2-(羟基亚胺)-3-(2-硝基苯基)丙酸 | 27878-36-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 中文名称: 2-(羟基亚胺)-3-(2-硝基苯基)丙酸
• 中文别名: 2-(肟基)-3-(o-硝基苯基)丙酸
• 英文名称: Oxim v. o-Nitrophenylpyruvicsaeure
• 英文别名: 2-hydroxyimino-3-(2-nitro-phenyl)-propionic acid；2-Hydroxyimino-3-(2-nitro-phenyl)-propionsaeure；α-Oximino-β-(2-nitro-phenyl)-propionsaeure；2-Nitro-phenylbrenztraubensaeure-oxim；2-(hydroxyimino)-3-(o-nitrophenyl)propionic acid；2-Nitrophenylpyruvic acid oxime；2-hydroxyimino-3-(2-nitrophenyl)propanoic acid
• CAS: 27878-36-0
• 化学式: C₉H₈N₂O₅
• 分子量: 224.173
• InChiKey: RSAXUEMHVKBRSZ-UHFFFAOYSA-N

物化性质

• 熔点：
  161 °C (decomp)
• 沸点：
  480.0±47.0 °C(Predicted)
• 密度：
  1.48±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  116
• 氢给体数：
  2
• 氢受体数：
  6

安全信息

• 海关编码：
  2928000090

反应信息

• 作为反应物：
  描述：

  2-(羟基亚胺)-3-(2-硝基苯基)丙酸 在 盐酸 、 乙醚 、 zinc(II) chloride 作用下， 生成 2,4-dihydroxy-2'-nitro-deoxybenzoin
  参考文献：
  名称：

  XXXIX：胶体酚盐。第二部分 一些菲黄酮

  摘要：

  DOI：

  10.1039/jr9300000261
• 作为产物：
  描述：

  <2-Nitro-phenyl>-glyoxylsaeure 在 sodium hydroxide 、 盐酸羟胺 作用下， 生成 2-(羟基亚胺)-3-(2-硝基苯基)丙酸
  参考文献：
  名称：

  Reissert, Chemische Berichte, 1908, vol. 41, p. 3812

  摘要：

  DOI：

文献信息

• 5-Diazacycloalkylimidazo[1,2-c][1,3]benzodiazepines
  申请人：Ciba-Geigy Corporation

  公开号：US04460508A1

  公开（公告）日：1984-07-17

  5-Diazacycloalkylimidazo[1,2-c][1,3]benzodiazepines, for example compounds of the formula ##STR1## in which e.g., R.sub.1, R.sub.2 and R.sub.4 are hydrogen, R.sub.3 is methyl and C.sub.n H.sub.2n is CH.sub.2 CH.sub.2, have neurcleptic and/or antihistaminic activity. The synthesis, pharmaceutical compositions and methods of treatment utilizing such compounds are described.

  5-二氮杂环戊基咪唑[1,2-c][1,3]苯并二氮平类化合物，例如式子##STR1##中，例如，R.sub.1，R.sub.2和R.sub.4为氢，R.sub.3为甲基，C.sub.n H.sub.2n为CH.sub.2 CH.sub.2，具有神经元抑制和/或抗组胺活性。描述了制备这种化合物的合成方法、制药组合物和治疗方法。
• Imidazo[1,2-c][1,3]benzodiazepines
  申请人：Ciba-Geigy Corporation

  公开号：US04459232A1

  公开（公告）日：1984-07-10

  5-Diazacycloalkylimidazo[1,2-c][1,3]benzodiazepines, for example compounds of the formula ##STR1## in which e.g., R.sub.1, R.sub.2 and R.sub.4 are hydrogen, R.sub.3 is methyl and C.sub.n H.sub.2n is CH.sub.2 CH.sub.2, have neuroleptic and/or antihistaminic activity. The synthesis, pharmaceutical compositions and methods of treatment utilizing such compounds are described.

  5-二氮杂环己基咪唑[1,2-c][1,3]苯二氮平类化合物，例如公式##STR1##中的化合物，其中例如，R.sub.1，R.sub.2和R.sub.4是氢，R.sub.3是甲基，C.sub.n H.sub.2n是CH.sub.2 CH.sub.2，具有神经抑制和/或抗组胺活性。本文描述了这些化合物的合成、制药组合物和治疗方法。
• 5-Diazacycloalkyl imidazo[1,2-c][1,3]benzodiazepines
  申请人：Ciba-Geigy Corporation

  公开号：US04460587A1

  公开（公告）日：1984-07-17

  5-Diazacycloalkylimidazo[1,2-c][1,3]benzodiazepines, for example compounds of the formula ##STR1## in which e.g., R.sub.1, R.sub.2 and R.sub.4 are hydrogen, R.sub.3 is methyl and C.sub.n H.sub.2n is CH.sub.2 CH.sub.2, have neuroleptic and/or antihistaminic activity. The synthesis, pharmaceutical compositions and methods of treatment utilizing such compounds are described.

  5-二氮杂环己基咪唑[1,2-c][1,3]苯二氮平类化合物，例如公式##STR1##中的化合物，其中例如R.sub.1、R.sub.2和R.sub.4为氢，R.sub.3为甲基，C.sub.n H.sub.2n为CH.sub.2 CH.sub.2，具有神经抑制和/或抗组胺活性。描述了制备、制药组合物和使用这些化合物的治疗方法。
• Neber; Huh, Justus Liebigs Annalen der Chemie, 1935, vol. 515, p. 283,288
  作者：Neber、Huh

  DOI：——

  日期：——
• New observations on spiculelike structures from Doushantuo phosphorites at Weng’an, Guizhou Province
  作者：Leiming Yin、Shuhai Xiao、Xunlai Yuan

  DOI：10.1007/bf02900561

  日期：2001.11

  Doushantuo phosphorites at Weng'an, Guizhou Province, provide a unique opportunity for the study of early evolution of multicellular organisms, including metazoans. Our light microscope and SEM observations, however, do not substantiate a sponge spicule interpretation of spicular structures. No convincing axial canals have been seen in the observed spicule population. Instead, the coexistence of some monaxonal spicules with clearly diagenetic crystal fascicles and dumbbells suggest that these monaxons may also be diagenetic in origin. Our preliminary EDS analyses detect no significant silicon in spicule-containing intraclasts (including abiotic clasts and fragments of sphaeromorphic acritarchs and algal thalli), that contain abundant monaxonal spicular structures. We, therefore, believe that the evidence for a sponge spicule interpretation of the Doushantuo spicular structures are at best ambiguous at present; these alleged sponge spicules are indistinguishable from coexistent diagenetic crystals.