N-tetrahydrothiopyran-4-yl-acetamide | 849048-10-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻烷
• 英文名称: N-tetrahydrothiopyran-4-yl-acetamide
• 英文别名: N-Tetrahydrothiopyran-4-yl-acetamid；N-(thian-4-yl)acetamide
• CAS: 849048-10-8
• 化学式: C₇H₁₃NOS
• 分子量: 159.252
• InChiKey: FCTFVCBQSPEMCI-UHFFFAOYSA-N

物化性质

• 沸点：
  351.7±31.0 °C(Predicted)
• 密度：
  1.09±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-tetrahydrothiopyran-4-yl-acetamide 在 双氧水 作用下， 生成 N-(1,1-dioxo-tetrahydro-1λ⁶-thiopyran-4-yl)-acetamide
  参考文献：
  名称：

  Some Derivatives of Tetrahydrothiapyran as Possible Local Anesthetics

  摘要：

  DOI：

  10.1021/ja01619a056
• 作为产物：
  描述：

  四氢噻喃-4-胺 生成 N-tetrahydrothiopyran-4-yl-acetamide
  参考文献：
  名称：

  Some Derivatives of Tetrahydrothiapyran as Possible Local Anesthetics

  摘要：

  DOI：

  10.1021/ja01619a056

文献信息

• [EN] 2-PHENYL-3H-IMIDAZO[4,5-B]PYRIDINE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN TYROSINE KINASE ROR1 ACTIVITY<br/>[FR] DÉRIVÉS DE 2-PHÉNYL-3H-IMIDAZO[4,5-B]PYRIDINE UTILISÉS COMME INHIBITEURS DE L'ACTIVITÉ DE LA TYROSINE KINASE DE MAMMIFÈRE ROR1
  申请人：KANCERA AB

  公开号：WO2016124553A1

  公开（公告）日：2016-08-11

  A compound of formula (I´) or (I´´) or a pharmaceutically acceptable salt thereof. The compound is an inhibitor of mammalian kinase enzyme activity, including ROR1 tyrosine kinase activity and may be used in the treatment of disorders associated with such activity.

  化合物的化学式（I´）或（I´´）或其药学上可接受的盐。该化合物是哺乳动物激酶酶活性的抑制剂，包括ROR1酪氨酸激酶活性，并可用于治疗与该活性相关的疾病。
• [EN] FORMAMIDE DERIVATIVES USEFUL AS ADRENOCEPTOR<br/>[FR] DERIVES DE FORMAMIDE UTILES COMME RECEPTEURS ADRENERGIQUES
  申请人：PFIZER LTD

  公开号：WO2005092840A1

  公开（公告）日：2005-10-06

  The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.

  该发明涉及公式（1）的化合物，以及用于制备、用于制备的中间体、含有和用途的过程。根据本发明的化合物在许多疾病、紊乱和情况中都有用，特别是在炎症、过敏和呼吸系统疾病、紊乱和情况中。
• SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY
  申请人：GNAMM Christian

  公开号：US20140221335A1

  公开（公告）日：2014-08-07

  This invention relates to substituted bicyclic dihydropyrimidinones of formula 1 and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other autoimmune and allergic disorders, allograft rejection, and oncological diseases.

  该发明涉及式1的取代双环二氢嘧啶酮及其用作中性粒细胞弹性蛋白酶活性抑制剂的药物组合物，以及使用它们作为治疗和/或预防肺部、胃肠道和泌尿系统疾病、皮肤和眼部炎症性疾病、以及其他自身免疫和过敏性疾病、移植物排斥反应和肿瘤性疾病的药剂的方法。
• NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND USE OF SAME
  申请人：Shirai Junya

  公开号：US20110178060A1

  公开（公告）日：2011-07-21

  The present invention relates to a compound represented by the formula wherein ring A is a nitrogen-containing heterocycle; ring B is an aromatic ring optionally having substituent(s); ring D is an aromatic ring optionally having substituent(s); L is a group represented by the formula R 2 , R 3 , R 4a and R 4b are each independently a hydrogen atom, an optionally halogenated C 1-6 alkyl group or an optionally halogenated C 3-6 cycloalkyl group, or R 2 and R 3 are optionally bonded via an alkylene chain or an alkenylene chain, or R 4a and R 4b are optionally bonded via an alkylene chain or an alkenylene chain; R 1 is a hydrogen atom or a substituent; m and n are each independently an integer of 0 to 5; m+n is an integer of 2 to 5; and is a single bond or double bond, or a salt thereof; and the like. The compound has a superior tachykinin receptor antagonistic action, and is useful as an agent for the prophylaxis or treatment of various diseases such as lower urinary tract diseases, digestive tract diseases, central neurological disease and the like.

  本发明涉及一种化合物，其表示为式： 其中，环A是一种含氮杂环；环B是一种芳香环，可选地具有取代基；环D是一种芳香环，可选地具有取代基；L是一个代表式为R2、R3、R4a和R4b的基团，其中R2、R3、R4a和R4b各自独立地是氢原子、可选卤代的C1-6烷基或可选卤代的C3-6环烷基，或者R2和R3通过烷基链或烯基链可选地连接，或者R4a和R4b通过烷基链或烯基链可选地连接；R1是氢原子或取代基；m和n各自独立地为0到5的整数；m+n是2到5的整数；以及为单键或双键，或其盐；等等。该化合物具有优良的缩氨酸受体拮抗作用，并可用作预防或治疗各种疾病的药剂，如下尿路疾病、消化道疾病、中枢神经系统疾病等。
• Flavin-Mediated Photocatalysis Provides a General Platform for Sulfide C–H Functionalization
  作者：Alex S. Anderton、Oliver J. Knowles、James A. Rossi-Ashton、David J. Procter

  DOI：10.1021/acscatal.3c05785

  日期：2024.2.16

  Functionalized sulfides are important in many areas of science, ranging from chemical biology through drug discovery to organic materials chemistry. Sulfides bearing pendant reactive groups in the α-position are particularly useful; however, methods for the selective valorization of simple sulfides or the late-stage functionalization of complex sulfides by the convenient addition of valuable functionality

  功能化硫化物在许多科学领域都很重要，从化学生物学到药物发现再到有机材料化学。在 α 位带有反应性侧基的硫化物特别有用；然而，选择性增值简单硫化物或通过方便添加有价值的官能团对复杂硫化物进行后期功能化的方法尚未得到充分探索。在这里，我们通过展示 α-硫 C-H 官能化的三种模式来举例说明硫醚官能化的通用反应平台；氰化、烯基化和炔基化。使用廉价且市售的核黄素四乙酸酯和可见光，可以以良好的产率和高选择性对原料和复合硫化物进行修饰。含蛋氨酸的肽也可以选择性地功能化，并且使用氨基酸掺杂剂的耐受性筛选表明该平台与大多数氨基酸侧链相容，因此是生物共轭的潜在工具。