1-Ethyl-1-butyl-hydrazin | 52728-56-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-Ethyl-1-butyl-hydrazin
• 英文别名: N-Ethyl-N-butyl-hydrazin；1-Butyl-1-ethylhydrazin；1-Butyl-1-ethylhydrazine
• CAS: 52728-56-0
• 化学式: C₆H₁₆N₂
• 分子量: 116.206
• InChiKey: GGVXCUYZOPPOAM-UHFFFAOYSA-N

物化性质

• 沸点：
  146-148 °C
• 密度：
  0.838±0.06 g/cm3(Predicted)
• 保留指数：
  862

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-Ethyl-1-butyl-hydrazin 、 2-(4-硝基苯基)乙酰氯 在 三乙胺 作用下， 以 乙醚 为溶剂， 生成 1-Ethyl-1-butyl-2-<4-nitro-phenyl>-acetyl-hydrazin
  参考文献：
  名称：

  The Resolution of 1-Ethyl-1-methyl-1-p-nitrobenzylamine-2-acetimide

  摘要：

  DOI：

  10.1021/jo01044a054
• 作为产物：
  描述：

  N-ethyl-N-butylamine hydrochloride 在 盐酸 、 lithium aluminium tetrahydride 、 sodium nitrite 作用下， 以 乙醚 为溶剂， 生成 1-Ethyl-1-butyl-hydrazin
  参考文献：
  名称：

  The Resolution of 1-Ethyl-1-methyl-1-p-nitrobenzylamine-2-acetimide

  摘要：

  DOI：

  10.1021/jo01044a054

文献信息

• [EN] SMALL MOLECULE FURIN INHIBITORS FOR TREATING INFECTIOUS DISEASES<br/>[FR] INHIBITEURS DE FURINE À PETITES MOLÉCULES POUR LE TRAITEMENT DE MALADIES INFECTIEUSES
  申请人：BP ASSET V INC

  公开号：WO2021097009A1

  公开（公告）日：2021-05-20

  Provided herein are methods of treating a viral infection in a subject in need thereof, comprising administering to the subject a compound of Formula (I), or a pharmaceutical composition comprising Formula (I). Further provided herein are methods for inhibiting the replication of a virus (e.g., a togaviridae family virus (e.g., an alphavirus (e.g., Chikungunya virus, Eastern equine encephalitis, Mayaro virus, Venezuelan equine encephalitis virus, Western equine encephalitis)), a filoviradae family virus (e.g., a Marburg virus (e.g., Marburg virus, Ravn virus)), human respiratory syncytial virus (i.e., human orthopneumo viru s ), a flavivirus (e.g., dengue virus, Usutu virus, Japanese encephalitis virus, Powassan virus, yellow fever), a paramyxoviridae family virus (e.g., an orthoparamyxovirinae virus (e.g., a henipavims (e.g., Nipah virus), a morbillivims (e.g., measles morbillivirus))) in a subject in need thereof. Also provided herein are methods for treating and/or preventing a disorder due to a microbial toxin (e.g., due to P. aeruginosa exotoxin A, Clostridium septicum alpha-toxin, diphtheria toxin(s), shiga toxin(s)) in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I), or a pharmaceutical composition comprising a compound of Formula (I) as described herein. Also provided are pharmaceutical compositions and kits including a compound of Formula (I) for use in the treatment and/or prevention of a viral infection in a subject in need thereof.

  本文提供了治疗需要的受试者体内病毒感染的方法，包括向受试者投与化合物I的方法，或者包含化合物I的药物组合物。本文还提供了用于抑制病毒复制的方法（例如togaviridae家族病毒（例如alphavirus（例如，基孔肯雅病毒，东部马脑炎，马雅罗病毒，委内瑞拉马脑炎病毒，西部马脑炎）），filoviradae家族病毒（例如马尔堡病毒（例如，马尔堡病毒，拉文病毒）），人类呼吸道合胞病毒（即人类正交病毒），黄病毒（例如登革病毒，乌苏图病毒，日本脑炎病毒，波瓦松病毒，黄热病），paramyxoviridae家族病毒（例如正参数病毒（例如蝙蝠病毒（例如，尼帕病毒），麻病毒（例如，麻疹麻病毒）））的方法。本文还提供了治疗和/或预防由微生物毒素引起的紊乱的方法（例如由P. aeruginosa外毒素A，肠炎类固醇α-毒素，白喉毒素，志贺毒素引起的紊乱）的方法，包括向受试者投与化合物I的治疗有效量，或者包含本文所述的化合物I的药物组合物。还提供了包含化合物I的药物组合物和配套用品，用于治疗和/或预防需要的受试者体内的病毒感染。
• Expandable and curable polyester composition and method for making same
  申请人：UNIROYAL, INC.

