2-(8-hydroxy-3,6-dioxaoctyl)thioxantheno[2,1,9-dej]isoqiunoline-1,3-dione | 650616-84-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 2-(8-hydroxy-3,6-dioxaoctyl)thioxantheno[2,1,9-dej]isoqiunoline-1,3-dione
• 英文别名: Benzothioxanthene-3,4-dicarboxylic acid-N-(5-hydroxypentyltimide)；14-(5-hydroxypentyl)-8-thia-14-azapentacyclo[10.6.2.02,7.09,19.016,20]icosa-1(19),2,4,6,9,11,16(20),17-octaene-13,15-dione
• CAS: 650616-84-5
• 化学式: C₂₃H₁₉NO₃S
• 分子量: 389.475
• InChiKey: IENXYAGGQJPELU-UHFFFAOYSA-N

物化性质

• 沸点：
  651.8±48.0 °C(Predicted)
• 密度：
  1.392±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  82.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(8-hydroxy-3,6-dioxaoctyl)thioxantheno[2,1,9-dej]isoqiunoline-1,3-dione 、 2-溴-2-甲基丙酰溴 在 三乙胺 作用下， 以 氯仿 为溶剂， 反应 18.0h， 以89%的产率得到2-(8-(2-bromodimethyl)-3,6-dioxa-octyl)-thioxantheno[2,1,9-dej]isoquinoline-1,3-dione
  参考文献：
  名称：

  Mucoadhesive and bioadhesive polymers

  摘要：

  这项发明提供了一种通过将一种局部组合物与屏障接触来增强上皮粘膜屏障的方法。这项发明还提供了该局部组合物。该局部组合物包括至少一种聚合物，该聚合物包含结构1的重复单元或结构2的重复单元，或二者的混合物，分散或溶解在局部可接受的载体中。该方法和组合物可用于通过将其局部应用于暴露或受伤的上皮表面，或通过在受损的粘膜屏障上涂覆，例如在炎症性肠病中，改善粘膜屏障功能。

  公开号：

  US20050281775A1
• 作为产物：
  描述：

  苯并噻吨二羧酸酐 、 5-氨基-1-戊醇 以 DMF (N,N-dimethyl-formamide) 、 水 为溶剂， 反应 3.0h， 生成 2-(8-hydroxy-3,6-dioxaoctyl)thioxantheno[2,1,9-dej]isoqiunoline-1,3-dione
  参考文献：
  名称：

  Functional fluorescent dyes

  摘要：

  以下是以以下公式表示的荧光功能染料：其中R1为氢或甲基；R2、R3、R4、R5和R6分别独立地选自氢、烷基、芳基、烷氧基、芳基烷基、烷基芳基、卤素和三氟甲基的基团；L是含有3到约15个碳原子的直链或支链烷基，该烷基基团可选择性地含有一个或多个链内杂原子。

  公开号：

  US20040016370A1

文献信息

• Functional fluorescent dyes
  申请人：3M Innovative Properties Company

  公开号：US20040016370A1

  公开（公告）日：2004-01-29

  Fluorescent functional dyes represented by the following formulas: 1 wherein R 1 is hydrogen or methyl; R 2 , R 3 , R 4 , R 5 , and R 6 are each independently selected from the group consisting of hydrogen, alkyl, aryl, alkoxy, aralkyl, alkaryl, halo, and trifluoromethyl; and L is a straight chain or branched chain alkylene containing 3 to about 15 carbon atoms, the alkylene group optionally containing one or more catenary heteroatoms.

  以下是以以下公式表示的荧光功能染料：其中R1为氢或甲基；R2、R3、R4、R5和R6分别独立地选自氢、烷基、芳基、烷氧基、芳基烷基、烷基芳基、卤素和三氟甲基的基团；L是含有3到约15个碳原子的直链或支链烷基，该烷基基团可选择性地含有一个或多个链内杂原子。
• COLORANT-POLYESTERS AND METHODS OF PRODUCING COLORANT-POLYESTERS
  申请人：FAUCHER Santiago

  公开号：US20120065359A1

  公开（公告）日：2012-03-15

  An enzymatic polymerization method of covalently linking a colorant to a polyester to produce a colorant-polyester compound, the method including the steps of: (a) providing a reaction solution comprised of an ester monomer, a colorant having or functionalized to have a hydroxyl group, and an enzymatic catalyst; (b) reacting the ester monomer and the colorant using the enzymatic catalyst to produce a polymeric product, wherein the polymeric product includes a colorant-polyester compound; and (c) separating the polymeric product from the reaction solution. A colorant-polyester compound includes a colorant covalently linked to a polyester and the polyester is obtained by polymerizing a lactone.
• TONER PARTICLES COMPRISING COLORANT-POLYESTERS
  申请人：FAUCHER Santiago

  公开号：US20120231386A1

  公开（公告）日：2012-09-13

  A toner composition including a colorant-polyester polymer having at least one colorant and at least one polyester resin, an optional non-colorant polyester polymer, an optional additional colorant, an optional wax, and an optional additive, where the colorant is covalently linked to some or all of the polyester resin and the polyester resin is obtained by polymerizing a lactone using an enzyme catalyst. Methods for preparing a toner composition including an emulsion aggregation process.
• US8652723B2
  申请人：——

  公开号：US8652723B2

  公开（公告）日：2014-02-18
• Mucoadhesive and bioadhesive polymers
  申请人：Carrington Dennis Stephen

  公开号：US20050281775A1

  公开（公告）日：2005-12-22

  This invention provides a method of augmenting an epithelial mucosal barrier, by contacting the barrier with a topical composition. This invention also provides the topical composition. The topical composition comprises, dispersed or dissolved in a topically acceptable vehicle, at least one polymer containing either a repeat unit of structure 1 or a repeat unit of structure 2, or a mixture This method and composition are useful in improving mucosal barrier function by, for example, topical application to an exposed or injured epithelial surface or by coating a compromised mucosal barrier in, for example, inflammatory bowel disease.

  这项发明提供了一种通过将一种局部组合物与屏障接触来增强上皮粘膜屏障的方法。这项发明还提供了该局部组合物。该局部组合物包括至少一种聚合物，该聚合物包含结构1的重复单元或结构2的重复单元，或二者的混合物，分散或溶解在局部可接受的载体中。该方法和组合物可用于通过将其局部应用于暴露或受伤的上皮表面，或通过在受损的粘膜屏障上涂覆，例如在炎症性肠病中，改善粘膜屏障功能。