collection, blood circulation, and blood storage, such as catheters, blood dialysis machines, blood collection syringes and tubes, blood lines and stents. Additionally, the compounds can be detectably labeled and employed for in vivo imaging of thrombi.

  本文描述了氨基胍和烷氧基胍化合物，包括公式VII：其中X为O或NR9，Het，R1，R7，R8，R12-R15，Ra，Rb，Rc，Z和n在规范中列出，以及其水合物，溶剂化物或药学上可接受的盐，可抑制蛋白酶酶如凝血酶。还描述了制备这种化合物的方法。本发明的化合物是蛋白酶的强效抑制剂，特别是胰蛋白酶样丝氨酸蛋白酶，如胰蛋白酶，凝血酶，纤溶酶和Xa因子。其中一些化合物通过直接、选择性地抑制凝血酶表现出抗血栓活性。本发明包括一种用于抑制哺乳动物中血小板丢失、抑制血小板聚集、抑制纤维蛋白形成、抑制血栓形成和抑制栓塞形成的组合物，其中包含本发明的化合物和药学上可接受的载体。本发明的化合物的其他用途是作为抗凝剂嵌入或物理连接到用于血液收集、血液循环和血液储存的器械制造中使用的材料中，例如导管、血液透析机、血液采集注射器和管、血液管路和支架。此外，这些化合物可以被检测标记并用于体内血栓的成像。
• Heteroaryl aminoguanidine and alkoxyguanidines and their use as protease inhibitors
  申请人：Lu Tianbao

  公开号：US20060211719A1

  公开（公告）日：2006-09-21

  Aminoguanidine and alkoxyguanidine compounds are described, including compounds of the Formula VII: wherein X is O or NR 9 and Het, R 1 , R 7 , R 8 , R 12 -R 15 , R a , R b , R c , Z, and n are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin. Also described are methods for preparing such compounds. The compounds of the invention are potent inhibitors of proteases, especially trypsin-like serine proteases, such as chymotrypsin, trypsin, thrombin, plasmin and factor Xa. Certain of the compounds exhibit antithrombotic activity via direct, selective inhibition of thrombin. The invention includes a composition for inhibiting loss of blood platelets, inhibiting formation of blood platelet aggregates, inhibiting formation of fibrin, inhibiting thrombus formation, and inhibiting embolus formation in a mammal, comprising a compound of the invention in a pharmaceutically acceptable carrier. Other uses of compounds of the invention are as anticoagulants either embedded in or physically linked to materials used in the manufacture of devices used in blood collection, blood circulation, and blood storage, such as catheters, blood dialysis machines, blood collection syringes and tubes, blood lines and stents. Additionally, the compounds can be detectably labeled and employed for in vivo imaging of thrombi.

  本文描述了氨基胍和烷氧基胍类化合物，包括式VII的化合物：其中X为O或NR9，Het、R1、R7、R8、R12-R15、Ra、Rb、Rc、Z和n在规范中列出，以及其水合物、溶剂化合物或药学上可接受的盐，可抑制蛋白酶，如凝血酶。还描述了制备这种化合物的方法。该发明的化合物是蛋白酶的有效抑制剂，特别是类胰蛋白酶的丝氨酸蛋白酶，如胰蛋白酶、凝血酶、纤溶酶和Xa因子。其中某些化合物通过直接、选择性地抑制凝血酶表现出抗血栓作用。该发明包括一种组合物，用于抑制哺乳动物中的血小板丢失、抑制血小板聚集、抑制纤维蛋白形成、抑制血栓形成和抑制栓子形成，其包括该发明的化合物和药学上可接受的载体。该发明的化合物的其他用途是作为抗凝剂嵌入或物理连接到用于血液采集、血液循环和血液储存的器械的制造材料中，如导管、血液透析机、血液采集注射器和管子、血液管路和支架。此外，这些化合物可以被标记并用于体内血栓的成像。
• Substituted Sulfonamide Compounds
  申请人：OBERBOERSCH Stefan

  公开号：US20100324009A1

  公开（公告）日：2010-12-23

  Substituted sulfonamide derivatives, a process for their preparation, pharmaceutical compositions containing these compounds, and to the use of substituted sulfonamide derivatives in the treatment or inhibition of pain and/or various disorders or disease states.

  替代磺酰胺衍生物，其制备方法，含有这些化合物的制药组合物，以及使用替代磺酰胺衍生物治疗或抑制疼痛和/或各种紊乱或疾病状态。