  公开号：EP0083173A1

  公开（公告）日：1983-07-06

  An expandable and curable polyester composition comprising a mixture of a liquid, ethylenically unsaturated polyester resin composition; a peroxide; an organometallic promotor; and a dialkyl or trialkyl hydrazine is disclosed. In addition, a method for forming said expanded and cured polyester resin composition, and the product formed in accordance with said method, an expanded and cured polyester resin composition, is taught.

  本发明公开了一种可膨胀固化的聚酯组合物，该组合物包含一种液态乙烯基不饱和聚酯树脂组合物、一种过氧化物、一种有机金属促进剂和一种二烷基或三烷基肼的混合物。 此外，还教导了一种形成所述膨胀固化聚酯树脂组合物的方法，以及根据所述方法形成的产品--膨胀固化聚酯树脂组合物。
• A process for isolating coagulation factors, and adsorbent material suitable therefor
  申请人：UNIVERSITEIT TWENTE

  公开号：EP0303329A1

  公开（公告）日：1989-02-15

  This invention relates to a process and to adsorbent material for isolating coagulation factors, including FVIII and vWF, from for example blood plasma and plasma products by means of liquid chromatography. The adsorbent material comprises a polymeric carrier to which amino groups are linked as ligands through spacers. The spacers have a chain length of at least 6 atoms and contain at least one hydrophilic link within the chain. The spacers preferably have the formula -(CH₂)m-CO-NH-(CH₂)n- ­wherein m and n each represent an integer of 1-6 and m+n is at least 4. The spacers are preferably linked to the carrier through -CO-NH- groups. The ligand density in the adsorbent material is preferably higher than 30 umoles/ml of swollen matrix.

  本发明涉及一种通过液相色谱法从血浆和血浆制品等中分离凝血因子（包括 FVIII 和 vWF）的工艺和吸附材料。吸附材料包括一种聚合物载体，其上通过间隔物连接有作为配体的氨基。间隔物的链长至少为 6 个原子，链中至少含有一个亲水链节。间隔物最好具有式-(CH₂)m-CO-NH-(CH₂)n-，其中 m 和 n 分别代表 1-6 的整数，m+n 至少为 4。 间隔物最好通过-CO-NH-基团与载体相连。吸附材料中的配体密度最好高于 30 微摩尔/毫升膨胀基质。
• LATENT CURING AGENTS, EPOXY RESIN COMPOSITIONS CONATING THE SAME, SEALING MATERIALS, AND ORGANIC EL DISPLAYS
  申请人：Mitsui Chemicals, Inc.

  公开号：EP2199313A1

  公开（公告）日：2010-06-23

  The invention aims to provide latent curing agents which exert high low-temperature curing properties when used together with ionically polymerizable compounds and which exhibit high storage stability at room temperature. Latent curing agents for ionically polymerizable compounds which agents each contain a hydroxyl-free amine imide compound having an N-N bond energy of 100 to 210 kJ/mol as determined by B3LYP functional theory method.

  本发明旨在提供与离子可聚合化合物一起使用时具有较高低温固化性能，并且在室温下具有较高储存稳定性的潜在固化剂。用于离子可聚合化合物的潜在固化剂，每种固化剂都含有一种无羟基胺亚胺化合物，根据 B3LYP 功能理论方法测定，其 N-N 键能量为 100 至 210 kJ/mol。
• GYPSUM DISPERSANT
  申请人：Toho Chemical Industry Co., Ltd.

  公开号：EP2826760A1

  公开（公告）日：2015-01-21

  There is provided a gypsum dispersant and a gypsum additive that improve the fluidity of gypsum slurry even if gypsum raw materials used are different in quality and that do not induce delay of curing of gypsum slurry. A gypsum dispersant, characterized by comprising: (A) a polycarboxylic acid polymer; and (B) a polymer obtained by a reaction of an alkylene diamine and/or a monoamine and an epihalohydrin as essential components.

  提供了一种石膏分散剂和石膏添加剂，即使使用的石膏原料质量不同，也能改善石膏浆液的流动性，并且不会导致石膏浆液固化延迟。一种石膏分散剂，其特征在于包括：(A)聚羧酸聚合物；和(B)由亚烷基二胺和/或单胺与表卤素反应而得的聚合物，作为基本成分。